Differences between disorders characterized by increased iron absorption and decreased iron recycling
Increased iron absorption . | Decreased iron recycling . |
|---|---|
| Early increased transferrin saturation | Reduced/normal transferrin saturation |
| Late increase of serum ferritin | Early increase of serum ferritin |
| Iron accumulation in hepatocytes | Iron accumulation in macrophages |
| Normal hemoglobin levels | Anemia, iron-deficient erythropoiesis |
| Autosomal recessive | Autosomal dominant* |
Increased iron absorption . | Decreased iron recycling . |
|---|---|
| Early increased transferrin saturation | Reduced/normal transferrin saturation |
| Late increase of serum ferritin | Early increase of serum ferritin |
| Iron accumulation in hepatocytes | Iron accumulation in macrophages |
| Normal hemoglobin levels | Anemia, iron-deficient erythropoiesis |
| Autosomal recessive | Autosomal dominant* |
Except aceruloplasminemia.