Association between Th1/Th2 cytokine polymorphisms and non-Hodgkin lymphoma (NHL)
. | All NHL . | . | . | . | B-cell lymphoma . | . | . | T-cell lymphoma . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene name, SNP database ID (nucleotide change) . | No. of controls (%) . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | |||||||
| IL4 rs2243248 (-1098T>G) | |||||||||||||||||
| TT | 508 (88) | 411 (83) | 1.0 | — | 334 (85) | 1.0 | — | 22 (65) | 1.0 | — | |||||||
| GT or GG | 70 (12) | 82 (17) | 1.49 (1.05-2.11) | .026 | 59 (15) | 1.33 (0.91-1.95) | .14 | 12 (35) | 3.84 (1.79-8.22) | <.001 | |||||||
| NA | 3 | 6 | — | — | 3 | — | — | 3 | — | — | |||||||
| ND | 3 | 1 | — | — | 1 | — | — | 0 | — | — | |||||||
| IL4R rs2107356 (-28120C>T) | |||||||||||||||||
| CC | 200 (36) | 150 (32) | 1.0 | — | 124 (34) | 1.0 | — | 7 (20) | 1.0 | — | |||||||
| CT | 258 (47) | 249 (54) | 1.30 (0.98-1.71) | .069 | 190 (51) | 1.17 (0.87-1.58) | .30 | 22 (63) | 2.71 (1.09-6.75) | .032 | |||||||
| TT | 95 (17) | 65 (14) | 0.89 (0.61-1.31) | .56 | 55 (15) | 0.89 (0.60-1.34) | .59 | 6 (17) | 2.06 (0.65-6.56) | .22 | |||||||
| CT or TT | 353 (64) | 314 (68) | 1.19 (0.91-1.55) | .21 | 245 (66) | 1.10 (0.83-1.45) | .52 | 28 (80) | 2.55 (1.04-6.21) | .04 | |||||||
| Trend | — | — | — | .96 | — | — | .87 | — | — | .14 | |||||||
| NA | 14 | 16 | — | — | 13 | — | — | 1 | — | — | |||||||
| ND | 6 | 7 | — | — | 7 | — | — | 0 | — | — | |||||||
| IL5 rs2069812 (-745C>T) | |||||||||||||||||
| CC | 273 (49) | 219 (46) | 1.0 | — | 172 (45) | 1.0 | — | 18 (51) | 1.0 | — | |||||||
| CT | 238 (42) | 199 (41) | 1.05 (0.81-1.37) | .70 | 160 (42) | 1.08 (0.82-1.43) | .58 | 13 (37) | 0.83 (0.4-1.73) | .62 | |||||||
| TT | 51 (9) | 62 (13) | 1.63 (1.04-2.54) | .032 | 50 (13) | 1.76 (1.11-2.81) | .017 | 4 (11) | NC | — | |||||||
| CT or TT | 289 (51) | 261 (54) | 1.14 (0.89-1.46) | .31 | 210 (55) | 1.18 (0.91-1.54) | .22 | 17 (49) | 0.81 (0.4-1.65) | .56 | |||||||
| Trend | — | — | — | .08 | — | — | .046 | — | — | — | |||||||
| NA | 10 | 5 | — | — | 4 | — | — | 1 | — | — | |||||||
| ND | 1 | 4 | — | — | 4 | — | — | 0 | — | — | |||||||
| IL6 rs1800795 (-174 G>C) | |||||||||||||||||
| GG | 241 (41) | 211 (41) | 1.0 | — | 160 (39) | 1.0 | — | 23 (61) | 1.0 | — | |||||||
| CG | 264 (45) | 231 (45) | 0.97 (0.75-1.26) | .83 | 182 (45) | 0.99 (0.75-1.31) | .95 | 14 (37) | 0.56 (0.28-1.13) | .11 | |||||||
| CC | 85 (14) | 68 (13) | 0.90 (0.62-1.31) | .58 | 64 (16) | 1.09 (0.74-1.61) | .65 | 1 (3) | NC | — | |||||||
| CG or CC | 349 (59) | 299 (59) | 0.96 (0.75-1.22) | .71 | 246 (61) | 1.02 (0.78-1.32) | .91 | 15 (39) | 0.46 (0.23-0.92) | .027 | |||||||
| Trend | — | — | — | .60 | — | — | .73 | — | — | — | |||||||
| NA | 3 | 4 | — | — | 3 | — | — | 1 | — | — | |||||||
| ND | 4 | 4 | — | — | 2 | — | — | 0 | — | — | |||||||
| IL6 rs1800797 (-598G>A) | |||||||||||||||||
| GG | 233 (41) | 212 (43) | 1.0 | — | 159 (41) | 1.0 | — | 24 (65) | 1.0 | — | |||||||
| AG | 254 (44) | 217 (44) | 0.92 (0.71-1.20) | .54 | 171 (44) | 0.95 (0.71-1.26) | .70 | 12 (32) | 0.47 (0.23-0.97) | .041 | |||||||
| AA | 84 (15) | 64 (13) | 0.82 (0.56-1.19) | .30 | 61 (16) | 1.01 (0.69-1.50) | .95 | 1 (3) | NC | — | |||||||
| AG or AA | 338 (59) | 281 (57) | 0.89 (0.70-1.15) | .38 | 232 (59) | 0.96 (0.74-1.26) | .78 | 13 (35) | 0.38 (0.19-0.78) | .008 | |||||||
| Trend | — | — | — | .29 | — | — | .94 | — | — | — | |||||||
| NA | 18 | 14 | — | — | 10 | — | — | 2 | — | — | |||||||
| ND | 8 | 9 | — | — | 9 | — | — | 0 | — | — | |||||||
| IL10 rs1800871 (-819C>T) | |||||||||||||||||
| CC | 329 (57) | 274 (56) | 1.0 | — | 212 (54) | 1.0 | — | 24 (67) | 1.0 | — | |||||||
| CT | 211 (37) | 191 (39) | 1.10 (0.85-1.42) | .46 | 162 (41) | 1.22 (0.93-1.60) | .15 | 9 (25) | 0.56 (0.25-1.25) | .16 | |||||||
| TT | 34 (6) | 26 (5) | 0.97 (0.56-1.67) | .92 | 17 (4) | 0.84 (0.46-1.56) | .59 | 3 (8) | NC | — | |||||||
| CT or TT | 245 (43) | 217 (44) | 1.08 (0.85-1.39) | .52 | 179 (46) | 1.17 (0.90-1.52) | .24 | 12 (33) | 0.64 (0.31-1.32) | .22 | |||||||
| Trend | — | — | — | .66 | — | — | .50 | — | — | — | |||||||
| NA | 4 | 4 | — | — | 3 | — | — | 1 | — | — | |||||||
| ND | 3 | 3 | — | — | 2 | — | — | 0 | — | — | |||||||
| IL10 rs1800872 (-592C>A) | |||||||||||||||||
| CC | 331 (59) | 273 (57) | 1.0 | — | 213 (55) | 1.0 | — | 24 (65) | 1.0 | — | |||||||
| AC | 189 (34) | 174 (36) | 1.14 (0.88-1.48) | .33 | 146 (38) | 1.24 (0.94-1.64) | .13 | 9 (24) | 0.62 (0.28-1.38) | .24 | |||||||
| AA | 43 (8) | 35 (7) | 1.04 (0.65-1.69) | .86 | 25 (7) | 0.97 (0.57-1.65) | .92 | 4 (11) | NC | — | |||||||
| AC or AA | 232 (41) | 209 (43) | 1.12 (0.88-1.44) | .36 | 171 (45) | 1.19 (0.92-1.56) | .19 | 13 (35) | 0.73 (0.36-1.48) | .38 | |||||||
| Trend | — | — | — | .48 | — | — | .39 | — | — | — | |||||||
| NA | 5 | 1 | — | — | 1 | — | — | 0 | — | — | |||||||
| ND | 13 | 13 | — | — | 10 | — | — | 0 | — | — | |||||||
| IL10 rs1800896 (-1082A>G) | |||||||||||||||||
| AA | 184 (31) | 137 (27) | 1.0 | — | 103 (25) | 1.0 | — | 11 (29) | 1.0 | — | |||||||
| AG | 305 (52) | 260 (51) | 1.14 (0.86-1.51) | .35 | 209 (51) | 1.23 (0.91-1.66) | .18 | 20 (53) | 1.07 (0.50-2.29) | .86 | |||||||
| GG | 98 (17) | 113 (22) | 1.53 (1.08-2.17) | .018 | 94 (23) | 1.68 (1.15-2.44) | .007 | 7 (18) | 1.22 (0.46-3.27) | .69 | |||||||
| AG or GG | 403 (69) | 373 (73) | 1.24 (0.95-1.61) | .12 | 303 (75) | 1.34 (1.01-1.78) | .045 | 27 (71) | 1.11 (0.54-2.28) | .79 | |||||||
| Trend | — | — | — | .022 | — | — | .007 | — | — | .70 | |||||||
| NA | 2 | 1 | — | — | 0 | — | — | 1 | — | — | |||||||
| ND | 8 | 7 | — | — | 5 | — | — | 0 | — | — | |||||||
| IL10 rs1800890 (-3575T>A) | |||||||||||||||||
| TT | 261 (44) | 188 (37) | 1.0 | — | 145 (36) | 1.0 | — | 17 (45) | 1.0 | — | |||||||
| AT | 280 (47) | 244 (48) | 1.21 (0.94-1.56) | .15 | 197 (49) | 1.27 (0.96-1.67) | .09 | 16 (42) | 0.90 (0.44-1.82) | .76 | |||||||
| AA | 56 (9) | 78 (15) | 1.94 (1.31-2.87) | < .001 | 64 (16) | 2.05 (1.36-3.11) | < .001 | 5 (13) | 1.44 (0.50-4.10) | .50 | |||||||
| AT or AA | 336 (56) | 322 (63) | 1.33 (1.04-1.70) | .022 | 261 (64) | 1.40 (1.08-1.82) | .012 | 21 (55) | 0.98 (0.51-1.92) | .96 | |||||||
| Trend | — | — | — | .002 | — | — | < .001 | — | — | .73 | |||||||
| NA | 0 | 3 | — | — | 2 | — | — | 1 | — | — | |||||||
| ND | 0 | 3 | — | — | 2 | — | — | 0 | — | — | |||||||
. | All NHL . | . | . | . | B-cell lymphoma . | . | . | T-cell lymphoma . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene name, SNP database ID (nucleotide change) . | No. of controls (%) . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | |||||||
| IL4 rs2243248 (-1098T>G) | |||||||||||||||||
| TT | 508 (88) | 411 (83) | 1.0 | — | 334 (85) | 1.0 | — | 22 (65) | 1.0 | — | |||||||
| GT or GG | 70 (12) | 82 (17) | 1.49 (1.05-2.11) | .026 | 59 (15) | 1.33 (0.91-1.95) | .14 | 12 (35) | 3.84 (1.79-8.22) | <.001 | |||||||
| NA | 3 | 6 | — | — | 3 | — | — | 3 | — | — | |||||||
| ND | 3 | 1 | — | — | 1 | — | — | 0 | — | — | |||||||
| IL4R rs2107356 (-28120C>T) | |||||||||||||||||
| CC | 200 (36) | 150 (32) | 1.0 | — | 124 (34) | 1.0 | — | 7 (20) | 1.0 | — | |||||||
| CT | 258 (47) | 249 (54) | 1.30 (0.98-1.71) | .069 | 190 (51) | 1.17 (0.87-1.58) | .30 | 22 (63) | 2.71 (1.09-6.75) | .032 | |||||||
| TT | 95 (17) | 65 (14) | 0.89 (0.61-1.31) | .56 | 55 (15) | 0.89 (0.60-1.34) | .59 | 6 (17) | 2.06 (0.65-6.56) | .22 | |||||||
| CT or TT | 353 (64) | 314 (68) | 1.19 (0.91-1.55) | .21 | 245 (66) | 1.10 (0.83-1.45) | .52 | 28 (80) | 2.55 (1.04-6.21) | .04 | |||||||
| Trend | — | — | — | .96 | — | — | .87 | — | — | .14 | |||||||
| NA | 14 | 16 | — | — | 13 | — | — | 1 | — | — | |||||||
| ND | 6 | 7 | — | — | 7 | — | — | 0 | — | — | |||||||
| IL5 rs2069812 (-745C>T) | |||||||||||||||||
| CC | 273 (49) | 219 (46) | 1.0 | — | 172 (45) | 1.0 | — | 18 (51) | 1.0 | — | |||||||
| CT | 238 (42) | 199 (41) | 1.05 (0.81-1.37) | .70 | 160 (42) | 1.08 (0.82-1.43) | .58 | 13 (37) | 0.83 (0.4-1.73) | .62 | |||||||
| TT | 51 (9) | 62 (13) | 1.63 (1.04-2.54) | .032 | 50 (13) | 1.76 (1.11-2.81) | .017 | 4 (11) | NC | — | |||||||
| CT or TT | 289 (51) | 261 (54) | 1.14 (0.89-1.46) | .31 | 210 (55) | 1.18 (0.91-1.54) | .22 | 17 (49) | 0.81 (0.4-1.65) | .56 | |||||||
| Trend | — | — | — | .08 | — | — | .046 | — | — | — | |||||||
| NA | 10 | 5 | — | — | 4 | — | — | 1 | — | — | |||||||
| ND | 1 | 4 | — | — | 4 | — | — | 0 | — | — | |||||||
| IL6 rs1800795 (-174 G>C) | |||||||||||||||||
| GG | 241 (41) | 211 (41) | 1.0 | — | 160 (39) | 1.0 | — | 23 (61) | 1.0 | — | |||||||
| CG | 264 (45) | 231 (45) | 0.97 (0.75-1.26) | .83 | 182 (45) | 0.99 (0.75-1.31) | .95 | 14 (37) | 0.56 (0.28-1.13) | .11 | |||||||
| CC | 85 (14) | 68 (13) | 0.90 (0.62-1.31) | .58 | 64 (16) | 1.09 (0.74-1.61) | .65 | 1 (3) | NC | — | |||||||
| CG or CC | 349 (59) | 299 (59) | 0.96 (0.75-1.22) | .71 | 246 (61) | 1.02 (0.78-1.32) | .91 | 15 (39) | 0.46 (0.23-0.92) | .027 | |||||||
| Trend | — | — | — | .60 | — | — | .73 | — | — | — | |||||||
| NA | 3 | 4 | — | — | 3 | — | — | 1 | — | — | |||||||
| ND | 4 | 4 | — | — | 2 | — | — | 0 | — | — | |||||||
| IL6 rs1800797 (-598G>A) | |||||||||||||||||
| GG | 233 (41) | 212 (43) | 1.0 | — | 159 (41) | 1.0 | — | 24 (65) | 1.0 | — | |||||||
| AG | 254 (44) | 217 (44) | 0.92 (0.71-1.20) | .54 | 171 (44) | 0.95 (0.71-1.26) | .70 | 12 (32) | 0.47 (0.23-0.97) | .041 | |||||||
| AA | 84 (15) | 64 (13) | 0.82 (0.56-1.19) | .30 | 61 (16) | 1.01 (0.69-1.50) | .95 | 1 (3) | NC | — | |||||||
| AG or AA | 338 (59) | 281 (57) | 0.89 (0.70-1.15) | .38 | 232 (59) | 0.96 (0.74-1.26) | .78 | 13 (35) | 0.38 (0.19-0.78) | .008 | |||||||
| Trend | — | — | — | .29 | — | — | .94 | — | — | — | |||||||
| NA | 18 | 14 | — | — | 10 | — | — | 2 | — | — | |||||||
| ND | 8 | 9 | — | — | 9 | — | — | 0 | — | — | |||||||
| IL10 rs1800871 (-819C>T) | |||||||||||||||||
| CC | 329 (57) | 274 (56) | 1.0 | — | 212 (54) | 1.0 | — | 24 (67) | 1.0 | — | |||||||
| CT | 211 (37) | 191 (39) | 1.10 (0.85-1.42) | .46 | 162 (41) | 1.22 (0.93-1.60) | .15 | 9 (25) | 0.56 (0.25-1.25) | .16 | |||||||
| TT | 34 (6) | 26 (5) | 0.97 (0.56-1.67) | .92 | 17 (4) | 0.84 (0.46-1.56) | .59 | 3 (8) | NC | — | |||||||
| CT or TT | 245 (43) | 217 (44) | 1.08 (0.85-1.39) | .52 | 179 (46) | 1.17 (0.90-1.52) | .24 | 12 (33) | 0.64 (0.31-1.32) | .22 | |||||||
| Trend | — | — | — | .66 | — | — | .50 | — | — | — | |||||||
| NA | 4 | 4 | — | — | 3 | — | — | 1 | — | — | |||||||
| ND | 3 | 3 | — | — | 2 | — | — | 0 | — | — | |||||||
| IL10 rs1800872 (-592C>A) | |||||||||||||||||
| CC | 331 (59) | 273 (57) | 1.0 | — | 213 (55) | 1.0 | — | 24 (65) | 1.0 | — | |||||||
| AC | 189 (34) | 174 (36) | 1.14 (0.88-1.48) | .33 | 146 (38) | 1.24 (0.94-1.64) | .13 | 9 (24) | 0.62 (0.28-1.38) | .24 | |||||||
| AA | 43 (8) | 35 (7) | 1.04 (0.65-1.69) | .86 | 25 (7) | 0.97 (0.57-1.65) | .92 | 4 (11) | NC | — | |||||||
| AC or AA | 232 (41) | 209 (43) | 1.12 (0.88-1.44) | .36 | 171 (45) | 1.19 (0.92-1.56) | .19 | 13 (35) | 0.73 (0.36-1.48) | .38 | |||||||
| Trend | — | — | — | .48 | — | — | .39 | — | — | — | |||||||
| NA | 5 | 1 | — | — | 1 | — | — | 0 | — | — | |||||||
| ND | 13 | 13 | — | — | 10 | — | — | 0 | — | — | |||||||
| IL10 rs1800896 (-1082A>G) | |||||||||||||||||
| AA | 184 (31) | 137 (27) | 1.0 | — | 103 (25) | 1.0 | — | 11 (29) | 1.0 | — | |||||||
| AG | 305 (52) | 260 (51) | 1.14 (0.86-1.51) | .35 | 209 (51) | 1.23 (0.91-1.66) | .18 | 20 (53) | 1.07 (0.50-2.29) | .86 | |||||||
| GG | 98 (17) | 113 (22) | 1.53 (1.08-2.17) | .018 | 94 (23) | 1.68 (1.15-2.44) | .007 | 7 (18) | 1.22 (0.46-3.27) | .69 | |||||||
| AG or GG | 403 (69) | 373 (73) | 1.24 (0.95-1.61) | .12 | 303 (75) | 1.34 (1.01-1.78) | .045 | 27 (71) | 1.11 (0.54-2.28) | .79 | |||||||
| Trend | — | — | — | .022 | — | — | .007 | — | — | .70 | |||||||
| NA | 2 | 1 | — | — | 0 | — | — | 1 | — | — | |||||||
| ND | 8 | 7 | — | — | 5 | — | — | 0 | — | — | |||||||
| IL10 rs1800890 (-3575T>A) | |||||||||||||||||
| TT | 261 (44) | 188 (37) | 1.0 | — | 145 (36) | 1.0 | — | 17 (45) | 1.0 | — | |||||||
| AT | 280 (47) | 244 (48) | 1.21 (0.94-1.56) | .15 | 197 (49) | 1.27 (0.96-1.67) | .09 | 16 (42) | 0.90 (0.44-1.82) | .76 | |||||||
| AA | 56 (9) | 78 (15) | 1.94 (1.31-2.87) | < .001 | 64 (16) | 2.05 (1.36-3.11) | < .001 | 5 (13) | 1.44 (0.50-4.10) | .50 | |||||||
| AT or AA | 336 (56) | 322 (63) | 1.33 (1.04-1.70) | .022 | 261 (64) | 1.40 (1.08-1.82) | .012 | 21 (55) | 0.98 (0.51-1.92) | .96 | |||||||
| Trend | — | — | — | .002 | — | — | < .001 | — | — | .73 | |||||||
| NA | 0 | 3 | — | — | 2 | — | — | 1 | — | — | |||||||
| ND | 0 | 3 | — | — | 2 | — | — | 0 | — | — | |||||||
Values adjusted for age and race. Further adjustment of family history yielded similar results. P values less than .05 are italicized.
NA indicates no amplification observed; ND, amplification occurred but genotype could not be determined; NC, not calculated (for cells with fewer than 5 subjects); and —, not applicable.