Table 1.

Epidemiologic study designs to evaluate the risk of late effects.

Cohort study: well-defined group of patients followed for late effects 
Sources of cohort studies include:
  • Population-based cancer registries

  • Clinical trial databases

  • Hospital-based cancer registries

 
Case control study: treatment is compared between patients with and without the late effect of interest 
Cohort study: well-defined group of patients followed for late effects 
Sources of cohort studies include:
  • Population-based cancer registries

  • Clinical trial databases

  • Hospital-based cancer registries

 
Case control study: treatment is compared between patients with and without the late effect of interest 
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