Table 4.

Gene expression level of OR4N5-interacting ORs (STRINGS) in tumor-educated blood platelets of 6 cancers

Gene IDGene nameBreast carcinomaColorectal carcinomaGlioblastomaHepatobiliary carcinomaNSC lung carcinomaPancreatic adenocarcinoma
P valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FC
ENSG00000094661 OR1I1 3.27E−15 −5.1 2.63E−15 −5.1 .000447 −2.1 .002053 −2.5 .000197 −2.2 1.39E−12 −4.9 
ENSG00000188269 OR7A5 2.05E−14 −3.9 2.31E−14 −4 .000273 −1.8 .002215 −2 5.76E−08 −2.6 7.06E−12 −3.8 
ENSG00000187857 OR6C75 2.06E−14 −4.5 2.73E−12 −4.2 .017369 −1.3 3.20E−07 −4.5 .000246 −2.1 2.02E−05 −2.6 
ENSG00000205328 OR6C65 2.93E−12 −4.6 3.42E−08 −3.6 .000356 −2.2 .000828 −2.7 5.54E−10 −3.5 1.73E−09 −4.1 
ENSG00000177535 OR2B11 3.90E−10 −4.3 3.15E−09 −4 .000181 −2.4 .000527 −3 1.39E−07 −3.2 .00022 −2.5 
ENSG00000184166 OR1D2 2.30E−08 −3.9 .001177 −2.3 .022729 −1.4 .031772 −1.8 3.44E−06 −2.9 3.18E−07 −3.7 
ENSG00000141194 OR4D1 4.00E−08 −3.6 1.35E−11 −4.5 .000113 −2.2 .003561 −2.4 2.46E−09 −3.4 3.63E−06 −3.2 
ENSG00000124657 OR2B6 7.88E−07 1.1 1.46E−06 1 .806643 0.1 7.71E−06 1.6 .000992 0.7 4.73E−07 1.3 
ENSG00000171942 OR10H2 5.60E−05 −3 9.10E−05 −2.9 .024594 −1.5 .130867 −1.4 1.73E−05 −2.8 3.93E−05 −3.2 
ENSG00000196240 OR2T2 6.35E−05 −3 4.50E−05 −2.9 .002662 −2 .011559 −2.4 1.82E−05 −2.7 6.51E−05 −3 
ENSG00000183024 OR1G1 .00011 −2.9 2.67E−07 −3.6 .015671 −1.5 .136376 −1.3 3.30E−06 −2.7 7.50E−10 −4.3 
ENSG00000175143 OR2T1 .000151 −3.2 .000201 −3.2 .0039 −2.1 .146061 −1.5 .000469 −2.4 .000778 −3 
ENSG00000221989 OR2A2 .000586 −2.6 2.44E−05 −3.2 .000131 −2.6 .026129 −2 .0008 −2.1 1.22E−06 −3.6 
ENSG00000254834 OR5M10 .001344 −2.5 .000185 −2.7 .110938 −1.1 .050194 −1.8 .01517 −1.6 9.78E−07 −4 
ENSG00000172188 OR4C11 .004885 −2.2 .008672 −2 .742986 −0.2 .899352 −0.1 .005355 −1.8 .002925 −2.5 
ENSG00000237388 OR4A47 .21225 −1.5 .468567 −0.9 .347595 −0.9 NA −0.8 .922457 −0.1 .392475 −1.1 
ENSG00000198283 OR5B21 .21835 −1.5 .306278 −1.2 .535776 −0.6 NA −0.7 .489942 −0.6 .506153 −0.8 
ENSG00000280236 OR12D2 .240472 −1.3 .144644 −1.5 .094247 −1.5 .496986 −0.8 .043656 −1.8 .066428 −2.1 
ENSG00000197125 OR8B8 .40181 −1.1 .491146 −0.9 .619077 −0.5 NA −0.5 .748128 0.3 .609838 −0.7 
ENSG00000180016 OR1E1 .411894 −0.8 .241953 −1.3 .29586 −0.9 .662732 −0.5 .27676 −0.9 .459317 −0.8 
ENSG00000165202 OR1Q1 .48255 −0.7 .264031 −1.3 .726106 0.3 NA −0.5 .853721 −0.1 .312266 −1.1 
ENSG00000204700 OR2J2 NA −0.5 .896021 −0.3 NA 0.2 NA 0.2 .091244 1.5 NA −0.3 
Gene IDGene nameBreast carcinomaColorectal carcinomaGlioblastomaHepatobiliary carcinomaNSC lung carcinomaPancreatic adenocarcinoma
P valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FCP valuelog2FC
ENSG00000094661 OR1I1 3.27E−15 −5.1 2.63E−15 −5.1 .000447 −2.1 .002053 −2.5 .000197 −2.2 1.39E−12 −4.9 
ENSG00000188269 OR7A5 2.05E−14 −3.9 2.31E−14 −4 .000273 −1.8 .002215 −2 5.76E−08 −2.6 7.06E−12 −3.8 
ENSG00000187857 OR6C75 2.06E−14 −4.5 2.73E−12 −4.2 .017369 −1.3 3.20E−07 −4.5 .000246 −2.1 2.02E−05 −2.6 
ENSG00000205328 OR6C65 2.93E−12 −4.6 3.42E−08 −3.6 .000356 −2.2 .000828 −2.7 5.54E−10 −3.5 1.73E−09 −4.1 
ENSG00000177535 OR2B11 3.90E−10 −4.3 3.15E−09 −4 .000181 −2.4 .000527 −3 1.39E−07 −3.2 .00022 −2.5 
ENSG00000184166 OR1D2 2.30E−08 −3.9 .001177 −2.3 .022729 −1.4 .031772 −1.8 3.44E−06 −2.9 3.18E−07 −3.7 
ENSG00000141194 OR4D1 4.00E−08 −3.6 1.35E−11 −4.5 .000113 −2.2 .003561 −2.4 2.46E−09 −3.4 3.63E−06 −3.2 
ENSG00000124657 OR2B6 7.88E−07 1.1 1.46E−06 1 .806643 0.1 7.71E−06 1.6 .000992 0.7 4.73E−07 1.3 
ENSG00000171942 OR10H2 5.60E−05 −3 9.10E−05 −2.9 .024594 −1.5 .130867 −1.4 1.73E−05 −2.8 3.93E−05 −3.2 
ENSG00000196240 OR2T2 6.35E−05 −3 4.50E−05 −2.9 .002662 −2 .011559 −2.4 1.82E−05 −2.7 6.51E−05 −3 
ENSG00000183024 OR1G1 .00011 −2.9 2.67E−07 −3.6 .015671 −1.5 .136376 −1.3 3.30E−06 −2.7 7.50E−10 −4.3 
ENSG00000175143 OR2T1 .000151 −3.2 .000201 −3.2 .0039 −2.1 .146061 −1.5 .000469 −2.4 .000778 −3 
ENSG00000221989 OR2A2 .000586 −2.6 2.44E−05 −3.2 .000131 −2.6 .026129 −2 .0008 −2.1 1.22E−06 −3.6 
ENSG00000254834 OR5M10 .001344 −2.5 .000185 −2.7 .110938 −1.1 .050194 −1.8 .01517 −1.6 9.78E−07 −4 
ENSG00000172188 OR4C11 .004885 −2.2 .008672 −2 .742986 −0.2 .899352 −0.1 .005355 −1.8 .002925 −2.5 
ENSG00000237388 OR4A47 .21225 −1.5 .468567 −0.9 .347595 −0.9 NA −0.8 .922457 −0.1 .392475 −1.1 
ENSG00000198283 OR5B21 .21835 −1.5 .306278 −1.2 .535776 −0.6 NA −0.7 .489942 −0.6 .506153 −0.8 
ENSG00000280236 OR12D2 .240472 −1.3 .144644 −1.5 .094247 −1.5 .496986 −0.8 .043656 −1.8 .066428 −2.1 
ENSG00000197125 OR8B8 .40181 −1.1 .491146 −0.9 .619077 −0.5 NA −0.5 .748128 0.3 .609838 −0.7 
ENSG00000180016 OR1E1 .411894 −0.8 .241953 −1.3 .29586 −0.9 .662732 −0.5 .27676 −0.9 .459317 −0.8 
ENSG00000165202 OR1Q1 .48255 −0.7 .264031 −1.3 .726106 0.3 NA −0.5 .853721 −0.1 .312266 −1.1 
ENSG00000204700 OR2J2 NA −0.5 .896021 −0.3 NA 0.2 NA 0.2 .091244 1.5 NA −0.3 

Gene expression levels of OR4N5-interacting ORs in tumor-educated platelets across 6 cancer types. The listed ORs interact with OR4N5 according to STRING analysis. Yellow highlights indicate significant downregulation, whereas purple highlights indicate upregulation in all 6 cancer types.

FC, fold change; ID, identity; NSC, non-small cell; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins, refers to Protein-Protein Interaction Networks Functional Enrichment Analysis.

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