Table 5

Disease severity scores for different clinical profiles

VariableProfile 1Profile 2Profile 3Profile 4Profile 5Profile 6
ACS No No Yes No No No 
Age, y 2–18 2–18 2–18 18–40 18–40 18–40 
Bilirubin level Normal Normal High Normal Normal Normal 
Blood transfusion No No No No No No 
LDH level Normal Normal High Normal Normal Normal 
MCV Normal Normal Normal Normal High High 
Pain No Yes No Yes Yes Yes 
Priapism No No NA No No No 
Reticulocyte count Normal Low Normal Low High Normal 
Sepsis No No Yes No No Yes 
Sex Male Male Female Male Male Male 
Stroke No Yes No Yes Yes Yes 
Sys BP Normal Normal Normal Normal Normal Normal 
WBC count Normal Normal Normal Normal Very high Very high 
Disease severity score 0.04 0.116 0.581 0.64 0.76 1.00 
VariableProfile 1Profile 2Profile 3Profile 4Profile 5Profile 6
ACS No No Yes No No No 
Age, y 2–18 2–18 2–18 18–40 18–40 18–40 
Bilirubin level Normal Normal High Normal Normal Normal 
Blood transfusion No No No No No No 
LDH level Normal Normal High Normal Normal Normal 
MCV Normal Normal Normal Normal High High 
Pain No Yes No Yes Yes Yes 
Priapism No No NA No No No 
Reticulocyte count Normal Low Normal Low High Normal 
Sepsis No No Yes No No Yes 
Sex Male Male Female Male Male Male 
Stroke No Yes No Yes Yes Yes 
Sys BP Normal Normal Normal Normal Normal Normal 
WBC count Normal Normal Normal Normal Very high Very high 
Disease severity score 0.04 0.116 0.581 0.64 0.76 1.00 

As some examples of how the severity score calculated by the network model (Figure 1) is dependent on the variables in the network, the table shows that the occurrence of stroke is associated with a wide severity spectrum, according to changes in laboratory variables, age, and other complications. Note that while sepsis is a very strong indicator of disease severity, its contribution to severity changes according to the other variables in the network (see the severity scores of profiles 3 and 6).

NA indicates not applicable.

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