Table 5.

Significant variables predictive of outcome on multivariable analysis




OR/HR

95% CI

P
Complete remission    
WBC   0.90*  0.85-0.96   .001  
Sex, male   0.58   0.41-0.81   .002  
Age     .043  
70-79 y   0.93  0.65-1.34   
80 y or older   0.32  0.13-0.82   
Cytogenetics     <.001  
Rare aberrations   1.41  0.56-3.54   
1 or 2 nonrare aberrations   4.80  2.91-7.92   
Disease-free survival    
WBC   1.06*  1.02-1.11   .013  
Sex, male   1.29   1.01-1.64   .040  
Age     .014  
70-79 y   1.17  0.91-1.50   
80 y or older   3.60  1.66-7.78   
Cytogenetics     <.001  
Complex ≥5   3.46§  2.07-5.78   
Overall survival    
WBC   1.05*  1.02-1.08   .002  
Sex, male   1.39   1.18-1.65   .001  
% marrow blasts   1.06  1.01-1.11   .012  
Age     .001  
70-79 y   1.23  1.04-1.47   
80 y or older   2.04  1.37-3.06   
Cytogenetics     <.001  
Complex ≥5   4.49  2.85-7.06   
Rare aberrations   2.23  1.31-3.79   
Fewer than 5 non-CBF AML, nonrare aberrations
 
1.52
 
1.03-2.25
 

 



OR/HR

95% CI

P
Complete remission    
WBC   0.90*  0.85-0.96   .001  
Sex, male   0.58   0.41-0.81   .002  
Age     .043  
70-79 y   0.93  0.65-1.34   
80 y or older   0.32  0.13-0.82   
Cytogenetics     <.001  
Rare aberrations   1.41  0.56-3.54   
1 or 2 nonrare aberrations   4.80  2.91-7.92   
Disease-free survival    
WBC   1.06*  1.02-1.11   .013  
Sex, male   1.29   1.01-1.64   .040  
Age     .014  
70-79 y   1.17  0.91-1.50   
80 y or older   3.60  1.66-7.78   
Cytogenetics     <.001  
Complex ≥5   3.46§  2.07-5.78   
Overall survival    
WBC   1.05*  1.02-1.08   .002  
Sex, male   1.39   1.18-1.65   .001  
% marrow blasts   1.06  1.01-1.11   .012  
Age     .001  
70-79 y   1.23  1.04-1.47   
80 y or older   2.04  1.37-3.06   
Cytogenetics     <.001  
Complex ≥5   4.49  2.85-7.06   
Rare aberrations   2.23  1.31-3.79   
Fewer than 5 non-CBF AML, nonrare aberrations
 
1.52
 
1.03-2.25
 

 

OR indicates odds ratio for complete remission; HR, hazard ratio of relapse and/or death for DFS and OS; and WBC, white blood cell count.

*

OR/HR for a change in WBC of 20 × 109/L.

OR/HR are relative to age 60 to 69 years.

OR relative to complex karyotype ≥ 3.

§

HR relative to all other karyotypes.

HR for an increase in bone marrow blasts of 10%.

HR relative to CBF AML group.

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