Table 1. Retroviral integration sites in... | American Society of Hematology

Table 1.

Retroviral integration sites in VP16-Meis and VP16-MeisΔ334 leukemias

	Hox expression levels, no. of copies
Genotype, mouse ID no.	Hoxa5	Hoxa7	Hoxa9	Integration (distance to Hox locus, Mb)
*VP16-Meis1*
20	460	880	100 000	3qF1
45	8979	50 000	1 330	4qD3, 5qF, 5qG2
VP16-MeisΔ334
22	1200	2 100	30 000	5qG2, 6qC1 (+15*)
33	220	6 900	2 980	6qG1 (+85), 4qE2, 1qB, 6qB3 (0†), 8qE1, 6qC1 (+15*), 11qB3 (+41)
35	350	120	400 000	3qE1, 8qE1, 1qC5, 6qC1 (+15*)
36	300	4 360	420	19qB, 10qC2, 11qB3 (-33), 4qE2, 11qA1 (-46)

	Hox expression levels, no. of copies
Genotype, mouse ID no.	Hoxa5	Hoxa7	Hoxa9	Integration (distance to Hox locus, Mb)
*VP16-Meis1*
20	460	880	100 000	3qF1
45	8979	50 000	1 330	4qD3, 5qF, 5qG2
VP16-MeisΔ334
22	1200	2 100	30 000	5qG2, 6qC1 (+15*)
33	220	6 900	2 980	6qG1 (+85), 4qE2, 1qB, 6qB3 (0†), 8qE1, 6qC1 (+15*), 11qB3 (+41)
35	350	120	400 000	3qE1, 8qE1, 1qC5, 6qC1 (+15*)
36	300	4 360	420	19qB, 10qC2, 11qB3 (-33), 4qE2, 11qA1 (-46)

+ and - refer to integration of provirus centromeric versus telomeric, respectively, from the Hox locus.

Identical RIS.

Integration at 2.1 kb downstream of Hoxa7 and 4.4 kb upstream of the Hoxa9 gene.