Prognostic significance of FISH-detected genetic changes in myeloma.
| Study . | No. patients . | Therapy . | Genomic abnormality/FISH probe . | Frequency, % . | Median overall survival, mo . |
|---|---|---|---|---|---|
| Abbreviations: NR, not reached. | |||||
| Zojer et al21 | 104 | Conventional chemotherapy | 13q34/Rb-1, D13S319 | 46 | 24 vs > 60 (P = .008) |
| Shaughnessy et al22 | 231 | High-dose therapy x 2 | 13q34 | 51 | Significantly shorter in del 13 |
| Fonseca et al15 | 325 | Conventional chemotherapy | 13q34/Rb-1, D13S319 | 54 | 34.9 vs 51 (P = .021) |
| Chiecchio et al23 | 729 | Conventional chemotherapy | t(4;14) | 12 | 19 vs 44 (P = .002) |
| t(11;14) | 15 | NR vs 36 (P = .29) | |||
| Δ13 | 48 | 29 vs 47 (P < .001) | |||
| 17p13 | 9 | 19 vs 43 (P < .001) | |||
| Facon et al24 | 110 | High-dose therapy | Δ13/D13S319 | 38 | 27 vs 65 (P < .0001) |
| Chang et al25 | 105 | High-dose therapy | Del 17p13/p53 | 10 | 15 vs 48 (P < .0008) |
| Drach et al26 | 72 | Conventional chemotherapy | Del 17p13/p53 | 33 newly diagnosed 55 relapsed | 13.9 vs 39.7 (P < .0001) |
| Keats et al27 | 208 | Conventional chemotherapy | t(4;14) | 15 | 21 vs 43 (P = .006) |
| Study . | No. patients . | Therapy . | Genomic abnormality/FISH probe . | Frequency, % . | Median overall survival, mo . |
|---|---|---|---|---|---|
| Abbreviations: NR, not reached. | |||||
| Zojer et al21 | 104 | Conventional chemotherapy | 13q34/Rb-1, D13S319 | 46 | 24 vs > 60 (P = .008) |
| Shaughnessy et al22 | 231 | High-dose therapy x 2 | 13q34 | 51 | Significantly shorter in del 13 |
| Fonseca et al15 | 325 | Conventional chemotherapy | 13q34/Rb-1, D13S319 | 54 | 34.9 vs 51 (P = .021) |
| Chiecchio et al23 | 729 | Conventional chemotherapy | t(4;14) | 12 | 19 vs 44 (P = .002) |
| t(11;14) | 15 | NR vs 36 (P = .29) | |||
| Δ13 | 48 | 29 vs 47 (P < .001) | |||
| 17p13 | 9 | 19 vs 43 (P < .001) | |||
| Facon et al24 | 110 | High-dose therapy | Δ13/D13S319 | 38 | 27 vs 65 (P < .0001) |
| Chang et al25 | 105 | High-dose therapy | Del 17p13/p53 | 10 | 15 vs 48 (P < .0008) |
| Drach et al26 | 72 | Conventional chemotherapy | Del 17p13/p53 | 33 newly diagnosed 55 relapsed | 13.9 vs 39.7 (P < .0001) |
| Keats et al27 | 208 | Conventional chemotherapy | t(4;14) | 15 | 21 vs 43 (P = .006) |