Ongoing randomized trials of reduced-intensity regimens in North America.
| Organization . | Disease . | Study . | Question Being Asked . |
|---|---|---|---|
| BMT-CTN 01-02 | Myeloma | Phase III randomized study of tandem autologous stem cell transplantation with or without maintenance therapy after the second transplantation versus single autologous stem cell transplantation followed by matched sibling nonmyeloablative allogeneic stem cell transplantation in patients with stage II or III multiple myeloma | Role of a graft-versus-myeloma effect in achieving long term disease control |
| BMT-CTN 02-02 | Follicular lymphoma | Phase II/III study of autologous hematopoietic stem cell transplantation (HSCT) or non-myeloablative allogeneic HSCT from a HLA-matched sibling donor in patients with recurrent grade I or II follicular non-Hodgkin’s lymphoma | Role of a graft-versus-lymphoma effect in achieving long term disease control |
| FHCRC-1813.00 | Various | Phase III randomized study of nonmyeloablative conditioning comprising low-dose total body irradiation with versus without fludarabine followed by HLA-matched related allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies at low or moderate risk for graft rejection | Role of fludarabine in engraftment and graft-versus-host disease (GVHD) after a reduced-intensity regimen with 200 cGy of total body irradiation (TBI) |
| Organization . | Disease . | Study . | Question Being Asked . |
|---|---|---|---|
| BMT-CTN 01-02 | Myeloma | Phase III randomized study of tandem autologous stem cell transplantation with or without maintenance therapy after the second transplantation versus single autologous stem cell transplantation followed by matched sibling nonmyeloablative allogeneic stem cell transplantation in patients with stage II or III multiple myeloma | Role of a graft-versus-myeloma effect in achieving long term disease control |
| BMT-CTN 02-02 | Follicular lymphoma | Phase II/III study of autologous hematopoietic stem cell transplantation (HSCT) or non-myeloablative allogeneic HSCT from a HLA-matched sibling donor in patients with recurrent grade I or II follicular non-Hodgkin’s lymphoma | Role of a graft-versus-lymphoma effect in achieving long term disease control |
| FHCRC-1813.00 | Various | Phase III randomized study of nonmyeloablative conditioning comprising low-dose total body irradiation with versus without fludarabine followed by HLA-matched related allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies at low or moderate risk for graft rejection | Role of fludarabine in engraftment and graft-versus-host disease (GVHD) after a reduced-intensity regimen with 200 cGy of total body irradiation (TBI) |