Table 1.

Inhibition of the kinase activity of human wild-type (WT) and mutant (D816V) KIT by dasatinib and imatinib

Kinase
IC50, nM
Dasatinib  
KIT(WT)   79  
KIT(D816V)   37  
Imatinib  
KIT(WT)   1 550  
KIT(D816V)
 		 > 10 000
 
Kinase
IC50, nM
Dasatinib  
KIT(WT)   79  
KIT(D816V)   37  
Imatinib  
KIT(WT)   1 550  
KIT(D816V)
 		 > 10 000
 
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