Table 1. Translocation and cyclin D (TC)... | American Society of Hematology

Table 1.

Translocation and cyclin D (TC) groups.

Group	Primary Translocation	Gene(s) at Breakpoint	D-Cyclin	Ploidy*	Proliferation Index	Bone Disease (% MRI Pos)	Frequency (%)	Prognosis
Abbreviations: D, diploid; H, hyperdiploid; NH, non-hyperdiploid
6p21	6p21	CCND3	D3	NH	Average	100	3	? Good
11q13	11q13	CCND1	D1	D = NH	Average	94	16	Good
D1	None	None	D1	H	Low	86	34	Good
D1+D2	None	None	D1 and D2	H	High	100	6	? Poor
D2	None	None	D2	H = NH	Average	67	17	?
None	None	None	None	NH	Average	100	2	? Good
4p16	4p16	FGFR3/MMSET	D2	NH > H	Average	57	15	Poor
Maf	16q23/20q11	c-maf/mafB	D2	NH	High	55	52	Poor

Group	Primary Translocation	Gene(s) at Breakpoint	D-Cyclin	Ploidy*	Proliferation Index	Bone Disease (% MRI Pos)	Frequency (%)	Prognosis
Abbreviations: D, diploid; H, hyperdiploid; NH, non-hyperdiploid
6p21	6p21	CCND3	D3	NH	Average	100	3	? Good
11q13	11q13	CCND1	D1	D = NH	Average	94	16	Good
D1	None	None	D1	H	Low	86	34	Good
D1+D2	None	None	D1 and D2	H	High	100	6	? Poor
D2	None	None	D2	H = NH	Average	67	17	?
None	None	None	None	NH	Average	100	2	? Good
4p16	4p16	FGFR3/MMSET	D2	NH > H	Average	57	15	Poor
Maf	16q23/20q11	c-maf/mafB	D2	NH	High	55	52	Poor