Table 1.

MSCV integrations in immortalized lines that fail to overexpress Evil or Prdm16

Cell line, gene
Protein family
Location and distance
Orientation of provirus
Mouse chromosome
Human chromosome
Accession no.
BM-6       
   Spata13  Rho GTPase   Intron 2   Same   14   ND   AK_122448  
   Ltbr  Lymphotoxin B receptor   3′, 5 kb   Inverse   6   12p13   U_29173  
   Cd47*  Integrin-associated protein   5′, 1.5 kb   Same   16   3q13.13   BY_110082  
   AK045932   ND   Intron 1   Inverse   4   ND   AK_045932  
   BY734350   ND   5′, 11 kb   Inverse   2   ND   BY_734350  
BM-15       
   A830007P12Rik   ATPase   Exon 2   Inverse   2   ND   AK_043559  
   Gnb11  G protein like   5′, 0.8 kb   Same   16   22q11.2   BC_024635  
   Mef2d*  Transcription factor   5′, 2 kb   Same   3   1q12-q23   BC_011070  
BM-40       
   BC006933   Transcription factor RAM2   Intron 1   Inverse   12   ND   BC_006933  
   6330406I15Rik   ND   Intron 3   Inverse   5   ND   AB_055406  
   Lbr  Lamin binding   5′, 17 kb   Same   1   1q42.1   AK_030606  
BM-46       
   Cbx2  Chromobox protein   5′, 0.5 kb   Inverse   11   17q25.3   X_62537  
   Notch2*  Surface receptor   Intron 2   Same   3   1p13-p11   D_32210  
   BE627640   ND   3′, 3 kb   Same   16   ND   BE_627640  
   4930405D01Rik   ND   Intron 2   Inverse   16   ND   AK_015093  
   Ndrg3  Signal transduction   5′, 0.5 kb   Same   2   20q11.21-q11.23   AB_033922  
   Supt4h*  Chromatin modeling   3′, 7 kb   Same   11   17q21-q23   BC_024391  
BM-50       
   Prkcq  Kinase   5′, 0.5 kb   Inverse   2   10p15   D_11091  
   Cd9  Surface receptor   Intron 1   Inverse   6   12p13.3   AF_202893  
   Rai1  ND   5′, 2 kb   Same   11   17p11.2   BC_049785  
   BU604361   ND   5′, 0.6 kb   Same   3   ND   BU_604361  
BM-70       
   Setbp1  SET regulation   Intron 1   Same   18   ND   AB_007897  
   Tax1bp1  Signal transduction   5′, 15 kb   Same   6   7p15   AK_004574  
   Pftk1
 		 Kinase
 		 Intron 1
 		 Same
 		 5
 		 ND
 		 AF_033655
 
Cell line, gene
Protein family
Location and distance
Orientation of provirus
Mouse chromosome
Human chromosome
Accession no.
BM-6       
   Spata13  Rho GTPase   Intron 2   Same   14   ND   AK_122448  
   Ltbr  Lymphotoxin B receptor   3′, 5 kb   Inverse   6   12p13   U_29173  
   Cd47*  Integrin-associated protein   5′, 1.5 kb   Same   16   3q13.13   BY_110082  
   AK045932   ND   Intron 1   Inverse   4   ND   AK_045932  
   BY734350   ND   5′, 11 kb   Inverse   2   ND   BY_734350  
BM-15       
   A830007P12Rik   ATPase   Exon 2   Inverse   2   ND   AK_043559  
   Gnb11  G protein like   5′, 0.8 kb   Same   16   22q11.2   BC_024635  
   Mef2d*  Transcription factor   5′, 2 kb   Same   3   1q12-q23   BC_011070  
BM-40       
   BC006933   Transcription factor RAM2   Intron 1   Inverse   12   ND   BC_006933  
   6330406I15Rik   ND   Intron 3   Inverse   5   ND   AB_055406  
   Lbr  Lamin binding   5′, 17 kb   Same   1   1q42.1   AK_030606  
BM-46       
   Cbx2  Chromobox protein   5′, 0.5 kb   Inverse   11   17q25.3   X_62537  
   Notch2*  Surface receptor   Intron 2   Same   3   1p13-p11   D_32210  
   BE627640   ND   3′, 3 kb   Same   16   ND   BE_627640  
   4930405D01Rik   ND   Intron 2   Inverse   16   ND   AK_015093  
   Ndrg3  Signal transduction   5′, 0.5 kb   Same   2   20q11.21-q11.23   AB_033922  
   Supt4h*  Chromatin modeling   3′, 7 kb   Same   11   17q21-q23   BC_024391  
BM-50       
   Prkcq  Kinase   5′, 0.5 kb   Inverse   2   10p15   D_11091  
   Cd9  Surface receptor   Intron 1   Inverse   6   12p13.3   AF_202893  
   Rai1  ND   5′, 2 kb   Same   11   17p11.2   BC_049785  
   BU604361   ND   5′, 0.6 kb   Same   3   ND   BU_604361  
BM-70       
   Setbp1  SET regulation   Intron 1   Same   18   ND   AB_007897  
   Tax1bp1  Signal transduction   5′, 15 kb   Same   6   7p15   AK_004574  
   Pftk1
 		 Kinase
 		 Intron 1
 		 Same
 		 5
 		 ND
 		 AF_033655
 

ND indicates not determined.

*

Genes that are known CISs for replication-competent murine leukemia viruses29 

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