Clone sizes, clonality patterns, and clinical progression among patients with adult T-cell leukemia
| Patients . | Time point 1 . | Clonality pattern . | Time point 2 . | Clonality pattern . | Clinical progression . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Top . | Second . | Sum . | Top . | Second . | Sum . | ||||
| P10 | 2287 | 120 | 2407 | Monoclonal | 1857 | 71 | 1928 | Monoclonal | − |
| P11 | 1904 | 1690 | 3594 | Oligoclonal | 2742 | 2055 | 4797 | Oligoclonal | − |
| P12 | 1446 | 1088 | 2534 | Oligoclonal | 2824 | 2318 | 5142 | Oligoclonal | − |
| P13 | 2851 | 456 | 3307 | Monoclonal | 2567 | 193 | 2760 | Monoclonal | − |
| P14 | 3343 | 6 | 3349 | Monoclonal | 3882 | 6 | 3888 | Monoclonal | +* |
| P15 | 1455 | 1407 | 2862 | Oligoclonal | 2029 | 361 | 2390 | Monoclonal | + |
| P16 | 3727 | 12 | 3739 | Monoclonal | 3735 | 2 | 3737 | Monoclonal | +* |
| P17 | 4033 | 22 | 4055 | Monoclonal | 4187 | 16 | 4203 | Monoclonal | − |
| P18 | 3457 | 649 | 4106 | Oligoclonal | 3246 | 797 | 4043 | Oligoclonal | − |
| P19 | 3700 | 3560 | 7260 | Oligoclonal | 3293 | 3226 | 6519 | Oligoclonal | − |
| P20 | 5377 | 14 | 5391 | Monoclonal | 4909 | 17 | 4926 | Monoclonal | +* |
| Patients . | Time point 1 . | Clonality pattern . | Time point 2 . | Clonality pattern . | Clinical progression . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Top . | Second . | Sum . | Top . | Second . | Sum . | ||||
| P10 | 2287 | 120 | 2407 | Monoclonal | 1857 | 71 | 1928 | Monoclonal | − |
| P11 | 1904 | 1690 | 3594 | Oligoclonal | 2742 | 2055 | 4797 | Oligoclonal | − |
| P12 | 1446 | 1088 | 2534 | Oligoclonal | 2824 | 2318 | 5142 | Oligoclonal | − |
| P13 | 2851 | 456 | 3307 | Monoclonal | 2567 | 193 | 2760 | Monoclonal | − |
| P14 | 3343 | 6 | 3349 | Monoclonal | 3882 | 6 | 3888 | Monoclonal | +* |
| P15 | 1455 | 1407 | 2862 | Oligoclonal | 2029 | 361 | 2390 | Monoclonal | + |
| P16 | 3727 | 12 | 3739 | Monoclonal | 3735 | 2 | 3737 | Monoclonal | +* |
| P17 | 4033 | 22 | 4055 | Monoclonal | 4187 | 16 | 4203 | Monoclonal | − |
| P18 | 3457 | 649 | 4106 | Oligoclonal | 3246 | 797 | 4043 | Oligoclonal | − |
| P19 | 3700 | 3560 | 7260 | Oligoclonal | 3293 | 3226 | 6519 | Oligoclonal | − |
| P20 | 5377 | 14 | 5391 | Monoclonal | 4909 | 17 | 4926 | Monoclonal | +* |
−, Maintained clinical status; +, progressed to advanced subtype; second, second-largest clone; sum, sum of top and second clone sizes; top, largest clone.
Progressed to aggressive subtype.