Genome-wide significant associations with the C allele in rs11980379 (IKZF1) and B-ALL by sex in EAs
| Sex . | N cases (Cohort 1/Cohort 2) . | Cohort 1 . | Cohort 2 . | ORmeta (95% CI) . | Pmeta . | I2 (P) . | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |||||
| Male | 219/53 | 1.9 (1.4, 2.3) | 1.5 × 10−7 | 1.5 (0.9, 2.2) | .05 | 1.8 (1.2, 2.5) | 3.8 × 10−8 | 80.2 (.02) |
| Female | 145/29 | 1.2 (0.9, 1.6) | .13 | 1.4 (0.6, 2.1) | .3 | 1.3 (0.9, 1.7) | .06 | |
| Sex . | N cases (Cohort 1/Cohort 2) . | Cohort 1 . | Cohort 2 . | ORmeta (95% CI) . | Pmeta . | I2 (P) . | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |||||
| Male | 219/53 | 1.9 (1.4, 2.3) | 1.5 × 10−7 | 1.5 (0.9, 2.2) | .05 | 1.8 (1.2, 2.5) | 3.8 × 10−8 | 80.2 (.02) |
| Female | 145/29 | 1.2 (0.9, 1.6) | .13 | 1.4 (0.6, 2.1) | .3 | 1.3 (0.9, 1.7) | .06 | |
I2 and P reflect heterogeneity in the SNP associations with B-ALL between males and females.
OR, odds ratio of logistic additive model risk is presented in terms of the C (minor) allele.