HSCT characteristics
Time period of HSCT | |
<2010 | 5 (12.2) |
≥2010 | 36 (87.8) |
Donor type | |
Matched family | 18 (43.9) |
Matched unrelated | 18 (43.9) |
Mismatched related | 4 (9.8) |
Mismatched unrelated | 1 (2.4) |
Stem cell source | |
PBSC | 21 (51.2) |
Marrow | 20 (48.8) |
Conditioning | |
Treosulfan-based (42 g/m2) | 24 (58.5), 14 with thiotepa |
Busulfan-based | 10 (24.4), AUC targeted in 6 |
Melphalan-based | 7 (17.1) |
Serotherapy | |
Alemtuzumab | 22 (53.7) |
ATG | 10 (24.4) |
None | 9 (21.9) |
GVHD prophylaxis | |
CNI + MMF | 16 (39.0) |
CNI + methotrexate | 7 (17.1) |
CNI alone | 7 (17.1) |
PTCy | 7 (17.1) |
None | 4 (9.8) |
Median CD34+ cell dose, ×106/kg | 6.2 (0.05-22.0) |
Time period of HSCT | |
<2010 | 5 (12.2) |
≥2010 | 36 (87.8) |
Donor type | |
Matched family | 18 (43.9) |
Matched unrelated | 18 (43.9) |
Mismatched related | 4 (9.8) |
Mismatched unrelated | 1 (2.4) |
Stem cell source | |
PBSC | 21 (51.2) |
Marrow | 20 (48.8) |
Conditioning | |
Treosulfan-based (42 g/m2) | 24 (58.5), 14 with thiotepa |
Busulfan-based | 10 (24.4), AUC targeted in 6 |
Melphalan-based | 7 (17.1) |
Serotherapy | |
Alemtuzumab | 22 (53.7) |
ATG | 10 (24.4) |
None | 9 (21.9) |
GVHD prophylaxis | |
CNI + MMF | 16 (39.0) |
CNI + methotrexate | 7 (17.1) |
CNI alone | 7 (17.1) |
PTCy | 7 (17.1) |
None | 4 (9.8) |
Median CD34+ cell dose, ×106/kg | 6.2 (0.05-22.0) |
ATG, antithymocyte globulin; CNI, calcineurin inhibitor; MMF, mycophenolate mofetil; PBSC, peripheral blood stem cell; PTCy, posttransplant cyclophosphamide.