Eltrombopag PK adjusted to 50 mg at the highest dose by age group
| . | R/R SAA, n = 11 . | Treatment-naïve SAA, n = 27 . | All patients, N = 38 . | |||
|---|---|---|---|---|---|---|
| 1 to <6 years (n = 1) . | 6 to <18 years (n = 10) . | 1 to <6 years (n = 8) . | 6 to <18 years (n = 19) . | 1 to <6 years (n = 9) . | 6 to <18 years (n = 29) . | |
| AUClast, h∗μg/mL | ||||||
| n | 1 | 7 | 8 | 15 | 9 | 22 |
| Geo-mean (geo-CV%) | 272 | 253 (85.8) | 477 (52.5) | 259 (75.1) | 448 (53.1) | 257 (76.0) |
| AUCtau, h∗μg/mL | ||||||
| n | 1 | 5 | 6 | 10 | 7 | 15 |
| Geo-mean (geo-CV%) | 272 | 306 (63.8) | 502 (65.6) | 275 (52.6) | 460 (64.9) | 285 (54.2) |
| Cmax, μg/mL | ||||||
| n | 1 | 7 | 8 | 15 | 9 | 22 |
| Geo-mean (geo-CV%) | 16.1 | 14.5 (58.2) | 27.1 (40.6) | 15.6 (47.2) | 25.6 (42.2) | 15.2 (49.5) |
| CLss/F, mL/h | ||||||
| n | 1 | 5 | 4 | 9 | 5 | 14 |
| Geo-mean (geo-CV%) | 184 | 164 (63.8) | 96.7 (75.0) | 196 (48.7) | 110 (72.0) | 184 (52.6) |
| . | R/R SAA, n = 11 . | Treatment-naïve SAA, n = 27 . | All patients, N = 38 . | |||
|---|---|---|---|---|---|---|
| 1 to <6 years (n = 1) . | 6 to <18 years (n = 10) . | 1 to <6 years (n = 8) . | 6 to <18 years (n = 19) . | 1 to <6 years (n = 9) . | 6 to <18 years (n = 29) . | |
| AUClast, h∗μg/mL | ||||||
| n | 1 | 7 | 8 | 15 | 9 | 22 |
| Geo-mean (geo-CV%) | 272 | 253 (85.8) | 477 (52.5) | 259 (75.1) | 448 (53.1) | 257 (76.0) |
| AUCtau, h∗μg/mL | ||||||
| n | 1 | 5 | 6 | 10 | 7 | 15 |
| Geo-mean (geo-CV%) | 272 | 306 (63.8) | 502 (65.6) | 275 (52.6) | 460 (64.9) | 285 (54.2) |
| Cmax, μg/mL | ||||||
| n | 1 | 7 | 8 | 15 | 9 | 22 |
| Geo-mean (geo-CV%) | 16.1 | 14.5 (58.2) | 27.1 (40.6) | 15.6 (47.2) | 25.6 (42.2) | 15.2 (49.5) |
| CLss/F, mL/h | ||||||
| n | 1 | 5 | 4 | 9 | 5 | 14 |
| Geo-mean (geo-CV%) | 184 | 164 (63.8) | 96.7 (75.0) | 196 (48.7) | 110 (72.0) | 184 (52.6) |
PK analysis set.
Geo-mean, geometric mean; geo-CV%, geometric coefficient of variation percent.