Hematologic data in various hemoglobin E syndromes10 (modified).
| . | Hb, g/dL . | MCV, fL . | MCH, pg . | MCHC, g/dL . | RDW, % . | Alkali denaturation test (Hb F),% . | Hb typing . |
|---|---|---|---|---|---|---|---|
| Abbreviations: CS, Hb Constant Spring; D, decreased; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; N, normal; ND, not determined; RDW, red cell distribution width | |||||||
| Normal | M15.9 ± 0.9 F12.5 ± 2.0 | 87 ± 6 | 31 ± 1.1 | 33 ± 0.9 | 13.1 ± 0.8 | 0.5 ± 0.2 | A2 (2.5 ± 0.2) + A |
| Hb E trait | 12.8 ± 1.5 | 84 ± 5 | 30 ± 2.4 | 33 ± 1.8 | 14.1 ± 0.6 | 0.9 ± 0.7 | E (29.4 ± 2.3%) + A |
| Hb E α-thalassemia 2 | 13.1 ± 1.4 | 88 ± 4 | ND | ND | ND | E (28.5 ± 1.5%) + A | |
| Hb E α-thalassemia 1 | 12.5 ± 1.4 | 77 ± 5 | 23 ± 1.1 | 32 ± 1.6 | ND | 0.9 ± 0.4 | E (20.7 ± 1.2%) + A |
| Homozygous HbE | 11.4 ± 1.8 | 70 ± 4 | 22 ± 1.9 | 33 ± 1.7 | 15.6 | 1.8 ± 1.4 | E (87.7 ± 5.9%) |
| Hb E/β0-thalassemia | 7.8 ± 2.6 | 67 ± 6 | 19 ± 3.6 | 28 ± 4.8 | 26.5 ± 5.6 | 42 ± 1.5 | E (58 ± 1.5%) + F |
| AE Bart’s disease | E (13.0 ± 2.1%) + A + Bart’s (2.2 ± 1.8%) | ||||||
| α-thalassemia 1/α-thalassemia 2-Hb E | 9.1 ± 1.1 | 60 ± 3 | 17 ± 2 | 31 ± 4 | ND | 2.0 ± 0.7 | |
| α-thalassemia 1/Hb CS-Hb E | 8.0 ± 0.9 | 67 ± 4 | 19 ± 2 | 29 ± 2 | ND | 2.3 ± 1.4 | CS (1.1 ± 0.4%) + E (13.9 ± 1.8%) + A + Bart’s (3.9 ± 1.5%) |
| Hb EE + Hb H | 8.0 ± 1.3 | 63 ± 6 | 18 ± 2 | 29 ± 2 | ND | 5.8 ± 3.7 | E (80%) + F + Bart’s(5%) or CS (1.9 ± 0.9%) + E (86.4 ± 8%) + F + Bart’s (3.7 ± 1.9%) |
| Hb SE12 | 11.2 ± 1.8 | 75 ± 10 | ND | ND | ND | ND | Hb S (62.8% ± 7.4%), Hb E (33.3% ± 3.6%), Hb F (range 1 – 5.2) |
| . | Hb, g/dL . | MCV, fL . | MCH, pg . | MCHC, g/dL . | RDW, % . | Alkali denaturation test (Hb F),% . | Hb typing . |
|---|---|---|---|---|---|---|---|
| Abbreviations: CS, Hb Constant Spring; D, decreased; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; N, normal; ND, not determined; RDW, red cell distribution width | |||||||
| Normal | M15.9 ± 0.9 F12.5 ± 2.0 | 87 ± 6 | 31 ± 1.1 | 33 ± 0.9 | 13.1 ± 0.8 | 0.5 ± 0.2 | A2 (2.5 ± 0.2) + A |
| Hb E trait | 12.8 ± 1.5 | 84 ± 5 | 30 ± 2.4 | 33 ± 1.8 | 14.1 ± 0.6 | 0.9 ± 0.7 | E (29.4 ± 2.3%) + A |
| Hb E α-thalassemia 2 | 13.1 ± 1.4 | 88 ± 4 | ND | ND | ND | E (28.5 ± 1.5%) + A | |
| Hb E α-thalassemia 1 | 12.5 ± 1.4 | 77 ± 5 | 23 ± 1.1 | 32 ± 1.6 | ND | 0.9 ± 0.4 | E (20.7 ± 1.2%) + A |
| Homozygous HbE | 11.4 ± 1.8 | 70 ± 4 | 22 ± 1.9 | 33 ± 1.7 | 15.6 | 1.8 ± 1.4 | E (87.7 ± 5.9%) |
| Hb E/β0-thalassemia | 7.8 ± 2.6 | 67 ± 6 | 19 ± 3.6 | 28 ± 4.8 | 26.5 ± 5.6 | 42 ± 1.5 | E (58 ± 1.5%) + F |
| AE Bart’s disease | E (13.0 ± 2.1%) + A + Bart’s (2.2 ± 1.8%) | ||||||
| α-thalassemia 1/α-thalassemia 2-Hb E | 9.1 ± 1.1 | 60 ± 3 | 17 ± 2 | 31 ± 4 | ND | 2.0 ± 0.7 | |
| α-thalassemia 1/Hb CS-Hb E | 8.0 ± 0.9 | 67 ± 4 | 19 ± 2 | 29 ± 2 | ND | 2.3 ± 1.4 | CS (1.1 ± 0.4%) + E (13.9 ± 1.8%) + A + Bart’s (3.9 ± 1.5%) |
| Hb EE + Hb H | 8.0 ± 1.3 | 63 ± 6 | 18 ± 2 | 29 ± 2 | ND | 5.8 ± 3.7 | E (80%) + F + Bart’s(5%) or CS (1.9 ± 0.9%) + E (86.4 ± 8%) + F + Bart’s (3.7 ± 1.9%) |
| Hb SE12 | 11.2 ± 1.8 | 75 ± 10 | ND | ND | ND | ND | Hb S (62.8% ± 7.4%), Hb E (33.3% ± 3.6%), Hb F (range 1 – 5.2) |