Comparison of laboratory variables by genetic variants in patients with SCA from the University of Ibadan
| α-Thalassemia . | |||||
|---|---|---|---|---|---|
| . | N . | αα/αα . | N . | α-/αα or α-/α- . | P . |
| WBC count, × 103/µL | 143 | 12.5 (10.2-15.4) | 106 | 10.8 (9.0-14.6) | .024 |
| Hemoglobin, g/dL | 143 | 7.7 (6.9-8.5) | 106 | 7.5 (6.6-8.6) | .5 |
| Reticulocyte, % | 40 | 10.5 (3.5-17.1) | 32 | 7.9 (3.3-12.7) | .4 |
| VOCs ≥3/y, n (%) | 143 | 124 (87) | 106 | 82 (77) | .1 |
| Stroke history, n (%) | 143 | 6 (4) | 106 | 1 (1) | .1 |
| α-Thalassemia . | |||||
|---|---|---|---|---|---|
| . | N . | αα/αα . | N . | α-/αα or α-/α- . | P . |
| WBC count, × 103/µL | 143 | 12.5 (10.2-15.4) | 106 | 10.8 (9.0-14.6) | .024 |
| Hemoglobin, g/dL | 143 | 7.7 (6.9-8.5) | 106 | 7.5 (6.6-8.6) | .5 |
| Reticulocyte, % | 40 | 10.5 (3.5-17.1) | 32 | 7.9 (3.3-12.7) | .4 |
| VOCs ≥3/y, n (%) | 143 | 124 (87) | 106 | 82 (77) | .1 |
| Stroke history, n (%) | 143 | 6 (4) | 106 | 1 (1) | .1 |
| BCL11A rs1427407 . | |||||
|---|---|---|---|---|---|
| . | N . | G/G . | N . | G/T or T/T . | P . |
| WBC count, × 103/µL | 133 | 11.4 (9.6-14.7) | 116 | 12.0 (9.8-15.4) | .7 |
| Hemoglobin, g/dL | 133 | 7.5 (6.6-8.3) | 116 | 7.8 (6.9-8.6) | .074 |
| Reticulocyte, % | 32 | 12.3 (3.5-18.2) | 40 | 7.6 (3.4-11.8) | .2 |
| VOCs ≥3/y, n (%) | 133 | 115 (86) | 116 | 93 (80) | .2 |
| Stroke history, n (%) | 133 | 5 (4) | 116 | 2 (2) | .3 |
| BCL11A rs1427407 . | |||||
|---|---|---|---|---|---|
| . | N . | G/G . | N . | G/T or T/T . | P . |
| WBC count, × 103/µL | 133 | 11.4 (9.6-14.7) | 116 | 12.0 (9.8-15.4) | .7 |
| Hemoglobin, g/dL | 133 | 7.5 (6.6-8.3) | 116 | 7.8 (6.9-8.6) | .074 |
| Reticulocyte, % | 32 | 12.3 (3.5-18.2) | 40 | 7.6 (3.4-11.8) | .2 |
| VOCs ≥3/y, n (%) | 133 | 115 (86) | 116 | 93 (80) | .2 |
| Stroke history, n (%) | 133 | 5 (4) | 116 | 2 (2) | .3 |
| Genetic risk profile . | |||||
|---|---|---|---|---|---|
| . | N . | High risk . | N . | Standard risk . | P . |
| WBC count, × 103/µL | 78 | 12.2 (10.2-15.1) | 171 | 11.4 (9.5-14.9) | .3 |
| Hemoglobin, g/dL | 78 | 7.6 (6.8-8.3) | 171 | 7.7 (6.7-8.6) | .6 |
| Reticulocyte, % | 15 | 15.0 (5.1-20.2) | 57 | 7.8 (3.0-12.9) | .076 |
| VOCs ≥ 3/y, n (%) | 78 | 70 (90) | 171 | 136 (80) | .069 |
| Stroke history, n (%) | 78 | 5 (6) | 171 | 2 (1) | .020 |
| Genetic risk profile . | |||||
|---|---|---|---|---|---|
| . | N . | High risk . | N . | Standard risk . | P . |
| WBC count, × 103/µL | 78 | 12.2 (10.2-15.1) | 171 | 11.4 (9.5-14.9) | .3 |
| Hemoglobin, g/dL | 78 | 7.6 (6.8-8.3) | 171 | 7.7 (6.7-8.6) | .6 |
| Reticulocyte, % | 15 | 15.0 (5.1-20.2) | 57 | 7.8 (3.0-12.9) | .076 |
| VOCs ≥ 3/y, n (%) | 78 | 70 (90) | 171 | 136 (80) | .069 |
| Stroke history, n (%) | 78 | 5 (6) | 171 | 2 (1) | .020 |
Values are expressed as medians and IQRs.