Relationship between the amino acid at position 252 in Src-family proteins and the ability of NS-187 to inhibit its phosphorylation
Family . | Kinase . | Amino acid 252 . | NS-187 inhibitory activity . |
|---|---|---|---|
| Abl | Abl | Gln | High |
| Src-A | Yes | Cys | Low |
| Src-A | Src | Cys | Low |
| Src-A | Fyn | Gln | High |
| Src-B | Lyn | Gln | High |
Family . | Kinase . | Amino acid 252 . | NS-187 inhibitory activity . |
|---|---|---|---|
| Abl | Abl | Gln | High |
| Src-A | Yes | Cys | Low |
| Src-A | Src | Cys | Low |
| Src-A | Fyn | Gln | High |
| Src-B | Lyn | Gln | High |