Immune recovery at days 100 and 180
| . | Whole cohort . | TCD . | PTCy . | CNI . | CNI+ATG . | P value . |
|---|---|---|---|---|---|---|
| Immunerecovery laboratory data at day 100 | ||||||
| ALC, median (range), ×109/L | 0.8 (0.0-7.7) | 0.8 (0.0-4.6) | 0.7 (0.0-3.3) | 0.8 (0.0-7.7) | 0.8 (0.0-7.4) | <.01∗ |
| Missing | 72 (3) | 1 (0) | 10 (3) | 49 (4) | 12 (3) | |
| CD4, ×106/L, median (range) | 158.0 (1.0-1000.0) | 82.0 (1.0-979.0) | 134.5 (4.0-858.0) | 201.0 (1.0-1000.0) | 106.0 (1.0-792.0) | <.01∗ |
| CD8, median (range), ×106/L | 146.0 (1.0-5708.0) | 84.0 (1.0-2402.0) | 127.5 (5.0-2613.0) | 150.0 (1.0-5708.0) | 176.0 (1.0-4270.0) | <.01∗ |
| Missing | 98 (5) | 6 (3) | 20 (7) | 66 (5) | 6 (2) | |
| CD4:CD8 ratio, median (range) | 1.0 (0.0-1000.0) | 0.9 (0.1-35.5) | 0.9 (0.0-26.0) | 1.3 (0.0-93.5) | 0.5 (0.0-21.0) | <.01∗ |
| Missing | 98 (5) | 6 (3) | 20 (7) | 66 (5) | 6 (2) | |
| CD19/CD20, median (range), ×106/L | 64.0 (1.0-2000.0) | 143.0 (1.0-1000.0) | 84.0 (1.0-2000.0) | 62.5 (1.0-2000.0) | 25.0 (1.0-1287.0) | .05∗ |
| Missing | 1466 (70) | 152 (73) | 191 (63) | 849 (71) | 274 (73) | |
| CD56, median (range), ×106/L | 185.0 (3.0-3000.0) | 249.5 (17.0-2912.0) | 165.0 (3.0-2000.0) | 181.0 (5.0-3000.0) | 183.5 (7.0-2000.0) | <.01∗ |
| Missing | 910 (44) | 71 (34) | 122 (40) | 566 (47) | 151 (40) | |
| IgG, median (range), mg/dL | 640.0 (52.0-2800.0) | 668.0 (168.0-1990.0) | 593.0 (74.0-2800.0) | 636.0 (52.0-2343.0) | 684.0 (75.0-1985.0) | <.01∗ |
| Missing | 276 (13) | 18 (9) | 31 (10) | 185 (15) | 42 (11) | |
| IgA, median (range), mg/dL | 59.0 (2.0-630.0) | 49.0 (4.0-630.0) | 58.5 (2.0-357.0) | 59.0 (2.0-457.0) | 73.5 (5.0-561.0) | <.01∗ |
| Missing | 913 (44) | 81 (39) | 118 (39) | 485 (40) | 229 (61) | |
| IgM, median (range), mg/dL | 38.0 (3.0-399.0) | 29.0 (4.0-294.0) | 28.0 (5.0-215.0) | 41.5 (3.0-399.0) | 48.0 (4.0-362.0) | <.01∗ |
| Missing | 909 (44) | 81 (39) | 117 (38) | 481 (40) | 230 (61) | |
| Immune recovery laboratory data at day 180 | ||||||
| ALC, median (range), ×109/L | 1.0 (0.0-9.9) | 1.0 (0.0-9.4) | 1.0 (0.0-7.3) | 1.1 (0.0-9.9) | 0.9 (0.0-6.3) | .04∗ |
| Missing | 82 (4) | 8 (4) | 9 (3) | 49 (4) | 16 (4) | |
| CD4, median (range), ×106/L | 209.0 (1.0-1000.0) | 140.0 (1.0-994.0) | 183.5 (5.0-700.0) | 246.0 (4.0-1000.0) | 143.0 (2.0-7000.0) | <.01∗ |
| CD8, median (range), ×106/L | 230.0 (1.0-8982.0) | 158.0 (3.0-5289.0) | 383.0 (5.0-4548.0) | 216.0 (1.0-8982.0) | 253.0 (1.1-5294.0) | <.01∗ |
| Missing | 84 (4) | 4 (2) | 20 (7) | 54 (4) | 6 (2) | |
| CD4:CD8 ratio, median (range) | 0.8 (0.0-6000.0) | 0.8 (0.0-50.6) | 0.5 (0.0-49.2) | 1.1 (0.0-45.0) | 0.5 (0.0-12.5) | <.01∗ |
| Missing | 84 (4) | 4 (2) | 20 (7) | 54 (4) | 6 (2) | |
| CD19/CD20, median (range), ×10/L | 136.0 (1.0-2000.0) | 242.5 (1.0-1604.0) | 134.0 (2.0-2000.0) | 133.0 (1.0-2000.0) | 98.0 (1.0-2000.0) | <.01∗ |
| Missing | 1384 (66) | 147 (71) | 164 (54) | 812 (67) | 261 (70) | |
| CD56, median (range), ×106/L | 175.0 (2.0-3000.0) | 195.0 (15.0-2356.0) | 158.0 (2.0-2000.0) | 175.0 (3.0-2052.0) | 172.0 (2.0-3000.0) | .11∗ |
| Missing | 896 (43) | 72 (35) | 126 (41) | 550 (46) | 148 (39) | |
| IgG, median (range), mg/dL | 654.0 (49.0-2930.0) | 748.0 (121.0-2339.0) | 649.0 (107.0-2610.0) | 625.0 (49.0-2930.0) | 699.0 (51.0-2432.0) | <.01∗ |
| Missing | 404 (19) | 31 (15) | 73 (24) | 236 (20) | 64 (17) | |
| IgA, median (range), mg/dL | 64.0 (3.0-470.0) | 64.0 (5.0-470.0) | 57.5 (5.0-391.0) | 64.0 (4.0-468.0) | 77.0 (3.0-244.0) | .30∗ |
| Missing | 994 (48) | 86 (42) | 160 (53) | 508 (42) | 240 (64) | |
| IgM, median (range), mg/dL | 59.0 (3.0-397.0) | 81.0 (4.0-383.0) | 45.0 (4.0-311.0) | 59.0 (3.0-386.0) | 61.0 (4.0-397.0) | <.01∗ |
| Missing | 1005 (48) | 88 (43) | 162 (53) | 515 (43) | 240 (64) |
| . | Whole cohort . | TCD . | PTCy . | CNI . | CNI+ATG . | P value . |
|---|---|---|---|---|---|---|
| Immunerecovery laboratory data at day 100 | ||||||
| ALC, median (range), ×109/L | 0.8 (0.0-7.7) | 0.8 (0.0-4.6) | 0.7 (0.0-3.3) | 0.8 (0.0-7.7) | 0.8 (0.0-7.4) | <.01∗ |
| Missing | 72 (3) | 1 (0) | 10 (3) | 49 (4) | 12 (3) | |
| CD4, ×106/L, median (range) | 158.0 (1.0-1000.0) | 82.0 (1.0-979.0) | 134.5 (4.0-858.0) | 201.0 (1.0-1000.0) | 106.0 (1.0-792.0) | <.01∗ |
| CD8, median (range), ×106/L | 146.0 (1.0-5708.0) | 84.0 (1.0-2402.0) | 127.5 (5.0-2613.0) | 150.0 (1.0-5708.0) | 176.0 (1.0-4270.0) | <.01∗ |
| Missing | 98 (5) | 6 (3) | 20 (7) | 66 (5) | 6 (2) | |
| CD4:CD8 ratio, median (range) | 1.0 (0.0-1000.0) | 0.9 (0.1-35.5) | 0.9 (0.0-26.0) | 1.3 (0.0-93.5) | 0.5 (0.0-21.0) | <.01∗ |
| Missing | 98 (5) | 6 (3) | 20 (7) | 66 (5) | 6 (2) | |
| CD19/CD20, median (range), ×106/L | 64.0 (1.0-2000.0) | 143.0 (1.0-1000.0) | 84.0 (1.0-2000.0) | 62.5 (1.0-2000.0) | 25.0 (1.0-1287.0) | .05∗ |
| Missing | 1466 (70) | 152 (73) | 191 (63) | 849 (71) | 274 (73) | |
| CD56, median (range), ×106/L | 185.0 (3.0-3000.0) | 249.5 (17.0-2912.0) | 165.0 (3.0-2000.0) | 181.0 (5.0-3000.0) | 183.5 (7.0-2000.0) | <.01∗ |
| Missing | 910 (44) | 71 (34) | 122 (40) | 566 (47) | 151 (40) | |
| IgG, median (range), mg/dL | 640.0 (52.0-2800.0) | 668.0 (168.0-1990.0) | 593.0 (74.0-2800.0) | 636.0 (52.0-2343.0) | 684.0 (75.0-1985.0) | <.01∗ |
| Missing | 276 (13) | 18 (9) | 31 (10) | 185 (15) | 42 (11) | |
| IgA, median (range), mg/dL | 59.0 (2.0-630.0) | 49.0 (4.0-630.0) | 58.5 (2.0-357.0) | 59.0 (2.0-457.0) | 73.5 (5.0-561.0) | <.01∗ |
| Missing | 913 (44) | 81 (39) | 118 (39) | 485 (40) | 229 (61) | |
| IgM, median (range), mg/dL | 38.0 (3.0-399.0) | 29.0 (4.0-294.0) | 28.0 (5.0-215.0) | 41.5 (3.0-399.0) | 48.0 (4.0-362.0) | <.01∗ |
| Missing | 909 (44) | 81 (39) | 117 (38) | 481 (40) | 230 (61) | |
| Immune recovery laboratory data at day 180 | ||||||
| ALC, median (range), ×109/L | 1.0 (0.0-9.9) | 1.0 (0.0-9.4) | 1.0 (0.0-7.3) | 1.1 (0.0-9.9) | 0.9 (0.0-6.3) | .04∗ |
| Missing | 82 (4) | 8 (4) | 9 (3) | 49 (4) | 16 (4) | |
| CD4, median (range), ×106/L | 209.0 (1.0-1000.0) | 140.0 (1.0-994.0) | 183.5 (5.0-700.0) | 246.0 (4.0-1000.0) | 143.0 (2.0-7000.0) | <.01∗ |
| CD8, median (range), ×106/L | 230.0 (1.0-8982.0) | 158.0 (3.0-5289.0) | 383.0 (5.0-4548.0) | 216.0 (1.0-8982.0) | 253.0 (1.1-5294.0) | <.01∗ |
| Missing | 84 (4) | 4 (2) | 20 (7) | 54 (4) | 6 (2) | |
| CD4:CD8 ratio, median (range) | 0.8 (0.0-6000.0) | 0.8 (0.0-50.6) | 0.5 (0.0-49.2) | 1.1 (0.0-45.0) | 0.5 (0.0-12.5) | <.01∗ |
| Missing | 84 (4) | 4 (2) | 20 (7) | 54 (4) | 6 (2) | |
| CD19/CD20, median (range), ×10/L | 136.0 (1.0-2000.0) | 242.5 (1.0-1604.0) | 134.0 (2.0-2000.0) | 133.0 (1.0-2000.0) | 98.0 (1.0-2000.0) | <.01∗ |
| Missing | 1384 (66) | 147 (71) | 164 (54) | 812 (67) | 261 (70) | |
| CD56, median (range), ×106/L | 175.0 (2.0-3000.0) | 195.0 (15.0-2356.0) | 158.0 (2.0-2000.0) | 175.0 (3.0-2052.0) | 172.0 (2.0-3000.0) | .11∗ |
| Missing | 896 (43) | 72 (35) | 126 (41) | 550 (46) | 148 (39) | |
| IgG, median (range), mg/dL | 654.0 (49.0-2930.0) | 748.0 (121.0-2339.0) | 649.0 (107.0-2610.0) | 625.0 (49.0-2930.0) | 699.0 (51.0-2432.0) | <.01∗ |
| Missing | 404 (19) | 31 (15) | 73 (24) | 236 (20) | 64 (17) | |
| IgA, median (range), mg/dL | 64.0 (3.0-470.0) | 64.0 (5.0-470.0) | 57.5 (5.0-391.0) | 64.0 (4.0-468.0) | 77.0 (3.0-244.0) | .30∗ |
| Missing | 994 (48) | 86 (42) | 160 (53) | 508 (42) | 240 (64) | |
| IgM, median (range), mg/dL | 59.0 (3.0-397.0) | 81.0 (4.0-383.0) | 45.0 (4.0-311.0) | 59.0 (3.0-386.0) | 61.0 (4.0-397.0) | <.01∗ |
| Missing | 1005 (48) | 88 (43) | 162 (53) | 515 (43) | 240 (64) |
Kruskal-Wallis test.