Change in PT and PTT adjusted for FFP dose and patient weight 1 hour after first transfusion
. | Mean dose-adjusted change ± SD, sec/mL/kg . | P* . | Treatment difference of means . | 95% CI† . |
|---|---|---|---|---|
| Efficacy-evaluable population | ||||
| PT | ||||
| Test; n = 58 | 0.31 ± 0.60 | .676 | –0.04 | –0.25, 0.16 |
| Control; n = 58 | 0.35 ± 0.52 | — | — | — |
| PTT | ||||
| Test; n = 56 | 0.32 ± 0.75 | .398 | 0.69 | –0.91, 2.29 |
| Control; n = 55 | –0.37 ± 6.01 | — | — | — |
| OLT population | ||||
| PT | ||||
| Test; n = 22 | 0.02 ± 0.13 | .188 | –0.10 | –0.25, 0.05 |
| Control; n = 26 | 0.12 ± 0.36 | — | — | — |
| PTT | ||||
| Test; n = 22 | –0.03 ± 0.36 | .237 | –0.31 | –0.81, 0.20 |
| Control; n = 25 | 0.28 ± 1.22 | — | — | — |
| Non-OLT population | ||||
| PT | ||||
| Test; n = 36 | 0.49 ± 0.71 | .717 | –0.06 | –0.36, 0.25 |
| Control; n = 32 | 0.54 ± 0.56 | — | — | — |
| PTT | ||||
| Test; n = 34 | 0.54 ± 0.85 | .329 | 1.46 | –1.45, 4.37 |
| Control; n = 30 | –0.92 ± 8.08 | — | — | — |
. | Mean dose-adjusted change ± SD, sec/mL/kg . | P* . | Treatment difference of means . | 95% CI† . |
|---|---|---|---|---|
| Efficacy-evaluable population | ||||
| PT | ||||
| Test; n = 58 | 0.31 ± 0.60 | .676 | –0.04 | –0.25, 0.16 |
| Control; n = 58 | 0.35 ± 0.52 | — | — | — |
| PTT | ||||
| Test; n = 56 | 0.32 ± 0.75 | .398 | 0.69 | –0.91, 2.29 |
| Control; n = 55 | –0.37 ± 6.01 | — | — | — |
| OLT population | ||||
| PT | ||||
| Test; n = 22 | 0.02 ± 0.13 | .188 | –0.10 | –0.25, 0.05 |
| Control; n = 26 | 0.12 ± 0.36 | — | — | — |
| PTT | ||||
| Test; n = 22 | –0.03 ± 0.36 | .237 | –0.31 | –0.81, 0.20 |
| Control; n = 25 | 0.28 ± 1.22 | — | — | — |
| Non-OLT population | ||||
| PT | ||||
| Test; n = 36 | 0.49 ± 0.71 | .717 | –0.06 | –0.36, 0.25 |
| Control; n = 32 | 0.54 ± 0.56 | — | — | — |
| PTT | ||||
| Test; n = 34 | 0.54 ± 0.85 | .329 | 1.46 | –1.45, 4.37 |
| Control; n = 30 | –0.92 ± 8.08 | — | — | — |