Effect of donor racial background on osmotic, oxidative, or storage hemolysis
| Hemolysis (%) . | Mean ± SD . | Range . | P . | Percentiles . | No. of donors . | ||||
|---|---|---|---|---|---|---|---|---|---|
| 5 . | 25 . | 50 . | 75 . | 95 . | |||||
| Osmotic | |||||||||
| White | 30.6 ± 12.7 | 1.3-93.4 | 11.4 | 21.3 | 29.4 | 39.0 | 53.3 | 6059 | |
| African American | 17.9 ± 10.6 | 0.0-65.1 | <.0001 | 3.9 | 9.7 | 16.2 | 24.4 | 37.7 | 1497 |
| Asian | 28.1 ± 13.3 | 0.1-74.5 | <.0001 | 8.6 | 17.9 | 26.5 | 37.0 | 51.4 | 1498 |
| Hispanic | 29.3 ± 12.6 | 1.1-73.7 | .005 | 10.5 | 19.9 | 28.7 | 37.8 | 51.0 | 966 |
| Other | 27.4 ± 13.6 | 1.9-69.9 | <.0001 | 7.3 | 16.9 | 26.2 | 36.2 | 51.7 | 572 |
| Oxidative | |||||||||
| White | 36.7 ± 9.6 | 6.0-74.3 | 20.8 | 30.5 | 36.8 | 42.9 | 52.7 | 4663 | |
| African American | 37.7 ± 10.7 | 3.9-77.1 | .0028 | 18.6 | 31.0 | 38.1 | 44.6 | 54.3 | 1387 |
| Asian | 38.4 ± 9.8 | 4.1-67.6 | <.0001 | 21.4 | 31.9 | 39.2 | 45.3 | 54.0 | 1178 |
| Hispanic | 39.0 ± 9.6 | 5.9-70.0 | <.0001 | 22.5 | 33.3 | 39.5 | 45.3 | 53.5 | 837 |
| Other | 38.5 ± 10.3 | 5.6-68.2 | .0005 | 20.3 | 31.8 | 38.9 | 45.7 | 53.9 | 437 |
| Storage | |||||||||
| White | 0.36 ± 0.21 | 0.00-3.63 | 0.17 | 0.24 | 0.31 | 0.41 | 0.70 | 6031 | |
| African American | 0.38 ± 0.23 | 0.09-3.19 | .0028 | 0.17 | 0.25 | 0.32 | 0.42 | 0.80 | 1497 |
| Asian | 0.43 ± 0.44 | 0.05-10.5 | <.0001 | 0.17 | 0.25 | 0.34 | 0.47 | 0.91 | 1491 |
| Hispanic | 0.41 ± 0.58 | 0.06-16.2 | .0189 | 0.18 | 0.25 | 0.32 | 0.45 | 0.75 | 963 |
| Other | 0.36 ± 0.27 | 0.09-3.74 | .9735 | 0.16 | 0.23 | 0.31 | 0.41 | 0.70 | 570 |
| Hemolysis (%) . | Mean ± SD . | Range . | P . | Percentiles . | No. of donors . | ||||
|---|---|---|---|---|---|---|---|---|---|
| 5 . | 25 . | 50 . | 75 . | 95 . | |||||
| Osmotic | |||||||||
| White | 30.6 ± 12.7 | 1.3-93.4 | 11.4 | 21.3 | 29.4 | 39.0 | 53.3 | 6059 | |
| African American | 17.9 ± 10.6 | 0.0-65.1 | <.0001 | 3.9 | 9.7 | 16.2 | 24.4 | 37.7 | 1497 |
| Asian | 28.1 ± 13.3 | 0.1-74.5 | <.0001 | 8.6 | 17.9 | 26.5 | 37.0 | 51.4 | 1498 |
| Hispanic | 29.3 ± 12.6 | 1.1-73.7 | .005 | 10.5 | 19.9 | 28.7 | 37.8 | 51.0 | 966 |
| Other | 27.4 ± 13.6 | 1.9-69.9 | <.0001 | 7.3 | 16.9 | 26.2 | 36.2 | 51.7 | 572 |
| Oxidative | |||||||||
| White | 36.7 ± 9.6 | 6.0-74.3 | 20.8 | 30.5 | 36.8 | 42.9 | 52.7 | 4663 | |
| African American | 37.7 ± 10.7 | 3.9-77.1 | .0028 | 18.6 | 31.0 | 38.1 | 44.6 | 54.3 | 1387 |
| Asian | 38.4 ± 9.8 | 4.1-67.6 | <.0001 | 21.4 | 31.9 | 39.2 | 45.3 | 54.0 | 1178 |
| Hispanic | 39.0 ± 9.6 | 5.9-70.0 | <.0001 | 22.5 | 33.3 | 39.5 | 45.3 | 53.5 | 837 |
| Other | 38.5 ± 10.3 | 5.6-68.2 | .0005 | 20.3 | 31.8 | 38.9 | 45.7 | 53.9 | 437 |
| Storage | |||||||||
| White | 0.36 ± 0.21 | 0.00-3.63 | 0.17 | 0.24 | 0.31 | 0.41 | 0.70 | 6031 | |
| African American | 0.38 ± 0.23 | 0.09-3.19 | .0028 | 0.17 | 0.25 | 0.32 | 0.42 | 0.80 | 1497 |
| Asian | 0.43 ± 0.44 | 0.05-10.5 | <.0001 | 0.17 | 0.25 | 0.34 | 0.47 | 0.91 | 1491 |
| Hispanic | 0.41 ± 0.58 | 0.06-16.2 | .0189 | 0.18 | 0.25 | 0.32 | 0.45 | 0.75 | 963 |
| Other | 0.36 ± 0.27 | 0.09-3.74 | .9735 | 0.16 | 0.23 | 0.31 | 0.41 | 0.70 | 570 |
P values were obtained by t tests, which compared the mean hemolysis value of each minority group with that of white donors. Because of multiple testing, differences were considered significant at P < .001.