Hematologic parameters from PAR-2+/+ or PAR-2−/− mice transplanted with bone marrow from WT or sickle BERK (SS) mice
| Variable . | WT/PAR-2+/+ . | WT/PAR-2−/− . | SS/PAR-2+/+ . | SS/PAR-2−/− . |
|---|---|---|---|---|
| RBC (106/µL) | 8.2 ± 0.7 | 8.6 ± 0.36 | 5.4 ± 0.7*** | 5.4 ± 0.6*** |
| Hematocrit (%) | 38.3 ± 3.4 | 40.5 ± 1.6 | 27.3 ± 5.2*** | 25.4 ± 3.6*** |
| RDW (%) | 17.0 ± 0.7 | 16.6 ± 0.3 | 31.7 ± 2.4*** | 31.9 ± 4.4*** |
| Wbc (103/µL) | 12.9 ± 4.7 | 15.5 ± 4.7 | 19.4 ± 5.4* | 19.1 ± 4.3 |
| Neutrophil (103/µL) | 2.2 ± 1.3 | 1.9 ± 0.8 | 5.38 ± 4.6* | 1.96 ± 0.5# |
| Lymphocyte (103/µL) | 10.5 ± 3.6 | 13.3 ± 3.9 | 13.0 ± 3.7 | 16.4 ± 4.0 |
| Monocyte (103/µL) | 0.31 ± 0.16 | 0.04 ± 0.05 | 0.96 ± 0.3*** | 0.92 ± 0.3*** |
| Platelet (103/µL) | 788 ± 84 | 734 ± 29 | 894 ± 161 | 914 ± 141* |
| Variable . | WT/PAR-2+/+ . | WT/PAR-2−/− . | SS/PAR-2+/+ . | SS/PAR-2−/− . |
|---|---|---|---|---|
| RBC (106/µL) | 8.2 ± 0.7 | 8.6 ± 0.36 | 5.4 ± 0.7*** | 5.4 ± 0.6*** |
| Hematocrit (%) | 38.3 ± 3.4 | 40.5 ± 1.6 | 27.3 ± 5.2*** | 25.4 ± 3.6*** |
| RDW (%) | 17.0 ± 0.7 | 16.6 ± 0.3 | 31.7 ± 2.4*** | 31.9 ± 4.4*** |
| Wbc (103/µL) | 12.9 ± 4.7 | 15.5 ± 4.7 | 19.4 ± 5.4* | 19.1 ± 4.3 |
| Neutrophil (103/µL) | 2.2 ± 1.3 | 1.9 ± 0.8 | 5.38 ± 4.6* | 1.96 ± 0.5# |
| Lymphocyte (103/µL) | 10.5 ± 3.6 | 13.3 ± 3.9 | 13.0 ± 3.7 | 16.4 ± 4.0 |
| Monocyte (103/µL) | 0.31 ± 0.16 | 0.04 ± 0.05 | 0.96 ± 0.3*** | 0.92 ± 0.3*** |
| Platelet (103/µL) | 788 ± 84 | 734 ± 29 | 894 ± 161 | 914 ± 141* |
Asterisks indicate statistical difference compared with WTBM within the same genotype (*P < .05 and ***P < .001). Hash sign indicates statistical difference between SS/PAR-2+/+ and SS/PAR-2−/− (#P < .05).