The genes comprising the LSC17 score and currently known functional associations
| Gene . | Function in LSCs . | Subtype association . | References . |
|---|---|---|---|
| DNMT3B | Methylation of stem cell–associated genes | Experiments performed in KMT2A::MLLT3, Myc-Bcl2 (mice) | 59 |
| ZBTB46∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| NYNRIN | Mitochondrial regulation in HSCs, no evidence of functional role associated with LSCs | No evidence of subtype association | 60 |
| ARHGAP22∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| LAPTM4B | No evidence of functional role associated with LSCs | FLT3-ITD/NPM1 | 61 |
| MMRN1 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| DPYSL3 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| KIAA0125 | No evidence of functional role associated with LSCs | RUNX1, inversely correlated with t(8;21) and t(15;17) | 62 |
| CDK6∗ | Drives growth and activation of HSCs and LSCs | t(8;21), CEBPA, inversely correlated with inv(16); experiments in BCR::ABL1 (mice) | 63,64 |
| CPXM1∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| SOCS2 | Associated with LSC number and growth/quiescence control | Experiments performed in KMT2A::MLLT3, FLT3-ITD/NPM1c | 65,66 |
| SMIM24∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| EMP1 | No evidence of functional role associated with LSCs | Inv(16) | 67 |
| NGFRAP1 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| CD34 | Widely used cell surface marker, limited evidence of functional role in HSCs, no evidence of functional role associated with LSCs | Inconsistent expression with FLT3-ITD/NPM1 | 4,68 |
| AKR1C3∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| GPR56 | Associated with intracellular signaling, affects engraftment in mice | EVI1-high; experiments carried out in HOX/MEIS (mice), FLT3-ITD/NPM1c | 69,70 |
| Gene . | Function in LSCs . | Subtype association . | References . |
|---|---|---|---|
| DNMT3B | Methylation of stem cell–associated genes | Experiments performed in KMT2A::MLLT3, Myc-Bcl2 (mice) | 59 |
| ZBTB46∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| NYNRIN | Mitochondrial regulation in HSCs, no evidence of functional role associated with LSCs | No evidence of subtype association | 60 |
| ARHGAP22∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| LAPTM4B | No evidence of functional role associated with LSCs | FLT3-ITD/NPM1 | 61 |
| MMRN1 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| DPYSL3 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| KIAA0125 | No evidence of functional role associated with LSCs | RUNX1, inversely correlated with t(8;21) and t(15;17) | 62 |
| CDK6∗ | Drives growth and activation of HSCs and LSCs | t(8;21), CEBPA, inversely correlated with inv(16); experiments in BCR::ABL1 (mice) | 63,64 |
| CPXM1∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| SOCS2 | Associated with LSC number and growth/quiescence control | Experiments performed in KMT2A::MLLT3, FLT3-ITD/NPM1c | 65,66 |
| SMIM24∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| EMP1 | No evidence of functional role associated with LSCs | Inv(16) | 67 |
| NGFRAP1 | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| CD34 | Widely used cell surface marker, limited evidence of functional role in HSCs, no evidence of functional role associated with LSCs | Inconsistent expression with FLT3-ITD/NPM1 | 4,68 |
| AKR1C3∗ | No evidence of functional role associated with LSCs | No evidence of subtype association | |
| GPR56 | Associated with intracellular signaling, affects engraftment in mice | EVI1-high; experiments carried out in HOX/MEIS (mice), FLT3-ITD/NPM1c | 69,70 |
∗Genes with a negative influence on the score.