Table 1.

Chemokine receptors, integrin molecules on Treg cells, and Treg-cell trafficking


Molecules

Migration sites

Functional outcome

Sources
CCR2   Mouse joint tissues with collagen-induced arthritis   Reduced inflammation   Bruhl et al26  
CCR4   Human ovarian tumor   Reduced TAA-specific T-cell immunity   Curiel et al17  
CCR4   Mouse cardiac allograft   Prevention of graft rejection   Lee et al27  
CCR5   Mouse LNs and GVHD targeted multiple organs   Prevention of graft rejection   Wysocki et al28  
CCR7   Mouse lymphoid organs, T-cell zones   Suppression of T-cell priming   Lim et al25  
CXCR4   Mouse and human bone marrow   Bone marrow may function as a reservoir for Treg cells   Zou et al16  
CD62L   Mouse lymph nodes   Prevention of autoimmunity and GVHD   Szanya et al,20  Ermann et al,21  Taylor et al,22  Ochando et al23  
CD62P,E   Mouse inflammatory skin   Reduced UV-induced skin inflammation   Schwarz et al,29  Siegmund et al30  
CD103
 
Leishmania major—infected mouse skin
 
Induction of chronic infection
 
Suffia et al,31  Lehmann et al,32  Huehn et al,33  Sugiyama et al34 
 

Molecules

Migration sites

Functional outcome

Sources
CCR2   Mouse joint tissues with collagen-induced arthritis   Reduced inflammation   Bruhl et al26  
CCR4   Human ovarian tumor   Reduced TAA-specific T-cell immunity   Curiel et al17  
CCR4   Mouse cardiac allograft   Prevention of graft rejection   Lee et al27  
CCR5   Mouse LNs and GVHD targeted multiple organs   Prevention of graft rejection   Wysocki et al28  
CCR7   Mouse lymphoid organs, T-cell zones   Suppression of T-cell priming   Lim et al25  
CXCR4   Mouse and human bone marrow   Bone marrow may function as a reservoir for Treg cells   Zou et al16  
CD62L   Mouse lymph nodes   Prevention of autoimmunity and GVHD   Szanya et al,20  Ermann et al,21  Taylor et al,22  Ochando et al23  
CD62P,E   Mouse inflammatory skin   Reduced UV-induced skin inflammation   Schwarz et al,29  Siegmund et al30  
CD103
 
Leishmania major—infected mouse skin
 
Induction of chronic infection
 
Suffia et al,31  Lehmann et al,32  Huehn et al,33  Sugiyama et al34 
 

LNs indicates lymph nodes; TAA, tumor-associated antigen; and GVHD, graft-versus-host disease.