Characteristics of fusion proteins associated with ALK-positive ALCL
Genetic aberration . | Frequency, % . | Fusion protein connected with TK domain of ALK 2p23 . | Size of fusion protein, kDa . | Staining pattern . |
|---|---|---|---|---|
| t(2;5)(p23;q35) | 73 | NPM | 80 | Cytoplasmic and nuclear |
| t(1;2)(q21;p23) | 18 | TPM3 | 104 | Cytoplasmic and nuclear |
| t(2;3)(p23;q21) | 3 | TFG | 97 | Cytoplasmic |
| t(2;22)(p23;q11) | 3 | CLTCL | 250 | Granular cytoplasmic |
| inv(2)(p23;q35) | 3 | ATIC | 96 | Cytoplasmic |
Genetic aberration . | Frequency, % . | Fusion protein connected with TK domain of ALK 2p23 . | Size of fusion protein, kDa . | Staining pattern . |
|---|---|---|---|---|
| t(2;5)(p23;q35) | 73 | NPM | 80 | Cytoplasmic and nuclear |
| t(1;2)(q21;p23) | 18 | TPM3 | 104 | Cytoplasmic and nuclear |
| t(2;3)(p23;q21) | 3 | TFG | 97 | Cytoplasmic |
| t(2;22)(p23;q11) | 3 | CLTCL | 250 | Granular cytoplasmic |
| inv(2)(p23;q35) | 3 | ATIC | 96 | Cytoplasmic |
TK indicates tyrosine kinase; ALK, anaplastic lymphoma kinase; ALCL, anaplastic large cell lymphoma; NPM, nucleophosim gene; TPM3, nonmuscle tropomyosin; TFG, tropomyosin receptor kinase-fused gene; CLTCL, clathrin heavy polypeptide-like gene; ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase; inv, inversion.74