Table 1 Main clinical and laboratory... | American Society of Hematology

Table 1

Main clinical and laboratory findings of 13 HCV-positive patients with mixed cryoglobulinemia achieving sustained virological response (group A)

Pt. no.	Age at treatment, y	Sex	Durationof MC, y	Liver histologic findings	Other clinical features‡	Cryocrit, %	Cryoglobulin composition	Rheumatoid factor, IU/mL*		Complement C3/C4 level#		HCV genotype	PRE-HCVRNA (serum), IU/mL	Posttreatment HCVRNA°			Presence of t(14;18), yes/no		MC syndrome, yes/no
								Rheumatoid factor, IU/mL*		Complement C3/C4 level#				PBMC			Presence of t(14;18), yes/no		MC syndrome, yes/no
								Uncultured	Cultured with mitogens
								Uncultured	PRE	POST	PRE				POST	lymph.	macr.	PRE	POST	PRE	POST
1	54	male	5	Chronic hepatitis	Sicca syndrome, peripheral neuropathy	1	IgG+IgM(k)	35	22	64/18	104/18	2c	1.43 × 10⁴	−	+	−	no	no	yes	no
2	39	male	7	Chronic hepatitis	Peripheral neuropathy	1.5	IgG+IgM(k)	57	<20	71/20	111/20	3a	10 × 10⁵	−	+	−	yes	yes¶	yes	yes
3	65	female	15	Cirrhosis	Peripheral neuropathy, sicca syndrome, renal involvement§	11	IgG+IgM(k)	107	92	68/1	68/1	2c	1.3 × 10⁶	+	+	−	yes	yes¶	yes	yes
4	44	female	8	Chronic hepatitis	Sicca syndrome, fever	1	IgG+IgM(k)	36	<20	90/13	12718	1b	8 × 10⁵	+	+	−	yes†	yes¶	yes	yes
5	63	female	9	Chronic hepatitis	Sicca syndrome	8	IgG+IgM(k)	54	21	125/6	147/21	2c	1.17 × 10⁵	−	−	−	yes	no	yes	no
6	50	female	18	Chronic hepatitis	Peripheral neuropathy	10	IgG+IgM(k+λ)	289	90	99/16	153/30	2a	9 × 10⁵	−	−	−	yes	no	yes	no
7	50	female	15	Chronic hepatitis	Peripheral neuropathy	1	IgG+IgM(k)	30	<20	10118	101/25	1b	5.08 × 10⁵	−	+	−	no	no	yes	no
8	49	male	5	Cirrhosis	Peripheral neuropathy, sicca syndrome	1	IgG+IgM(k)	147	27	1252	169/24	1a	1.7 × 10⁴	−	−	−	yes†	no	yes	no
9	38	male	4	Chronic hepatitis	Raynaud phenomenon	5	IgG+IgM(k)	39	<20	121/24	121/24	1a	5.5 × 10⁵	−	+	−	yes	yes¶	yes	yes
10	32	male	3	Chronic hepatitis	Peripheral neuropathy, sicca syndrome	1	IgG+IgM(k+λ)	244	26	8617	107/31	2c	7.5 × 10⁵	−	−	+	yes	yes¶	yes	yes
11	49	female	7	Chronic hepatitis	Sicca syndrome, dermatomyositis	2	IgG+IgM(k)	100	50	138/17	175/32	4c/d	7.47 × 10⁵	−	−	−	yes	yes¶	yes	yes
12	41	female	5	Chronic hepatitis	Dermatomyositis	1.5	IgG+IgM(k)	40	<20	103/13	110/30	1b	1.4 × 10⁶	−	−	+	yes	yes¶	yes	yes
13	60	female	11	Chronic hepatitis	Peripheral neuropathy, Raynaud phenomenon, renal involvement§	2	IgG+IgM(k)	4380	130	167/11	148/25	1b	6.5 × 10⁵	−	−	−	no	no	yes	no

Pt. no.	Age at treatment, y	Sex	Durationof MC, y	Liver histologic findings	Other clinical features‡	Cryocrit, %	Cryoglobulin composition	Rheumatoid factor, IU/mL*		Complement C3/C4 level#		HCV genotype	PRE-HCVRNA (serum), IU/mL	Posttreatment HCVRNA°			Presence of t(14;18), yes/no		MC syndrome, yes/no
								Rheumatoid factor, IU/mL*		Complement C3/C4 level#				PBMC			Presence of t(14;18), yes/no		MC syndrome, yes/no
								Uncultured	Cultured with mitogens
								Uncultured	PRE	POST	PRE				POST	lymph.	macr.	PRE	POST	PRE	POST
1	54	male	5	Chronic hepatitis	Sicca syndrome, peripheral neuropathy	1	IgG+IgM(k)	35	22	64/18	104/18	2c	1.43 × 10⁴	−	+	−	no	no	yes	no
2	39	male	7	Chronic hepatitis	Peripheral neuropathy	1.5	IgG+IgM(k)	57	<20	71/20	111/20	3a	10 × 10⁵	−	+	−	yes	yes¶	yes	yes
3	65	female	15	Cirrhosis	Peripheral neuropathy, sicca syndrome, renal involvement§	11	IgG+IgM(k)	107	92	68/1	68/1	2c	1.3 × 10⁶	+	+	−	yes	yes¶	yes	yes
4	44	female	8	Chronic hepatitis	Sicca syndrome, fever	1	IgG+IgM(k)	36	<20	90/13	12718	1b	8 × 10⁵	+	+	−	yes†	yes¶	yes	yes
5	63	female	9	Chronic hepatitis	Sicca syndrome	8	IgG+IgM(k)	54	21	125/6	147/21	2c	1.17 × 10⁵	−	−	−	yes	no	yes	no
6	50	female	18	Chronic hepatitis	Peripheral neuropathy	10	IgG+IgM(k+λ)	289	90	99/16	153/30	2a	9 × 10⁵	−	−	−	yes	no	yes	no
7	50	female	15	Chronic hepatitis	Peripheral neuropathy	1	IgG+IgM(k)	30	<20	10118	101/25	1b	5.08 × 10⁵	−	+	−	no	no	yes	no
8	49	male	5	Cirrhosis	Peripheral neuropathy, sicca syndrome	1	IgG+IgM(k)	147	27	1252	169/24	1a	1.7 × 10⁴	−	−	−	yes†	no	yes	no
9	38	male	4	Chronic hepatitis	Raynaud phenomenon	5	IgG+IgM(k)	39	<20	121/24	121/24	1a	5.5 × 10⁵	−	+	−	yes	yes¶	yes	yes
10	32	male	3	Chronic hepatitis	Peripheral neuropathy, sicca syndrome	1	IgG+IgM(k+λ)	244	26	8617	107/31	2c	7.5 × 10⁵	−	−	+	yes	yes¶	yes	yes
11	49	female	7	Chronic hepatitis	Sicca syndrome, dermatomyositis	2	IgG+IgM(k)	100	50	138/17	175/32	4c/d	7.47 × 10⁵	−	−	−	yes	yes¶	yes	yes
12	41	female	5	Chronic hepatitis	Dermatomyositis	1.5	IgG+IgM(k)	40	<20	103/13	110/30	1b	1.4 × 10⁶	−	−	+	yes	yes¶	yes	yes
13	60	female	11	Chronic hepatitis	Peripheral neuropathy, Raynaud phenomenon, renal involvement§	2	IgG+IgM(k)	4380	130	167/11	148/25	1b	6.5 × 10⁵	−	−	−	no	no	yes	no

Pt. no. indicates patient number; PRE, pretreatment; POST, posttreatment; lymph., lymphocytes; macr., macrophages; −, negative; and +, positive.

Normal value are < 25 UL/mL.

Normal values are 83 to 177 mL/dL for complement C3 and 20 to 150 mL/dL for complement C4.

†

T(14;18) determined in both peripheral blood and bone marrow mononuclear cells.

‡

Other clinical features: MC-related manifestations observed in addition to the classic Meltzer syndrome.

Renal involvement was in both cases shown by microscopic hematuria, proteinuria below the nephrotic range (<3 g/24 h), with normal or only fairly reduced renal function (creatinine <1.5 mg%).

Identical N-segments in the pre- and posttreatment samples were observed.

°Posttreatment HCVRNA in serum and liver samples was persistently negative.

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