Table 1. Replication results in the... | American Society of Hematology

Table 1.

Replication results in the Leucegene-CaG data set for 2 variants previously associated with AML by GWAS

Variant	Risk allele	Gene	All AMLN = 567 cases, 1865 controls		CN-AMLn = 240 cases, 1865 controls		AF of the risk allele
Variant	Risk allele	Gene	P value	OR (95% CI)	P value	OR (95% CI)	gnomAD NFE	Control	Cases all AML	Cases CN-AML
6:32717773 G>A rs3916765	G	HLA-DQA2	.13	1.22 (0.94-1.58)	.003	1.96 (1.26-3.06)	0.89	0.90	0.92	0.95
11:68164294 G>A rs4930561	A	KMT5B	.10	1.13 (0.98-1.30)	.039	1.24 (1.01-1.52)	0.50	0.49	0.52	0.54

Variant	Risk allele	Gene	All AMLN = 567 cases, 1865 controls		CN-AMLn = 240 cases, 1865 controls		AF of the risk allele
Variant	Risk allele	Gene	P value	OR (95% CI)	P value	OR (95% CI)	gnomAD NFE	Control	Cases all AML	Cases CN-AML
6:32717773 G>A rs3916765	G	HLA-DQA2	.13	1.22 (0.94-1.58)	.003	1.96 (1.26-3.06)	0.89	0.90	0.92	0.95
11:68164294 G>A rs4930561	A	KMT5B	.10	1.13 (0.98-1.30)	.039	1.24 (1.01-1.52)	0.50	0.49	0.52	0.54

CI, confidence interval.