Number of patients with infectious episodes CTC grade 3 or 4 (percentages), by daily dose cytarabine and by cycle number
| Infection . | Cytarabine 200 mg/m2, dose levels I, II, IIIA, IVA . | Cytarabine 1000 mg/m2, dose levels IIIB, IVB, V . | ||
|---|---|---|---|---|
| Cycle 1, n = 107 (%) . | Cycle 2, n = 96 (%) . | Cycle 1, n = 55 (%) . | Cycle 2, n = 44 (%) . | |
| Any | 36 (34) | 23 (24) | 44 (80) | 24 (55) |
| Fever of unknown origin | 17 (16) | 9 (9) | 23 (42) | 7 (16) |
| Blood | ||||
| Staphylococcus | 1 (1) | 0 | 6 (11) | 4 (9) |
| Streptococcus | 2 (2) | 0 | 4 (7) | 2 (5) |
| Pseudomonas aeruginosa | 0 | 0 | 1 (2) | 1 (2) |
| Other/unknown | 0 | 1 (1) | 2 (4) | 2 (5) |
| Gastrointestinal tract | 4 (4) | 3 (3) | 8 (15) | 8 (18) |
| Ear/nose/throat | 7 (7) | 6 (6) | 4 (7) | 2 (5) |
| Skin/subcutaneous | 5 (5) | 3 (3) | 1 (2) | 2 (5) |
| Pulmonary | ||||
| Aspergillus | 0 | 1 (1) | 3 (5) | 1 (2) |
| Streptococcus | 1 (1) | 0 | 1 (2) | 0 |
| Other/unknown | 3 (3) | 0 | 4 (7) | 0 |
| Catheter | 1 (1) | 1 (1) | 2 (4) | 5 (11) |
| Genitourinary tract | 2 (2) | 1 (1) | 2 (4) | 2 (5) |
| Other | 2 (2) | 3 (3) | 0 | 2 (5) |
| Infection . | Cytarabine 200 mg/m2, dose levels I, II, IIIA, IVA . | Cytarabine 1000 mg/m2, dose levels IIIB, IVB, V . | ||
|---|---|---|---|---|
| Cycle 1, n = 107 (%) . | Cycle 2, n = 96 (%) . | Cycle 1, n = 55 (%) . | Cycle 2, n = 44 (%) . | |
| Any | 36 (34) | 23 (24) | 44 (80) | 24 (55) |
| Fever of unknown origin | 17 (16) | 9 (9) | 23 (42) | 7 (16) |
| Blood | ||||
| Staphylococcus | 1 (1) | 0 | 6 (11) | 4 (9) |
| Streptococcus | 2 (2) | 0 | 4 (7) | 2 (5) |
| Pseudomonas aeruginosa | 0 | 0 | 1 (2) | 1 (2) |
| Other/unknown | 0 | 1 (1) | 2 (4) | 2 (5) |
| Gastrointestinal tract | 4 (4) | 3 (3) | 8 (15) | 8 (18) |
| Ear/nose/throat | 7 (7) | 6 (6) | 4 (7) | 2 (5) |
| Skin/subcutaneous | 5 (5) | 3 (3) | 1 (2) | 2 (5) |
| Pulmonary | ||||
| Aspergillus | 0 | 1 (1) | 3 (5) | 1 (2) |
| Streptococcus | 1 (1) | 0 | 1 (2) | 0 |
| Other/unknown | 3 (3) | 0 | 4 (7) | 0 |
| Catheter | 1 (1) | 1 (1) | 2 (4) | 5 (11) |
| Genitourinary tract | 2 (2) | 1 (1) | 2 (4) | 2 (5) |
| Other | 2 (2) | 3 (3) | 0 | 2 (5) |