Frequencies of donor vs recipient alloreactive NK clones in randomly assayed NK alloreactive donors and their transplant recipients, along with the KIR ligand mismatch
| Transplant pairs . | Isolated in donor, n (%) . | Isolated after transplant in recipient . | Missing donor KIR ligand in recipient . | ||
|---|---|---|---|---|---|
| 1-3 mo . | 4-7 mo . | 8-12 mo . | |||
| 1 | 5/24 (20.8) | 0/100 | ND | ND | HLA-C 2 |
| 2 | 8/14 (57.1) | 0/50 | ND | ND | HLA-Bw4 |
| 3 | 12/40 (30) | 0/40 | ND | ND | HLA-Bw4 |
| 4 | 4/25 (16) | 0/30 | ND | ND | HLA-C 1 |
| 5 | 6/36 (16.7) | 0/35 | ND | ND | HLA-C 1 |
| 6 | 2/40 (5) | 0/54 | ND | ND | HLA-C 2 |
| 7 | 12/20 (60) | 4/22 (18.2) | 0/48 | ND | HLA-C 1 |
| 8 | 2/33 (6.1) | 4/30 (13.3) | 0/35 | ND | HLA-C 1 |
| 9 | 3/75 (4) | 4/100 (4) | 0/52 | ND | HLA-Bw4 |
| 10 | 1/40 (2.5) | 1/40 (2.5) | 0/55 | ND | HLA-C 2 |
| 11 | 3/40 (7.5) | 2/45 (4.4) | 0/60 | ND | HLA-C 1 |
| 12 | 3/25 (12) | 2/17 (11.8) | ND | ND | HLA-C1 + HLA-Bw4 |
| 13 | 2/11 (18.2) | 2/37 (5.4) | ND | ND | HLA-C 2 |
| 14 | 1/41 (2.4) | 2/42 (4.8) | ND | ND | HLA-C 1 |
| 15 | 6/60 (10) | 2/45 (4.4) | 4/96 (4.2) | 2/80 (2.5) | HLA-C 2 |
| 16 | 6/30 (20) | 1/48 (2.1) | 2/47 (4.2) | 0/60 | HLA-C 1 |
| 17 | 2/48 (4.2) | 8/90 (8.9) | 5/48 (10.4) | 2/54 (3.7) | HLA-C 1 |
| 18 | 10/57 (17.5) | 4/66 (6.1) | 1/96 (1.1) | 0/86 | HLA-C 2 |
| 19 | 8/65 (12.3) | 4/97 (4.1) | 4/64 (6.2) | 0/58 | HLA-C 1 |
| 20 | 3/45 (6.7) | 0/90 | 0/113 | 0/130 | HLA-C 1 |
| 21 | 6/80 (7.5) | 2/36 (5.5) | 1/86 (1.2) | 0/97 | HLA-C 2 |
| 22 | 5/87 (5.7) | 20/78 (25.6) | 0/65 | ND | HLA-C 1 |
| 23 | 8/69 (11.6) | 10/46 (21.7) | 30/75 (40) | 0/79 | HLA-C 2 |
| 24 | 2/64 (3.1) | 3/43 (7) | 0/34 | 0/65 | HLA-Bw4 |
| Transplant pairs . | Isolated in donor, n (%) . | Isolated after transplant in recipient . | Missing donor KIR ligand in recipient . | ||
|---|---|---|---|---|---|
| 1-3 mo . | 4-7 mo . | 8-12 mo . | |||
| 1 | 5/24 (20.8) | 0/100 | ND | ND | HLA-C 2 |
| 2 | 8/14 (57.1) | 0/50 | ND | ND | HLA-Bw4 |
| 3 | 12/40 (30) | 0/40 | ND | ND | HLA-Bw4 |
| 4 | 4/25 (16) | 0/30 | ND | ND | HLA-C 1 |
| 5 | 6/36 (16.7) | 0/35 | ND | ND | HLA-C 1 |
| 6 | 2/40 (5) | 0/54 | ND | ND | HLA-C 2 |
| 7 | 12/20 (60) | 4/22 (18.2) | 0/48 | ND | HLA-C 1 |
| 8 | 2/33 (6.1) | 4/30 (13.3) | 0/35 | ND | HLA-C 1 |
| 9 | 3/75 (4) | 4/100 (4) | 0/52 | ND | HLA-Bw4 |
| 10 | 1/40 (2.5) | 1/40 (2.5) | 0/55 | ND | HLA-C 2 |
| 11 | 3/40 (7.5) | 2/45 (4.4) | 0/60 | ND | HLA-C 1 |
| 12 | 3/25 (12) | 2/17 (11.8) | ND | ND | HLA-C1 + HLA-Bw4 |
| 13 | 2/11 (18.2) | 2/37 (5.4) | ND | ND | HLA-C 2 |
| 14 | 1/41 (2.4) | 2/42 (4.8) | ND | ND | HLA-C 1 |
| 15 | 6/60 (10) | 2/45 (4.4) | 4/96 (4.2) | 2/80 (2.5) | HLA-C 2 |
| 16 | 6/30 (20) | 1/48 (2.1) | 2/47 (4.2) | 0/60 | HLA-C 1 |
| 17 | 2/48 (4.2) | 8/90 (8.9) | 5/48 (10.4) | 2/54 (3.7) | HLA-C 1 |
| 18 | 10/57 (17.5) | 4/66 (6.1) | 1/96 (1.1) | 0/86 | HLA-C 2 |
| 19 | 8/65 (12.3) | 4/97 (4.1) | 4/64 (6.2) | 0/58 | HLA-C 1 |
| 20 | 3/45 (6.7) | 0/90 | 0/113 | 0/130 | HLA-C 1 |
| 21 | 6/80 (7.5) | 2/36 (5.5) | 1/86 (1.2) | 0/97 | HLA-C 2 |
| 22 | 5/87 (5.7) | 20/78 (25.6) | 0/65 | ND | HLA-C 1 |
| 23 | 8/69 (11.6) | 10/46 (21.7) | 30/75 (40) | 0/79 | HLA-C 2 |
| 24 | 2/64 (3.1) | 3/43 (7) | 0/34 | 0/65 | HLA-Bw4 |
Number of donor vs recipient alloreactive NK clones (ie, killing recipient PHA blasts) in number of clones tested.
ND indicates not done.