Table 4.

Significant prognostic cytogenetic risk groups identified by tree analysis for CR, DFS, and OS


Cytogenetic risk groups

No.

Outcome, % (95% CI)*
Complete remission   
Complex ≥3   122   25 (17-32)  
Rare aberrations   33   30 (15-46)  
Noncomplex ≥3, nonrare aberrations   480   56 (51-60)  
Disease-free survival   
Complex >5   22   0  
Fewer than 5 aberrations   286   9.1 (6.1-12.8)  
Overall survival   
Complex ≥5   94   0  
CBF AML   31   19.4 (7.9-34.6)  
Rare aberrations   33   0  
Fewer than 5 non-CBF AML, nonrare aberrations
 
477
 
7.5 (5.4-10.1)
 

Cytogenetic risk groups

No.

Outcome, % (95% CI)*
Complete remission   
Complex ≥3   122   25 (17-32)  
Rare aberrations   33   30 (15-46)  
Noncomplex ≥3, nonrare aberrations   480   56 (51-60)  
Disease-free survival   
Complex >5   22   0  
Fewer than 5 aberrations   286   9.1 (6.1-12.8)  
Overall survival   
Complex ≥5   94   0  
CBF AML   31   19.4 (7.9-34.6)  
Rare aberrations   33   0  
Fewer than 5 non-CBF AML, nonrare aberrations
 
477
 
7.5 (5.4-10.1)
 
*

The outcome data show the complete remission rate, the 5-year DFS, and the 5-year OS.

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