Chemokine receptors, integrin molecules on Treg cells, and Treg-cell trafficking
Molecules . | Migration sites . | Functional outcome . | Sources . |
---|---|---|---|
CCR2 | Mouse joint tissues with collagen-induced arthritis | Reduced inflammation | Bruhl et al26 |
CCR4 | Human ovarian tumor | Reduced TAA-specific T-cell immunity | Curiel et al17 |
CCR4 | Mouse cardiac allograft | Prevention of graft rejection | Lee et al27 |
CCR5 | Mouse LNs and GVHD targeted multiple organs | Prevention of graft rejection | Wysocki et al28 |
CCR7 | Mouse lymphoid organs, T-cell zones | Suppression of T-cell priming | Lim et al25 |
CXCR4 | Mouse and human bone marrow | Bone marrow may function as a reservoir for Treg cells | Zou et al16 |
CD62L | Mouse lymph nodes | Prevention of autoimmunity and GVHD | Szanya et al,20 Ermann et al,21 Taylor et al,22 Ochando et al23 |
CD62P,E | Mouse inflammatory skin | Reduced UV-induced skin inflammation | Schwarz et al,29 Siegmund et al30 |
CD103 | Leishmania major—infected mouse skin | Induction of chronic infection | Suffia et al,31 Lehmann et al,32 Huehn et al,33 Sugiyama et al34 |
Molecules . | Migration sites . | Functional outcome . | Sources . |
---|---|---|---|
CCR2 | Mouse joint tissues with collagen-induced arthritis | Reduced inflammation | Bruhl et al26 |
CCR4 | Human ovarian tumor | Reduced TAA-specific T-cell immunity | Curiel et al17 |
CCR4 | Mouse cardiac allograft | Prevention of graft rejection | Lee et al27 |
CCR5 | Mouse LNs and GVHD targeted multiple organs | Prevention of graft rejection | Wysocki et al28 |
CCR7 | Mouse lymphoid organs, T-cell zones | Suppression of T-cell priming | Lim et al25 |
CXCR4 | Mouse and human bone marrow | Bone marrow may function as a reservoir for Treg cells | Zou et al16 |
CD62L | Mouse lymph nodes | Prevention of autoimmunity and GVHD | Szanya et al,20 Ermann et al,21 Taylor et al,22 Ochando et al23 |
CD62P,E | Mouse inflammatory skin | Reduced UV-induced skin inflammation | Schwarz et al,29 Siegmund et al30 |
CD103 | Leishmania major—infected mouse skin | Induction of chronic infection | Suffia et al,31 Lehmann et al,32 Huehn et al,33 Sugiyama et al34 |
LNs indicates lymph nodes; TAA, tumor-associated antigen; and GVHD, graft-versus-host disease.