Table 3.

Prospective randomized and nonrandomized trials of all-trans retinoic acid (ATRA) and chemotherapy in acute promyelocytic leukemia (APL).43 

TrialNInduction% CR% ED% ED due to hemorrhage% DFS/EFS
Abbreviations: CR, complete remission; ED, early death; DFS, disease-free survival; EFS, event-free survival 
APL91 (Europe)35  54 ATRA + Chemo 97 9 60 79 
 47 Chemo 81 8 75 50 
APL93 (Europe)37  109 ATRA → Chemo 95 8  75 
 99 ATRA + Chemo 94 7 32 86 
North American Intergroup38  172 ATRA 72 11 56 67 
 174 Chemo 69 14 50 32 
TrialNInduction% CR% ED% ED due to hemorrhage% DFS/EFS
Abbreviations: CR, complete remission; ED, early death; DFS, disease-free survival; EFS, event-free survival 
APL91 (Europe)35  54 ATRA + Chemo 97 9 60 79 
 47 Chemo 81 8 75 50 
APL93 (Europe)37  109 ATRA → Chemo 95 8  75 
 99 ATRA + Chemo 94 7 32 86 
North American Intergroup38  172 ATRA 72 11 56 67 
 174 Chemo 69 14 50 32 
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