Table 1.

SNPs showing significant allelic association with chronic lymphocytic leukemia

Allelic statistic
Dominant/recessive statistics
SNP
Gene*
Substitution
MAF†
OR (95% CI)
PA
ORD/R (95% CI)‡
PD/R‡
rs1800056  ATM  F858L   0.014   2.14 (1.45, 3.16)   .0001   2.28 (1.53, 3.40)D§  < .0001D§ 
rs1800057  ATM  P1054R   0.028   1.70 (1.27, 2.27)   .0003   1.68 (1.25, 2.28)D  .0006D 
rs1801376  BUB1B  Q349R   0.308   1.21 (1.08, 1.35)   .0008   1.42 (1.12, 1.81)R  .0038R 
rs17879961  CHEK2  I157T   0.001   14.81 (1.85, ∞)   .0048   14.83 (1.85, ∞)D  .0008R 
rs10927851  FBLP-1  F191S   0.272   1.18 (1.05, 1.32)   .0058   1.44 (1.11, 1.86)R  .0055R 
rs9975588  MCM3AP  S102L   0.395   0.86 (0.77, 0.96)   .0059   0.78 (0.63, 0.96)R  .0189R 
rs1048201  NUDT6  R209Q   0.177   1.20 (1.05, 1.37)   .0065   1.26 (1.08, 1.48)D  .0029D 
rs2250889  MMP9  R574P   0.038   1.41 (1.09, 1.82)   .0085   1.44 (1.11, 1.87)D  .0064D 
rs1801265  DPYD  C29R   0.215   0.84 (0.74, 0.96)   .0097   0.82 (0.70, 0.96)D  .0113D 
rs2293925  TOP1MT  R525W   0.442   0.87 (0.78, 0.97)   .0097   0.80 (0.66, 0.96)R  .0190R 
rs4874147  ZC3HDC3  G452S   0.265   0.85 (0.76, 0.96)   .0098   0.81 (0.70, 0.94)D  .0052D 
rs7288201  GGTLA1  I475V   0.023   0.60 (0.40, 0.89)   .0106   0.58 (0.38, 0.87)D  .0072D 
rs10067  OVGP1  H604Q   0.080   1.26 (1.05, 1.51)   .0144   1.26 (1.03, 1.53)D  .0238D 
rs17409304  CLCA2  Q306E   0.345   0.87 (0.78, 0.97)   .0149   0.84 (0.73, 0.98)D  .0244D 
rs11569017  EGF  D784V   0.050   0.73 (0.56, 0.94)   .0149   0.73 (0.56, 0.96)D  .0216D 
rs3206824  DKK3  G335R   0.239   1.16 (1.03, 1.31)   .0152   1.37 (1.01, 1.84)R  .0394R 
rs144848 BRCA2  N372H   0.288   1.15 (1.03, 1.29)   .0158   1.45 (1.13, 1.86)R  .0032R 
rs4619  IGFBP1  I253M   0.355   1.14 (1.02, 1.27)   .0166   1.25 (1.01, 1.56)R  .0414R 
rs16978899  ZNF233  S247P   0.001   10.72 (1.15, ∞)   .0182   10.79 (1.16, ∞)D  .0037D 
rs712665 U2AF1L1  S155G   0.351   1.14 (1.02, 1.27)   .0185   1.21 (1.04, 1.41)D  .0117D 
rs5167  APOC4  L96R   0.339   1.14 (1.02, 1.28)   .0188   1.22 (1.04, 1.41)D  .0115D 
rs2235006  ATM  F582L   0.001   11.23 (1.25, 100)   .0189   8.43 (0.88, 81.12)D  .0269D 
rs328  LPL  S474X   0.104   0.81 (0.68, 0.97)   .0192   0.81 (0.67, 0.98)D  .0305D 
rs4150521  ERCC3  S704L   0.003   0.13 (0.02, 0.99)   .0202   0.13 (0.02, 0.99)R  .0200R 
rs10494745  CFHL4  G306E   0.102   0.81 (0.68, 0.97)   .0202   0.81 (0.67, 0.99)R  .0347D 
rs2269429  TNXB  G2555S   0.080   0.79 (0.64, 0.97)   .0211   0.79 (0.63, 0.97)D  .0268D 
rs17050550  OGG1  A85S   0.002   3.16 (1.22, 8.21)   .0228   3.17 (1.22, 8.25)R  .0124R 
rs17293607  MMP10  G65R   0.146   0.84 (0.72, 0.98)   .0248   0.83 (0.70, 0.98)D  .0293D 
rs619203 ROS1  S2229C   0.255   0.87 (0.77, 0.98)   .0261   0.85 (0.73, 0.98)D  .0284D 
rs459552 APC  V1822D   0.228   1.15 (1.02, 1.29)   .0283   1.18 (1.02, 1.37)D  .0278D 
rs508405 CAPN13  T280A   0.329   1.13 (1.01, 1.26)   .0293   1.27 (1.01, 1.60)R  .0437R 
rs3136797  POLB  P242R   0.019   1.47 (1.03, 2.10)   .0307   1.50 (1.05, 2.15)D  .0250D 
rs11102001  EPS8L3  P356S   0.061   1.26 (1.02, 1.55)   .0317   1.27 (1.02, 1.58)D  .0301D 
rs1738023  AKR7A3  D215N   0.170   1.16 (1.01, 1.33)   .0327   1.17 (1.00, 1.37)D  .0475D 
rs3821979  ShrmL  L146H   0.133   1.17 (1.01, 1.36)   .0359   1.57 (0.96, 2.54)R  .0678R 
rs1805087  MTR  D919G   0.192   1.15 (1.01, 1.31)   .0363   1.41 (0.97, 2.04)R  .0718R 
rs2452600  LIM  S136F   0.320   0.89 (0.79, 0.99)   .0369   0.80 (0.62, 1.02)R  .0756R 
rs2278106  EPHA7  P278S   0.032   1.34 (1.02, 1.78)   .0382   1.36 (1.02, 1.81)D  .0368D 
rs204900 TNXB  S873A   0.081   0.81 (0.67, 0.99)   .0395   0.80 (0.65, 0.99)D  .0397D 
rs16900023  MSH5  P786S   0.017   0.62 (0.39, 0.99)   .0410   0.62 (0.39, 0.99)D  .0440D 
rs1800100  CFTR  R668C   0.010   0.53 (0.29, 0.99)   .0415   0.53 (0.28, 0.98)R  .0404R 
rs1211554  HUS1B  Y268D   0.085   0.82 (0.67, 0.99)   .0434   0.79 (0.64, 0.97)D  .0261D 
rs2032729  ZNF24  S220N   0.080   1.21 (1.01, 1.46)   .0435   1.21 (0.99, 1.48)D  .0577D 
rs17738527  SEC14L4  E211K   0.243   0.88 (0.78, 1.00)   .0460   0.67 (0.48, 0.93)R  .0172R 
rs1799954  BRCA2  R2034C   0.006   0.43 (0.18, 1.02)   .0473   0.43 (0.18, 1.01)R  .0466R 
rs17337252  RB1CC1  M234T   0.498   1.11 (1.00, 1.23)   .0480   1.19 (1.00, 1.42)D  .0448D 
rs8207  PPIG  N699D   0.261   0.89 (0.79, 1.00)   .0481   0.65 (0.48, 0.89)R  .0063R 
rs17704912  MYO18B  W1037S   0.072   1.22 (1.00, 1.48)   .0481   1.24 (1.01, 1.53)D  .0362D 
rs3130618
 		BAT4
 		 R41L
 		 0.196
 		 1.14 (1.00, 1.30)
 		 .0482
 		 1.14 (0.98, 1.33)D
 		 .0936D
 
Allelic statistic
Dominant/recessive statistics
SNP
Gene*
Substitution
MAF†
OR (95% CI)
PA
ORD/R (95% CI)‡
PD/R‡
rs1800056  ATM  F858L   0.014   2.14 (1.45, 3.16)   .0001   2.28 (1.53, 3.40)D§  < .0001D§ 
rs1800057  ATM  P1054R   0.028   1.70 (1.27, 2.27)   .0003   1.68 (1.25, 2.28)D  .0006D 
rs1801376  BUB1B  Q349R   0.308   1.21 (1.08, 1.35)   .0008   1.42 (1.12, 1.81)R  .0038R 
rs17879961  CHEK2  I157T   0.001   14.81 (1.85, ∞)   .0048   14.83 (1.85, ∞)D  .0008R 
rs10927851  FBLP-1  F191S   0.272   1.18 (1.05, 1.32)   .0058   1.44 (1.11, 1.86)R  .0055R 
rs9975588  MCM3AP  S102L   0.395   0.86 (0.77, 0.96)   .0059   0.78 (0.63, 0.96)R  .0189R 
rs1048201  NUDT6  R209Q   0.177   1.20 (1.05, 1.37)   .0065   1.26 (1.08, 1.48)D  .0029D 
rs2250889  MMP9  R574P   0.038   1.41 (1.09, 1.82)   .0085   1.44 (1.11, 1.87)D  .0064D 
rs1801265  DPYD  C29R   0.215   0.84 (0.74, 0.96)   .0097   0.82 (0.70, 0.96)D  .0113D 
rs2293925  TOP1MT  R525W   0.442   0.87 (0.78, 0.97)   .0097   0.80 (0.66, 0.96)R  .0190R 
rs4874147  ZC3HDC3  G452S   0.265   0.85 (0.76, 0.96)   .0098   0.81 (0.70, 0.94)D  .0052D 
rs7288201  GGTLA1  I475V   0.023   0.60 (0.40, 0.89)   .0106   0.58 (0.38, 0.87)D  .0072D 
rs10067  OVGP1  H604Q   0.080   1.26 (1.05, 1.51)   .0144   1.26 (1.03, 1.53)D  .0238D 
rs17409304  CLCA2  Q306E   0.345   0.87 (0.78, 0.97)   .0149   0.84 (0.73, 0.98)D  .0244D 
rs11569017  EGF  D784V   0.050   0.73 (0.56, 0.94)   .0149   0.73 (0.56, 0.96)D  .0216D 
rs3206824  DKK3  G335R   0.239   1.16 (1.03, 1.31)   .0152   1.37 (1.01, 1.84)R  .0394R 
rs144848 BRCA2  N372H   0.288   1.15 (1.03, 1.29)   .0158   1.45 (1.13, 1.86)R  .0032R 
rs4619  IGFBP1  I253M   0.355   1.14 (1.02, 1.27)   .0166   1.25 (1.01, 1.56)R  .0414R 
rs16978899  ZNF233  S247P   0.001   10.72 (1.15, ∞)   .0182   10.79 (1.16, ∞)D  .0037D 
rs712665 U2AF1L1  S155G   0.351   1.14 (1.02, 1.27)   .0185   1.21 (1.04, 1.41)D  .0117D 
rs5167  APOC4  L96R   0.339   1.14 (1.02, 1.28)   .0188   1.22 (1.04, 1.41)D  .0115D 
rs2235006  ATM  F582L   0.001   11.23 (1.25, 100)   .0189   8.43 (0.88, 81.12)D  .0269D 
rs328  LPL  S474X   0.104   0.81 (0.68, 0.97)   .0192   0.81 (0.67, 0.98)D  .0305D 
rs4150521  ERCC3  S704L   0.003   0.13 (0.02, 0.99)   .0202   0.13 (0.02, 0.99)R  .0200R 
rs10494745  CFHL4  G306E   0.102   0.81 (0.68, 0.97)   .0202   0.81 (0.67, 0.99)R  .0347D 
rs2269429  TNXB  G2555S   0.080   0.79 (0.64, 0.97)   .0211   0.79 (0.63, 0.97)D  .0268D 
rs17050550  OGG1  A85S   0.002   3.16 (1.22, 8.21)   .0228   3.17 (1.22, 8.25)R  .0124R 
rs17293607  MMP10  G65R   0.146   0.84 (0.72, 0.98)   .0248   0.83 (0.70, 0.98)D  .0293D 
rs619203 ROS1  S2229C   0.255   0.87 (0.77, 0.98)   .0261   0.85 (0.73, 0.98)D  .0284D 
rs459552 APC  V1822D   0.228   1.15 (1.02, 1.29)   .0283   1.18 (1.02, 1.37)D  .0278D 
rs508405 CAPN13  T280A   0.329   1.13 (1.01, 1.26)   .0293   1.27 (1.01, 1.60)R  .0437R 
rs3136797  POLB  P242R   0.019   1.47 (1.03, 2.10)   .0307   1.50 (1.05, 2.15)D  .0250D 
rs11102001  EPS8L3  P356S   0.061   1.26 (1.02, 1.55)   .0317   1.27 (1.02, 1.58)D  .0301D 
rs1738023  AKR7A3  D215N   0.170   1.16 (1.01, 1.33)   .0327   1.17 (1.00, 1.37)D  .0475D 
rs3821979  ShrmL  L146H   0.133   1.17 (1.01, 1.36)   .0359   1.57 (0.96, 2.54)R  .0678R 
rs1805087  MTR  D919G   0.192   1.15 (1.01, 1.31)   .0363   1.41 (0.97, 2.04)R  .0718R 
rs2452600  LIM  S136F   0.320   0.89 (0.79, 0.99)   .0369   0.80 (0.62, 1.02)R  .0756R 
rs2278106  EPHA7  P278S   0.032   1.34 (1.02, 1.78)   .0382   1.36 (1.02, 1.81)D  .0368D 
rs204900 TNXB  S873A   0.081   0.81 (0.67, 0.99)   .0395   0.80 (0.65, 0.99)D  .0397D 
rs16900023  MSH5  P786S   0.017   0.62 (0.39, 0.99)   .0410   0.62 (0.39, 0.99)D  .0440D 
rs1800100  CFTR  R668C   0.010   0.53 (0.29, 0.99)   .0415   0.53 (0.28, 0.98)R  .0404R 
rs1211554  HUS1B  Y268D   0.085   0.82 (0.67, 0.99)   .0434   0.79 (0.64, 0.97)D  .0261D 
rs2032729  ZNF24  S220N   0.080   1.21 (1.01, 1.46)   .0435   1.21 (0.99, 1.48)D  .0577D 
rs17738527  SEC14L4  E211K   0.243   0.88 (0.78, 1.00)   .0460   0.67 (0.48, 0.93)R  .0172R 
rs1799954  BRCA2  R2034C   0.006   0.43 (0.18, 1.02)   .0473   0.43 (0.18, 1.01)R  .0466R 
rs17337252  RB1CC1  M234T   0.498   1.11 (1.00, 1.23)   .0480   1.19 (1.00, 1.42)D  .0448D 
rs8207  PPIG  N699D   0.261   0.89 (0.79, 1.00)   .0481   0.65 (0.48, 0.89)R  .0063R 
rs17704912  MYO18B  W1037S   0.072   1.22 (1.00, 1.48)   .0481   1.24 (1.01, 1.53)D  .0362D 
rs3130618
 		BAT4
 		 R41L
 		 0.196
 		 1.14 (1.00, 1.30)
 		 .0482
 		 1.14 (0.98, 1.33)D
 		 .0936D
 
*

According to NCBI Entrez Gene (http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene).

†

MAF in patients.

‡

Most significant association under a dominant (D) or recessive (R) model.

§

Globally significant after permutation testing.

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