Well-designed clinical studies of ABO distributions and clinical severity of P falciparum infection44,,–47
| Author/year/locale . | Sample size . | Focus . | Findings . |
|---|---|---|---|
| Fischer et al40 /1998/Zimbabwe | 209 mild malaria outpatients vs 280 severe malaria inpatients | Coma and anemia severity by blood group | Coma in 3% of group non-A vs 9% of group A, P = .008 |
| Lell et al41 /1999/Gabon | 100 mild malaria cases vs 100 severe malaria cases | Proportion of severe cases among ABO blood groups | Group O: 46% severe group A: 71% severe, P < .01 |
| Pathirana et al42 /2005/Sri Lanka | 243 malaria cases (163 mild, 80 severe) and 65 nonmalarial controls with other infections | Blood group distributions among the mild vs severe, odds ratio for severe malaria if group O vs. non-O | Blood group, mild/severe: group O, 48%/24%; group B, 23%/28%; group A, 25%/33%; group AB, 5%/16%; P < .001; odds ratio (severe malaria:controls) for group O status, 0.37; P < .001 |
| Loscertales et al43 /2006/The Gambia | 41 primiparae with active placental infection. | Maternal and infant hemoglobin; infant weight and size; placental weight; placental parasite count | Placental weight group O, 2893 g; non–group O, 2639 g; P = .04 |
| Author/year/locale . | Sample size . | Focus . | Findings . |
|---|---|---|---|
| Fischer et al40 /1998/Zimbabwe | 209 mild malaria outpatients vs 280 severe malaria inpatients | Coma and anemia severity by blood group | Coma in 3% of group non-A vs 9% of group A, P = .008 |
| Lell et al41 /1999/Gabon | 100 mild malaria cases vs 100 severe malaria cases | Proportion of severe cases among ABO blood groups | Group O: 46% severe group A: 71% severe, P < .01 |
| Pathirana et al42 /2005/Sri Lanka | 243 malaria cases (163 mild, 80 severe) and 65 nonmalarial controls with other infections | Blood group distributions among the mild vs severe, odds ratio for severe malaria if group O vs. non-O | Blood group, mild/severe: group O, 48%/24%; group B, 23%/28%; group A, 25%/33%; group AB, 5%/16%; P < .001; odds ratio (severe malaria:controls) for group O status, 0.37; P < .001 |
| Loscertales et al43 /2006/The Gambia | 41 primiparae with active placental infection. | Maternal and infant hemoglobin; infant weight and size; placental weight; placental parasite count | Placental weight group O, 2893 g; non–group O, 2639 g; P = .04 |