Cross-resistance profile of HuT78 parental and romidepsin-resistant sublines to HDIs
| . | HuT78 . | DpVp35 . | DpVp50 . | DpP75 . |
|---|---|---|---|---|
| Romidepsin | 2.3 ± 0.28 nM | 250 ± 218 nM | 373 ± 162 nM | 387 ± 186 nM |
| Panobinostat | 23 ± 19 nM | 13 ± 1.6 nM | 8 ± 6 nM | 16 ± 2.3 nM |
| Vorinostat | 2 ± 0.5 µM | 1.7 ± 0.29 µM | 2.5 ± 0.51 µM | 1.6 ± 0.21 µM |
| Belinostat | 747 ± 274 nM | 550 ± 50 nM | 800 ± 141 nM | 583 ± 160 nM |
| . | HuT78 . | DpVp35 . | DpVp50 . | DpP75 . |
|---|---|---|---|---|
| Romidepsin | 2.3 ± 0.28 nM | 250 ± 218 nM | 373 ± 162 nM | 387 ± 186 nM |
| Panobinostat | 23 ± 19 nM | 13 ± 1.6 nM | 8 ± 6 nM | 16 ± 2.3 nM |
| Vorinostat | 2 ± 0.5 µM | 1.7 ± 0.29 µM | 2.5 ± 0.51 µM | 1.6 ± 0.21 µM |
| Belinostat | 747 ± 274 nM | 550 ± 50 nM | 800 ± 141 nM | 583 ± 160 nM |
Concentrations at which growth is 50% inhibited (IC50) values were determined by using the 96 Aqueous One Solution Cell Proliferation Assay kit as outlined in “Materials and methods.”