Table 4.

Engraftment of CD33+ and CD33- fractions of AML in NOD/SCID mice

Sample no. and dose/mouse
No. mice with AML/no. mice injected
CD33+ fraction  
   1   
      1.0 × 106  2/5  
      3.0 × 106  0/2  
      6.0-10.0 × 106  6/8  
   2   
      1.0 × 106  2/3  
      6.0 × 106  2/2  
   3   
      4.0 × 105  1/3  
      1.0 × 106  3/3  
      1.0 × 107  2/2  
   4*  
      1.6 × 105  2/3  
      1.0 × 107  2/3  
   5*  
      5.9 × 105  0/2  
      8.4 × 106  1/1  
   6   
      1.5 × 106  2/3  
   7   
      5.0 × 106  0/1  
      2.0 × 106  0/4  
   8   
      2.4 × 106  2/3  
   9   
      3.8 × 106  3/3  
   10   
      2.1 × 106  0/3  
      7.0 × 106  1/1  
   11*†  
      3.5 × 105  2/4  
   12*†  
      2.0 × 106  4/4  
CD33- fraction  
   1   
      1.0 × 106  0/5  
      3.0 × 106  0/3  
   2   
      1.0 × 106  0/3  
   3   
      4.0 × 105  0/3  
   4*  
      1.6 × 105  0/3  
   5*  
      5.9 × 105  0/3  
   6   
      1.5 × 106  0/3  
   7   
      7.9 × 105  1/3  
      2.0 × 106  0/5  
   8   
      1.0 × 105  0/3  
   9   
      3.8 × 106  0/3  
   10   
      2.1 × 106  0/3  
   11*†  
      1.2 × 104  0/2  
   12*†  
      8.0 × 103
 		 0/2
 
Sample no. and dose/mouse
No. mice with AML/no. mice injected
CD33+ fraction  
   1   
      1.0 × 106  2/5  
      3.0 × 106  0/2  
      6.0-10.0 × 106  6/8  
   2   
      1.0 × 106  2/3  
      6.0 × 106  2/2  
   3   
      4.0 × 105  1/3  
      1.0 × 106  3/3  
      1.0 × 107  2/2  
   4*  
      1.6 × 105  2/3  
      1.0 × 107  2/3  
   5*  
      5.9 × 105  0/2  
      8.4 × 106  1/1  
   6   
      1.5 × 106  2/3  
   7   
      5.0 × 106  0/1  
      2.0 × 106  0/4  
   8   
      2.4 × 106  2/3  
   9   
      3.8 × 106  3/3  
   10   
      2.1 × 106  0/3  
      7.0 × 106  1/1  
   11*†  
      3.5 × 105  2/4  
   12*†  
      2.0 × 106  4/4  
CD33- fraction  
   1   
      1.0 × 106  0/5  
      3.0 × 106  0/3  
   2   
      1.0 × 106  0/3  
   3   
      4.0 × 105  0/3  
   4*  
      1.6 × 105  0/3  
   5*  
      5.9 × 105  0/3  
   6   
      1.5 × 106  0/3  
   7   
      7.9 × 105  1/3  
      2.0 × 106  0/5  
   8   
      1.0 × 105  0/3  
   9   
      3.8 × 106  0/3  
   10   
      2.1 × 106  0/3  
   11*†  
      1.2 × 104  0/2  
   12*†  
      8.0 × 103
 		 0/2
 
*

NOD/SCID-β2m-/- mice were used as hosts for these AML samples

†

Lin-CD34+CD38- cells from these samples were sorted into CD33+ and CD33- fractions

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