Table 4.

Response rates according to VEN schedule duration

Schedule (per 28-day cycle)Total VEN≤7 days VEN8-21 days VEN22-28 days VENP valueAdjusted P value
n99423126≤7 vs 22-28 days
CR 26.3% 9.5% 32.3% 46.2% .001  .002  
Composite CR+CRi/p 48.5% 47.6% 41.9% 57.7% .420 .394 
Months to best response, median 4.1 4.8 4.0 2.7 .025  .039  
6-month EFS 38.4% 26.2% 45.2% 50.0% .049  .087 
No unscheduled acute care week 1-12 29.3% 9.5% 38.7% 50.0% .001  .002  
Schedule (per 28-day cycle)Total VEN≤7 days VEN8-21 days VEN22-28 days VENP valueAdjusted P value
n99423126≤7 vs 22-28 days
CR 26.3% 9.5% 32.3% 46.2% .001  .002  
Composite CR+CRi/p 48.5% 47.6% 41.9% 57.7% .420 .394 
Months to best response, median 4.1 4.8 4.0 2.7 .025  .039  
6-month EFS 38.4% 26.2% 45.2% 50.0% .049  .087 
No unscheduled acute care week 1-12 29.3% 9.5% 38.7% 50.0% .001  .002  

CRi/p, CR with incomplete platelet count recovery.

P < .05; adjusted P value used multivariable regression for differences in key baseline characteristics; P values are obtained from logistic regression analysis, other than for months to best response, in which they are from Kaplan-Meier analysis (unadjusted) and multivariable Cox regression analysis (adjusted).

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