Risk of pregnancy complications in women with inherited thrombophilias.
| Thrombophilia . | Early (recurrent) loss, OR (95% CI) . | Late loss, OR (95% CI) . | Pre-eclampsia, OR (95% CI) . | Placental abruption, OR (95% CI) . | IUGR, OR (95% CI) . |
|---|---|---|---|---|---|
| Data from Robertson et al.36 | |||||
| Abbreviations: IUGR, intrauterine growth restriction; OR, odds ratio; CI, confidence interval | |||||
| Factor V Leiden (homozygous) | 2.71 (1.32–5.58) | 1.98 (0.40–9.69) | 1.87 (0.44–7.88) | 8.43 (0.41–171.20) | 4.64 (0.19–115.68) |
| Factor V Leiden (heterozygous) | 1.68 (1.09–2.58) | 2.06 (1.10–3.86) | 2.19 (1.46–3.27) | 4.70 (1.13–19.59) | 2.68 (0.59–12.13) |
| Prothrombin gene variant (heterozygous) | 2.49 (1.24–5.00) | 2.66 (1.28–5.53) | 2.54 (1.52–4.23) | 7.71 (3.01–19.76) | 2.92 (0.62–13.70) |
| MTHFR C677T (homozygous) | 1.40 (0.77–2.55) | 1.31 (0.89–1.91) | 1.37 (1.07–1.76) | 1.47 (0.40–5.35) | 1.24 (0.84–1.82) |
| Antithrombin deficiency | 0.88 (0.17–4.48) | 7.63 (0.30–196.36) | 3.89 (0.16–97.19) | 1.08 (0.06–18.12) | NA |
| Protein C deficiency | 2.29 (0.20–26.43) | 3.05 (0.24–38.51) | 5.15 (0.26–102.22) | 5.93 (0.23–151.58) | NA |
| Protein S deficiency | 3.55 (0.35–35.72) | 20.09 (3.70–109.15) | 2.83 (0.76–10.57) | 2.11 (0.47–9.34) | NA |
| Thrombophilia . | Early (recurrent) loss, OR (95% CI) . | Late loss, OR (95% CI) . | Pre-eclampsia, OR (95% CI) . | Placental abruption, OR (95% CI) . | IUGR, OR (95% CI) . |
|---|---|---|---|---|---|
| Data from Robertson et al.36 | |||||
| Abbreviations: IUGR, intrauterine growth restriction; OR, odds ratio; CI, confidence interval | |||||
| Factor V Leiden (homozygous) | 2.71 (1.32–5.58) | 1.98 (0.40–9.69) | 1.87 (0.44–7.88) | 8.43 (0.41–171.20) | 4.64 (0.19–115.68) |
| Factor V Leiden (heterozygous) | 1.68 (1.09–2.58) | 2.06 (1.10–3.86) | 2.19 (1.46–3.27) | 4.70 (1.13–19.59) | 2.68 (0.59–12.13) |
| Prothrombin gene variant (heterozygous) | 2.49 (1.24–5.00) | 2.66 (1.28–5.53) | 2.54 (1.52–4.23) | 7.71 (3.01–19.76) | 2.92 (0.62–13.70) |
| MTHFR C677T (homozygous) | 1.40 (0.77–2.55) | 1.31 (0.89–1.91) | 1.37 (1.07–1.76) | 1.47 (0.40–5.35) | 1.24 (0.84–1.82) |
| Antithrombin deficiency | 0.88 (0.17–4.48) | 7.63 (0.30–196.36) | 3.89 (0.16–97.19) | 1.08 (0.06–18.12) | NA |
| Protein C deficiency | 2.29 (0.20–26.43) | 3.05 (0.24–38.51) | 5.15 (0.26–102.22) | 5.93 (0.23–151.58) | NA |
| Protein S deficiency | 3.55 (0.35–35.72) | 20.09 (3.70–109.15) | 2.83 (0.76–10.57) | 2.11 (0.47–9.34) | NA |