Table 1. Characteristics of CD4 T-cell... | American Society of Hematology

Table 1.

Characteristics of CD4⁺ T-cell clones

			Proliferation,^*H₃ uptake	Cytokine secretion^*
Donor/name	Restriction	Specificity	Proliferation,^*H₃ uptake		IFNγ	TNFα	IL-2	IL-4
HIV-specific CD4⁺ T-cell clones
BRE
IV-9	HLA-DRβ^*01	gag1	+	+	+	+	+
420
L11	HLA-DRβ^*04	gag2	+	+	+	+	+
N2	HLA-DRβ^*04	gag2	+	+	+	+	ND
N12	HLA-DRβ^*04	gag2	+	+	+	+	ND
F12	HLA-DRβ^*01	gag2	+	+	+	+	+
Control CD4⁺ T-cell clones
420
2.2	Unknown	Unknown	ND	–	–	–	ND
3.8	Unknown	Unknown	ND	–	–	–	ND

			Proliferation,^*H₃ uptake	Cytokine secretion^*
Donor/name	Restriction	Specificity	Proliferation,^*H₃ uptake		IFNγ	TNFα	IL-2	IL-4
HIV-specific CD4⁺ T-cell clones
BRE
IV-9	HLA-DRβ^*01	gag1	+	+	+	+	+
420
L11	HLA-DRβ^*04	gag2	+	+	+	+	+
N2	HLA-DRβ^*04	gag2	+	+	+	+	ND
N12	HLA-DRβ^*04	gag2	+	+	+	+	ND
F12	HLA-DRβ^*01	gag2	+	+	+	+	+
Control CD4⁺ T-cell clones
420
2.2	Unknown	Unknown	ND	–	–	–	ND
3.8	Unknown	Unknown	ND	–	–	–	ND

+ indicates positive; –, negative; ND, not done

Upon gag peptide stimulation. All clones secrete cytokines upon PMA/calcimycin stimulation (not shown). gag1 and gag2 correspond to Gag-p24(331-350) and Gag-p24(271-290) amino acid sequences, respectively

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