Table 2.

List of the top 20 genes identified in a matched-pair analysis differentially expressed between initial diagnosis and relapse (32 precursor B-ALL)

Rank
Time of high expression
FDR, %
P
Affymetrix ID
Symbol
Gene title
Reported function
1   Diagnosis   0.66   .000001   204642_at  EDG1  Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1   Cell adhesion, signal transduction  
2   Diagnosis   0.66   .000002   203795_s_at  BCL7A  B-cell CLL/lymphoma 7A   Putative tumor suppressor  
3   Relapse   0.97   .000003   203554_x_at  PTTG1  Pituitary tumor-transforming 1   DNA replication and repair; cell cycle  
4   Relapse   2.11   .00001   200834_s_at  RPS21  Ribosomal protein S21   Protein biosynthesis  
5   Relapse   2.11   .000016   200763_s_at  RPLP1  Ribosomal protein, large, P1   Protein biosynthesis  
6   Relapse   2.11   .000017   213166_x_at  FLJ14346  Hypothetical protein FLJ14346  Unknown  
7   Relapse   2.11   .000019   201757_at  NDUFS5  NADH-coenzyme Q reductase   Mitochondrial electron transport  
8   Relapse   2.11   .000021   200980_s_at  PDHA1  Pyruvate dehydrogenase (lipoamide) alpha 1   Glycolysis; protein polyubiquitination  
9   Diagnosis   2.11   .000023   203796_s_at  BCL7A  B-cell CLL/lymphoma 7A   Putative tumor suppressor  
10   Relapse   2.11   .000026   203989_x_at  F2R  Coagulation factor II (thrombin) receptor   Cell-cycle regulation, apoptosis  
11   Relapse   2.11   .000029   200061_s_at  RPS24  Ribosomal protein S24   Protein biosynthesis  
12   Relapse   2.11   .000029   201001_s_at  UBE2V1  Ubiquitin-conjugating enzyme E2 variant 1   Cell-cycle progression; DNA repair  
13   Relapse   2.11   .000031   212834_at  DDX52  DEAD (Asp-Glu-Ala-Asp) box polypeptide 52   Nucleic acid binding, helicase activity  
14   Diagnosis   2.12   .000034   213875_x_at  C6orf62  Chromosome 6 open reading frame 62   Unknown  
15   Diagnosis   2.51   .000044   208892_s_at  DUSP6  Dual-specificity phosphatase 6   Cell-cycle progression; DNA repair  
16   Diagnosis   2.51   .000048   206864_s_at  HRK  Harakiri, BCL2 interacting protein (contains only BH3 domain)   Induction of apoptosis  
17   Relapse   2.51   .000049   217491_x_at  COX7C  Cytochrome c oxidase subunit VIIc   Generation of precursor metabolites and energy  
18   Relapse   2.51   .000052   201002_s_at  UBE2V1  Ubiquitin-conjugating enzyme E2 variant   Cell-cycle progression; DNA repair  
19   Relapse   2.51   .000054   202279_at  C14orf2  Chromosome 14 open reading frame 2   Unknown  
20
 		 Diagnosis
 		 2.51
 		 .000057
 		 49485_at
 		PRDM4
 		 PR domain containing 4
 		 Transcription regulation
 
Rank
Time of high expression
FDR, %
P
Affymetrix ID
Symbol
Gene title
Reported function
1   Diagnosis   0.66   .000001   204642_at  EDG1  Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1   Cell adhesion, signal transduction  
2   Diagnosis   0.66   .000002   203795_s_at  BCL7A  B-cell CLL/lymphoma 7A   Putative tumor suppressor  
3   Relapse   0.97   .000003   203554_x_at  PTTG1  Pituitary tumor-transforming 1   DNA replication and repair; cell cycle  
4   Relapse   2.11   .00001   200834_s_at  RPS21  Ribosomal protein S21   Protein biosynthesis  
5   Relapse   2.11   .000016   200763_s_at  RPLP1  Ribosomal protein, large, P1   Protein biosynthesis  
6   Relapse   2.11   .000017   213166_x_at  FLJ14346  Hypothetical protein FLJ14346  Unknown  
7   Relapse   2.11   .000019   201757_at  NDUFS5  NADH-coenzyme Q reductase   Mitochondrial electron transport  
8   Relapse   2.11   .000021   200980_s_at  PDHA1  Pyruvate dehydrogenase (lipoamide) alpha 1   Glycolysis; protein polyubiquitination  
9   Diagnosis   2.11   .000023   203796_s_at  BCL7A  B-cell CLL/lymphoma 7A   Putative tumor suppressor  
10   Relapse   2.11   .000026   203989_x_at  F2R  Coagulation factor II (thrombin) receptor   Cell-cycle regulation, apoptosis  
11   Relapse   2.11   .000029   200061_s_at  RPS24  Ribosomal protein S24   Protein biosynthesis  
12   Relapse   2.11   .000029   201001_s_at  UBE2V1  Ubiquitin-conjugating enzyme E2 variant 1   Cell-cycle progression; DNA repair  
13   Relapse   2.11   .000031   212834_at  DDX52  DEAD (Asp-Glu-Ala-Asp) box polypeptide 52   Nucleic acid binding, helicase activity  
14   Diagnosis   2.12   .000034   213875_x_at  C6orf62  Chromosome 6 open reading frame 62   Unknown  
15   Diagnosis   2.51   .000044   208892_s_at  DUSP6  Dual-specificity phosphatase 6   Cell-cycle progression; DNA repair  
16   Diagnosis   2.51   .000048   206864_s_at  HRK  Harakiri, BCL2 interacting protein (contains only BH3 domain)   Induction of apoptosis  
17   Relapse   2.51   .000049   217491_x_at  COX7C  Cytochrome c oxidase subunit VIIc   Generation of precursor metabolites and energy  
18   Relapse   2.51   .000052   201002_s_at  UBE2V1  Ubiquitin-conjugating enzyme E2 variant   Cell-cycle progression; DNA repair  
19   Relapse   2.51   .000054   202279_at  C14orf2  Chromosome 14 open reading frame 2   Unknown  
20
 		 Diagnosis
 		 2.51
 		 .000057
 		 49485_at
 		PRDM4
 		 PR domain containing 4
 		 Transcription regulation
 
View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal