Hematologic parameters from PAR-1+/+ or PAR-1−/− mice transplanted with bone marrow from WT or sickle BERK (SS) mice
| Variable . | WT/PAR-1+/+ . | WT/PAR-1−/− . | SS/PAR-1+/+ . | SS/PAR-1−/− . |
|---|---|---|---|---|
| RBC (106/µL) | 7.4 ± 0.1 | 8.1 ± 0.3 | 4.9 ± 0.3** | 4.0 ± 0.3*** |
| Hematocrit (%) | 35.3 ± 0.3 | 37.0 ± 0.6 | 26.4 ± 0.6*** | 24.6 ± 0.7*** |
| RDW (%) | 17.1 ± 0.8 | 16.2 ± 0.1 | 30.4 ± 0.5*** | 29.2 ± 0.4*** |
| WBC (103/µL) | 7.4 ± 1.9 | 10.9 ± 1.4 | 18.7 ± 1.5*** | 18.8 ± 1.9*** |
| Neutrophil (103/µL) | 1.4 ± 0.2 | 1.5 ± 0.2 | 3.9 ± 0.4* | 4.6 ± 0.9** |
| Lymphocyte (103/µL) | 5.7 ± 1.8 | 8.9 ± 1.4 | 13.5 ± 1.0*** | 12.9 ± 1.0 |
| Monocyte (103/µL) | 0.3 ± 0.04 | 0.5 ± 0.08 | 1.3 ± 0.2*** | 1.2 ± 0.1*** |
| Platelet (103/µL) | 699 ± 23 | 687 ± 21 | 690 ± 29 | 687 ± 43 |
| Variable . | WT/PAR-1+/+ . | WT/PAR-1−/− . | SS/PAR-1+/+ . | SS/PAR-1−/− . |
|---|---|---|---|---|
| RBC (106/µL) | 7.4 ± 0.1 | 8.1 ± 0.3 | 4.9 ± 0.3** | 4.0 ± 0.3*** |
| Hematocrit (%) | 35.3 ± 0.3 | 37.0 ± 0.6 | 26.4 ± 0.6*** | 24.6 ± 0.7*** |
| RDW (%) | 17.1 ± 0.8 | 16.2 ± 0.1 | 30.4 ± 0.5*** | 29.2 ± 0.4*** |
| WBC (103/µL) | 7.4 ± 1.9 | 10.9 ± 1.4 | 18.7 ± 1.5*** | 18.8 ± 1.9*** |
| Neutrophil (103/µL) | 1.4 ± 0.2 | 1.5 ± 0.2 | 3.9 ± 0.4* | 4.6 ± 0.9** |
| Lymphocyte (103/µL) | 5.7 ± 1.8 | 8.9 ± 1.4 | 13.5 ± 1.0*** | 12.9 ± 1.0 |
| Monocyte (103/µL) | 0.3 ± 0.04 | 0.5 ± 0.08 | 1.3 ± 0.2*** | 1.2 ± 0.1*** |
| Platelet (103/µL) | 699 ± 23 | 687 ± 21 | 690 ± 29 | 687 ± 43 |
Asterisks indicate statistical significance compared with WTBM mice within the same treatment (*P < .05, **P < .01, and ***P < .001). There were no statistically significant differences between PAR1+/+ and PAR1−/− mice within WTBM or SSBM.