Table 3. Impact of molecular markers on... | American Society of Hematology

Table 3.

Impact of molecular markers on prognosis in chronic lymphocytic leukemia (CLL).

Marker		Frequency, %	TTT, mo	OS, mo	Reference
* Hamblin et al 1999,⁸ 2002²⁷
Abbreviations: TTT, time to treatment; OS, overall survival
Cytogenetics	del 13p	55	92	133	Dohner et al 2000³
	Normal	18	49	111
	Trisomy 12	16	33	114
	del 11q	13	13	—
	del 17p	9	9	—
IgVH	Mutated	47	110	300*	Rassenti et al 2004²²
	Unmutated	53	42	115*	Hamblin et al 1999⁸
ZAP70	Negative	54	110	NS	Rassenti et al 2004²²
	Positive	46	35	NS
CD38	Negative	67	94	193*	Rassenti et al 2008³⁷
	Positive	33	40	109*	Hamblin et al 2002²⁷

Marker		Frequency, %	TTT, mo	OS, mo	Reference
* Hamblin et al 1999,⁸ 2002²⁷
Abbreviations: TTT, time to treatment; OS, overall survival
Cytogenetics	del 13p	55	92	133	Dohner et al 2000³
	Normal	18	49	111
	Trisomy 12	16	33	114
	del 11q	13	13	—
	del 17p	9	9	—
IgVH	Mutated	47	110	300*	Rassenti et al 2004²²
	Unmutated	53	42	115*	Hamblin et al 1999⁸
ZAP70	Negative	54	110	NS	Rassenti et al 2004²²
	Positive	46	35	NS
CD38	Negative	67	94	193*	Rassenti et al 2008³⁷
	Positive	33	40	109*	Hamblin et al 2002²⁷