Table 2. Salvage chemotherapy regimens... | American Society of Hematology

Table 2.

Salvage chemotherapy regimens in relapsed or refractory Hodgkin lymphoma.

Regimen	No. of patients	CR,% 95% CI	PR,% 95% CI	ORR, % 95% CI	Grade 3/4 NEUT, %	Grade 3/4 TCP, %	Grade 3/4 VOM, %	Toxic deaths, % 95% CI
*mucositis reported in 9%
†all patients experience grade IV neutropenia
‡5% toxic death rate included patients undergoing ASCT
Chemotherapy regimens: BEAM, BCNU, etoposide, ara-C, melphalan; ICE, ifosfamide, carboplatin, etoposide, DHAP, dexamethasone, ara-C, cisplatin; GDP, gemcitabine, dexamethasone, cisplatin; GVD, gemcitabine, vinorelbine, doxil (liposomal doxorubicin); IEV, ifosfamide, etoposide, vinorelbine; MINE, mitoguazone, ifosfamide, vinorelbine, etoposide; IV, ifosfamide, vinorelbine.
NS indicates not stated; NEUT, neutropenia, TCP, thrombocytopenia; VOM, vomiting
Dexa-BEAM²²	144	27	54	81	NS	NS	NS	5
		20–34	46–62	75–87				1–9
Mini-BEAM²⁵	55	49	33	82	86	60	NS	2
		35–63	21–47	69–91				0.1–10
ICE⁶⁷	65	26	59	85	NS	NS	NS	0
		16–39	46–71	74–92				0–5
DHAP q2wk²⁸	102	21	68	89	88	69	26	0
		13–29	59–77	83–95				0–4
GDP²⁹	23	17	52	69	9	13	13	0
		5–39	31–73	47–87				0–15
GVD*⁶⁸	91	19	51	70	63	14	0	0
IEV³²	51	76		84	100†	NS	NS	0
		60–88		71–93
MINE³¹	157	NS	NS	75	NS	NS	NS	5
		64–84
IV³³^,⁶⁹	47	45	38	83	65	0	2	NS
		30–60	25–54	69–92

Regimen	No. of patients	CR,% 95% CI	PR,% 95% CI	ORR, % 95% CI	Grade 3/4 NEUT, %	Grade 3/4 TCP, %	Grade 3/4 VOM, %	Toxic deaths, % 95% CI
*mucositis reported in 9%
†all patients experience grade IV neutropenia
‡5% toxic death rate included patients undergoing ASCT
Chemotherapy regimens: BEAM, BCNU, etoposide, ara-C, melphalan; ICE, ifosfamide, carboplatin, etoposide, DHAP, dexamethasone, ara-C, cisplatin; GDP, gemcitabine, dexamethasone, cisplatin; GVD, gemcitabine, vinorelbine, doxil (liposomal doxorubicin); IEV, ifosfamide, etoposide, vinorelbine; MINE, mitoguazone, ifosfamide, vinorelbine, etoposide; IV, ifosfamide, vinorelbine.
NS indicates not stated; NEUT, neutropenia, TCP, thrombocytopenia; VOM, vomiting
Dexa-BEAM²²	144	27	54	81	NS	NS	NS	5
		20–34	46–62	75–87				1–9
Mini-BEAM²⁵	55	49	33	82	86	60	NS	2
		35–63	21–47	69–91				0.1–10
ICE⁶⁷	65	26	59	85	NS	NS	NS	0
		16–39	46–71	74–92				0–5
DHAP q2wk²⁸	102	21	68	89	88	69	26	0
		13–29	59–77	83–95				0–4
GDP²⁹	23	17	52	69	9	13	13	0
		5–39	31–73	47–87				0–15
GVD*⁶⁸	91	19	51	70	63	14	0	0
IEV³²	51	76		84	100†	NS	NS	0
		60–88		71–93
MINE³¹	157	NS	NS	75	NS	NS	NS	5
		64–84
IV³³^,⁶⁹	47	45	38	83	65	0	2	NS
		30–60	25–54	69–92