Table 5.

Gene expression OR4N5-interacting proteins in tumor-educated blood platelets of 6 cancers

Gene IDGene nameBreast carcinomaColorectal carcinomaGlioblastomaHepatobiliary carcinomaNSC lung carcinomaPancreatic adenocarcinoma
P valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FC
ENSG00000168398 BDKRB2 8.34E−06 −2.5 2.01E−10 −3.4 .017445 −1.3 .029873 −1.5 7.62E−05 −1.9 8.29E−14 −4.6 
ENSG00000170989 S1PR1 4.25E−16 −3 5.66E−23 −4.1 .000261 −1.6 1.33E−06 −2.7 1.29E−11 −2.8 6.49E−26 −4.3 
ENSG00000173578 XCR1 1.42E−10 −3.1 2.88E−12 −3.6 .001756 −1.4 .000563 −2 4.14E−07 −2.3 3.56E−15 −4 
ENSG00000179934 CCR8 9.95E−20 −5.1 2.56E−09 −3.5 6.89E−05 −2.2 .00036 −2.5 4.48E−11 −3.3 3.38E−10 −3.8 
ENSG00000182162 P2RY8 5.20E−21 −3.7 2.77E−31 −4.8 .067366 −0.8 1.80E−05 −2.2 1.85E−08 −2.3 1.98E−15 −3.6 
ENSG00000126266 FFAR1 2.97E−11 −4.3 9.82E−10 −3.9 .000244 −2.2 .001767 −2.5 7.43E−07 −2.7 1.85E−06 −3.4 
ENSG00000176136 MC5R 1.71E−09 −3.8 4.73E−13 −4.3 .004435 −1.6 .000332 −2.9 3.65E−06 −2.5 5.71E−08 −3.4 
ENSG00000078549 ADCYAP1R1 2.72E−17 −4.4 1.43E−07 −2.8 .00033 −1.8 .001806 −2 1.63E−06 −2.3 4.25E−08 −3.1 
ENSG00000130368 MAS1 4.58E−12 −3 2.72E−10 −2.9 1.92E−06 −2.1 .000103 −2.2 2.63E−11 −2.7 9.52E−11 −3.2 
ENSG00000134443 GRP 1.12E−05 −2.8 1.37E−06 −3 .004968 −1.7 .003538 −2.5 .000561 −1.9 2.46E−05 −2.8 
ENSG00000230164 MAS1LP1 .0016 −2.8 .00586 −2.4 .244462 −0.9 .05131 −2.1 .019567 −1.6 .004013 −2.6 
ENSG00000232168 P2RY10BP .088036 −1.8 .125546 −1.8 .159953 −1.2 .479725 −0.8 .066438 −1.6 .07665 −2.1 
ENSG00000179271 GADD45GIP1 .03062 −0.7 1.13E−06 −1.8 .009743 −1 .040748 −0.8 .002364 −1 5.01E−08 −1.8 
ENSG00000204687 MAS1L .085128 −1.9 .181923 −1.4 .408644 −0.7 .433884 −0.9 .943563 −0.1 .199627 −1.5 
ENSG00000185899 TAS2R60 .285055 −1 .315573 −1 .617987 −0.4 .684782 −0.4 .281859 0.8 .194325 −1.3 
ENSG00000261713 SSTR5-AS1 .093192 −1.7 .481641 −0.8 .862472 −0.1 .790265 −0.3 .969677 0 .301099 −1.1 
ENSG00000078589 P2RY10 .299781 −0.2 .07939 −0.4 .736213 0.1 .002469 −0.9 .002711 −0.8 .000308 −0.8 
ENSG00000130222 GADD45G .081734 0.9 .920215 0.1 .190908 −0.7 .006607 1.8 .014 1.1 .3605 −0.6 
ENSG00000162009 SSTR5 NA −0.4 .924947 −0.2 NA −0.2 NA −0.2 NA −0.2 NA −0.3 
Gene IDGene nameBreast carcinomaColorectal carcinomaGlioblastomaHepatobiliary carcinomaNSC lung carcinomaPancreatic adenocarcinoma
P valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FC
ENSG00000168398 BDKRB2 8.34E−06 −2.5 2.01E−10 −3.4 .017445 −1.3 .029873 −1.5 7.62E−05 −1.9 8.29E−14 −4.6 
ENSG00000170989 S1PR1 4.25E−16 −3 5.66E−23 −4.1 .000261 −1.6 1.33E−06 −2.7 1.29E−11 −2.8 6.49E−26 −4.3 
ENSG00000173578 XCR1 1.42E−10 −3.1 2.88E−12 −3.6 .001756 −1.4 .000563 −2 4.14E−07 −2.3 3.56E−15 −4 
ENSG00000179934 CCR8 9.95E−20 −5.1 2.56E−09 −3.5 6.89E−05 −2.2 .00036 −2.5 4.48E−11 −3.3 3.38E−10 −3.8 
ENSG00000182162 P2RY8 5.20E−21 −3.7 2.77E−31 −4.8 .067366 −0.8 1.80E−05 −2.2 1.85E−08 −2.3 1.98E−15 −3.6 
ENSG00000126266 FFAR1 2.97E−11 −4.3 9.82E−10 −3.9 .000244 −2.2 .001767 −2.5 7.43E−07 −2.7 1.85E−06 −3.4 
ENSG00000176136 MC5R 1.71E−09 −3.8 4.73E−13 −4.3 .004435 −1.6 .000332 −2.9 3.65E−06 −2.5 5.71E−08 −3.4 
ENSG00000078549 ADCYAP1R1 2.72E−17 −4.4 1.43E−07 −2.8 .00033 −1.8 .001806 −2 1.63E−06 −2.3 4.25E−08 −3.1 
ENSG00000130368 MAS1 4.58E−12 −3 2.72E−10 −2.9 1.92E−06 −2.1 .000103 −2.2 2.63E−11 −2.7 9.52E−11 −3.2 
ENSG00000134443 GRP 1.12E−05 −2.8 1.37E−06 −3 .004968 −1.7 .003538 −2.5 .000561 −1.9 2.46E−05 −2.8 
ENSG00000230164 MAS1LP1 .0016 −2.8 .00586 −2.4 .244462 −0.9 .05131 −2.1 .019567 −1.6 .004013 −2.6 
ENSG00000232168 P2RY10BP .088036 −1.8 .125546 −1.8 .159953 −1.2 .479725 −0.8 .066438 −1.6 .07665 −2.1 
ENSG00000179271 GADD45GIP1 .03062 −0.7 1.13E−06 −1.8 .009743 −1 .040748 −0.8 .002364 −1 5.01E−08 −1.8 
ENSG00000204687 MAS1L .085128 −1.9 .181923 −1.4 .408644 −0.7 .433884 −0.9 .943563 −0.1 .199627 −1.5 
ENSG00000185899 TAS2R60 .285055 −1 .315573 −1 .617987 −0.4 .684782 −0.4 .281859 0.8 .194325 −1.3 
ENSG00000261713 SSTR5-AS1 .093192 −1.7 .481641 −0.8 .862472 −0.1 .790265 −0.3 .969677 0 .301099 −1.1 
ENSG00000078589 P2RY10 .299781 −0.2 .07939 −0.4 .736213 0.1 .002469 −0.9 .002711 −0.8 .000308 −0.8 
ENSG00000130222 GADD45G .081734 0.9 .920215 0.1 .190908 −0.7 .006607 1.8 .014 1.1 .3605 −0.6 
ENSG00000162009 SSTR5 NA −0.4 .924947 −0.2 NA −0.2 NA −0.2 NA −0.2 NA −0.3 

Gene expression levels of non-OR proteins that interact with OR4N5 in tumor-educated blood platelets across 6 cancer types. The listed proteins are OR4N5-interacting non-ORs. Red text highlights the most downregulated proteins in each cancer type, with S1PR1, XCR1, CCR8, P2RY8, FFAR1, MC5R, ADCYAP1R1, and MAS1 being among the most significantly downregulated genes across all 6 cancer types.

FC, fold change; ID, identity; NA, Not Available; NSC, non-small cell.

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