Results of multivariate analysis of independent risk factors for AJBR in a cohort of males with severe hemophilia
| Characteristic . | Hemophilia A . | Hemophilia B . | ||
|---|---|---|---|---|
| AJBR difference . | P value . | AJBR difference . | P value . | |
| Treatment product | ||||
| Recombinant SHL | Ref | Ref | ||
| FVIII mimetics | −1.0037 | <.0001 | ||
| Plasma-derived | −0.2084 | .2808 | 0.8864 | .0064 |
| Recombinant EHL | −0.258 | .0037 | −0.0811 | .7122 |
| Missed doses | ||||
| <10% | Ref | Ref | ||
| 10%-20% | 0.6757 | <.0001 | 0.2881 | .1122 |
| 21%-50% | 0.6395 | <.0001 | 1.2397 | <.0001 |
| >50% | 0.638 | .0003 | −0.0503 | .9198 |
| Health insurance | ||||
| Commercial | Ref | Ref | ||
| Government | 0.3983 | .0001 | −0.0763 | .6805 |
| Other | 0.1835 | .2759 | 0.4594 | .1209 |
| Employment status | ||||
| Employed, full or part-time | Ref | Ref | ||
| Not employed, with disability | 0.5204 | .011 | 0.2546 | .5533 |
| Not employed, without disability | 0.2902 | .2057 | 0.9796 | .0386 |
| Educational level | ||||
| Preelementary | Ref | Ref | ||
| Primary/secondary | −0.3904 | .1125 | −0.7259 | .0243 |
| 4-y/advanced college degree | −0.4933 | .01 | 0.0722 | .8264 |
| High school/technical/some college | −0.0778 | .6239 | 0.0895 | .6784 |
| Age, y | ||||
| 2-9 | Ref | Ref | ||
| 10-19 | 0.3548 | .0131 | 0.7533 | .0015 |
| 20-44 | 1.0105 | <.0001 | 1.7186 | <.0001 |
| Region | ||||
| Northeast | Ref | Ref | ||
| Midwest | 0.3377 | .0067 | 0.7266 | .0039 |
| Southeast | 0.3335 | .0113 | 0.5389 | .04 |
| West | 0.4779 | .0049 | 0.6144 | .0441 |
| Characteristic . | Hemophilia A . | Hemophilia B . | ||
|---|---|---|---|---|
| AJBR difference . | P value . | AJBR difference . | P value . | |
| Treatment product | ||||
| Recombinant SHL | Ref | Ref | ||
| FVIII mimetics | −1.0037 | <.0001 | ||
| Plasma-derived | −0.2084 | .2808 | 0.8864 | .0064 |
| Recombinant EHL | −0.258 | .0037 | −0.0811 | .7122 |
| Missed doses | ||||
| <10% | Ref | Ref | ||
| 10%-20% | 0.6757 | <.0001 | 0.2881 | .1122 |
| 21%-50% | 0.6395 | <.0001 | 1.2397 | <.0001 |
| >50% | 0.638 | .0003 | −0.0503 | .9198 |
| Health insurance | ||||
| Commercial | Ref | Ref | ||
| Government | 0.3983 | .0001 | −0.0763 | .6805 |
| Other | 0.1835 | .2759 | 0.4594 | .1209 |
| Employment status | ||||
| Employed, full or part-time | Ref | Ref | ||
| Not employed, with disability | 0.5204 | .011 | 0.2546 | .5533 |
| Not employed, without disability | 0.2902 | .2057 | 0.9796 | .0386 |
| Educational level | ||||
| Preelementary | Ref | Ref | ||
| Primary/secondary | −0.3904 | .1125 | −0.7259 | .0243 |
| 4-y/advanced college degree | −0.4933 | .01 | 0.0722 | .8264 |
| High school/technical/some college | −0.0778 | .6239 | 0.0895 | .6784 |
| Age, y | ||||
| 2-9 | Ref | Ref | ||
| 10-19 | 0.3548 | .0131 | 0.7533 | .0015 |
| 20-44 | 1.0105 | <.0001 | 1.7186 | <.0001 |
| Region | ||||
| Northeast | Ref | Ref | ||
| Midwest | 0.3377 | .0067 | 0.7266 | .0039 |
| Southeast | 0.3335 | .0113 | 0.5389 | .04 |
| West | 0.4779 | .0049 | 0.6144 | .0441 |
The findings presented in the table are for those factors that were independently associated with AJBR in hemophilia A and B in multivariable models. Race, ethnicity, and BMI were included in the models but are not shown in the table because the associations between these factors and AJBR were not statistically significant.
AJBR difference is the average number of annual bleeds less (negative value) or more (positive value) than the reference group.
FVIII, factor VIII; Ref, reference group.