Variation in cytogenetic risk group classification across clinical trial groups. References for the various classification systems can be found in Grimwade.1 The HOVON/SAKK cytogenetic classification was derived from the study by Cornelissen et al.4 The revised MRC classification system was based on an analysis of 5635 patients aged 16 to 59 years enrolled in the MRC AML10, AML12 and AML15 trials.6
| . | Original MRC . | SWOG/ECOG . | CALGB . | GIMEMA/AML10 . | German AMLCG . | HOVON/SAKK . | Refined MRC . |
|---|---|---|---|---|---|---|---|
| Unrel abn indicates unrelated abnormality; abn, abnormal. | |||||||
| Favorable | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) [lacking del(9q), complex, ie, ≥ 3 unrel abn] inv(16)/t(16;16)/del(16q) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) alone inv/del(16) and lacking unfav abn | t(15;17) t(8;21) inv(16)/t(16;16) |
| Intermediate | Normal Other non-complex | Normal +6, +8, -Y, del(12p) | Normal Other non- complex | Normal -Y | Normal Other non- complex | Normal Other non- complex | Normal Other non- complex |
| Adverse | abn(3q) -5/del(5q) -7 complex [≥ 5 unrel abn] Excluding those with favorable changes | abn(3q),(9q),(11q),(21q) abn(17p) -5/del(5q) -7/del(7q) t(6;9) t(9;22) complex [≥3 unrel abn] | inv(3)/t(3;3) -7 t(6;9) t(6;11) t(11;19) +8 complex (≥ 3 unrel abn) Excluding those with favorable changes | Other | inv(3)/t(3;3) -5/del(5q) -7/del(7q) abn(11q23) del(12p) abn(17p) complex (≥ 3 unrel abn) | abn(3q) -5/del(5q) -7/del(7q) abn(11q23) t(6;9) t(9;22) complex (≥ 3 unrel abn) | abn(3q) [excluding t(3;5)] inv(3)/t(3;3) add(5q)/del(5q)/ -5,-7/add(7q) t(6;11) t(10;11) t(9;22) -17 abn(17p) with other changes Complex (> 3 unrel abn) Excluding those with favorable changes |
| . | Original MRC . | SWOG/ECOG . | CALGB . | GIMEMA/AML10 . | German AMLCG . | HOVON/SAKK . | Refined MRC . |
|---|---|---|---|---|---|---|---|
| Unrel abn indicates unrelated abnormality; abn, abnormal. | |||||||
| Favorable | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) [lacking del(9q), complex, ie, ≥ 3 unrel abn] inv(16)/t(16;16)/del(16q) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) inv(16)/t(16;16) | t(15;17) t(8;21) alone inv/del(16) and lacking unfav abn | t(15;17) t(8;21) inv(16)/t(16;16) |
| Intermediate | Normal Other non-complex | Normal +6, +8, -Y, del(12p) | Normal Other non- complex | Normal -Y | Normal Other non- complex | Normal Other non- complex | Normal Other non- complex |
| Adverse | abn(3q) -5/del(5q) -7 complex [≥ 5 unrel abn] Excluding those with favorable changes | abn(3q),(9q),(11q),(21q) abn(17p) -5/del(5q) -7/del(7q) t(6;9) t(9;22) complex [≥3 unrel abn] | inv(3)/t(3;3) -7 t(6;9) t(6;11) t(11;19) +8 complex (≥ 3 unrel abn) Excluding those with favorable changes | Other | inv(3)/t(3;3) -5/del(5q) -7/del(7q) abn(11q23) del(12p) abn(17p) complex (≥ 3 unrel abn) | abn(3q) -5/del(5q) -7/del(7q) abn(11q23) t(6;9) t(9;22) complex (≥ 3 unrel abn) | abn(3q) [excluding t(3;5)] inv(3)/t(3;3) add(5q)/del(5q)/ -5,-7/add(7q) t(6;11) t(10;11) t(9;22) -17 abn(17p) with other changes Complex (> 3 unrel abn) Excluding those with favorable changes |