Table 2.

Chemokines expressed in Reed-Sternberg cells.

  • TARC (CCL17) (Thymus and Activation Regulated Chemokine)

    • Normal expression: dendritic cells

    • Attracts: Th2-like T cells with CCR4 receptor

  • MDC (CCL22) (Macrophage Derived Chemokine)

    • Normal expression: dendritic cells, macrophages

    • Attracts: Th2-like T cells with CCR4 receptor

  • IP-10 (CXCL10) (Interferon γ-inducible protein 10); Epstein-

    • Barr virus (EBV)-positive HL

    • Normal expression: macrophages, endothelial cells

    • Attracts: stimulated T and natural killer (NK) cells with CXCR3 receptor

  • RANTES (CCL5) (Regulated on Activation Normal

    • T cell Expressed and Secreted); EBV-positive Hodgkin lymphoma

    • Normal expression: activated T lymphocytes

    • Attracts: monocytes, T lymphocytes and eosinophils with CCR1, CCR3, CCR5

  • MCP-4 (CCL 13) (Monocyte Chemoattractant Protein 4)

    • Normal expression: monocytes, epithelial cells

    • Attracts: eosinophils with CCR2 and CCR3

 
  • TARC (CCL17) (Thymus and Activation Regulated Chemokine)

    • Normal expression: dendritic cells

    • Attracts: Th2-like T cells with CCR4 receptor

  • MDC (CCL22) (Macrophage Derived Chemokine)

    • Normal expression: dendritic cells, macrophages

    • Attracts: Th2-like T cells with CCR4 receptor

  • IP-10 (CXCL10) (Interferon γ-inducible protein 10); Epstein-

    • Barr virus (EBV)-positive HL

    • Normal expression: macrophages, endothelial cells

    • Attracts: stimulated T and natural killer (NK) cells with CXCR3 receptor

  • RANTES (CCL5) (Regulated on Activation Normal

    • T cell Expressed and Secreted); EBV-positive Hodgkin lymphoma

    • Normal expression: activated T lymphocytes

    • Attracts: monocytes, T lymphocytes and eosinophils with CCR1, CCR3, CCR5

  • MCP-4 (CCL 13) (Monocyte Chemoattractant Protein 4)

    • Normal expression: monocytes, epithelial cells

    • Attracts: eosinophils with CCR2 and CCR3

 
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