Engraftment, GVHD, and infections
| . | Whole cohort . | TCD . | PTCy . | CNI . | CNI+ATG . | P value . |
|---|---|---|---|---|---|---|
| Characteristic | ||||||
| Time to neutrophil recovery, median (range), d | 16 (0-86) | 11 (1-65) | 17 (1-100) | 17 (1-86) | 13 (0-52) | <.01∗ |
| Time to platelet recovery, median (range), d | 23 (0-98) | 18 (1-88) | 27 (1-95) | 24 (0-98) | 20 (1-98) | <.01∗ |
| Time to aGVHD, median (range), d | 34 (2-100) | 36 (5-180) | 35 (13-187) | 33 (4-210) | 35 (10-208) | .11∗ |
| Infections before day 100 | ||||||
| Bacterial infections, n (%) | .05† | |||||
| No | 1140 (55) | 120 (58) | 183 (60) | 643 (53) | 194 (52) | |
| Yes | 948 (45) | 87 (42) | 120 (39) | 560 (47) | 181 (48) | |
| Missing | 1 (0) | 0 (0) | 1 (0) | 0 (0) | 0 (0) | |
| Time to bacterial infection median (range), d | 11 (1-100) | 8 (1-90) | 11 (1-99) | 11 (1-100) | 12 (1-100) | .08∗ |
| Viral infections, n (%) | .74† | |||||
| No | 1078 (52) | 103 (50) | 157 (52) | 634 (53) | 184 (49) | |
| Yes | 1008 (48) | 104 (50) | 146 (48) | 568 (47) | 190 (51) | |
| Missing | 3 (0) | 0 (0) | 1 (0) | 1 (0) | 1 (0) | |
| Time to viral infection, median (range), d | 28 (1-100) | 27 (1-95) | 31 (1-98) | 27 (1-99) | 28 (1-100) | .35∗ |
| Fungal infections, n (%) | .25† | |||||
| No | 1994 (95) | 199 (96) | 296 (97) | 1145 (95) | 354 (94) | |
| Yes | 91 (4) | 8 (4) | 7 (2) | 57 (5) | 19 (5) | |
| Missing | 4 (0) | 0 (0) | 1 (0) | 1 (0) | 2 (1) | |
| Time to fungal infection, median (range), d | 28 (1-98) | 33 (5-80) | 20 (8-54) | 22 (1-98) | 32 (2-78) | .63∗ |
| Any infection, n (%) | .27† | |||||
| No | 653 (31) | 63 (30) | 111 (37) | 377 (31) | 102 (27) | |
| Yes | 1435 (69) | 144 (70) | 193 (63) | 825 (69) | 273 (73) | |
| Missing | 1 (0) | 0 (0) | 0 (0) | 1 (0) | 0 (0) | |
| Time to any infection, median (range), d | 15 (1-99) | 14 (1-85) | 14 (1-99) | 15 (1-98) | 17 (1-96) | .74∗ |
| Outcomes | ||||||
| Cumulative incidence of grade 2 to 4 aGVHD at 100 days, % (95% CI) | 37.7 (35-40.5) | 27.8 (20.1-36.2) | 28.2 (21.8-35.2) | 44.6 (41-48.4) | 28.8 (22.9-35) | <.001‡ |
| Cumulative incidence of grade 3 to 4 aGVHD at 100 days, % (95% CI) | 10.6 (8.9-12.4) | 8.4 (4.1-14.1) | 6.3 (3.2-10.4) | 12.6 (10.2-15.1) | 8.9 (5.4-13) | .002‡ |
| . | Whole cohort . | TCD . | PTCy . | CNI . | CNI+ATG . | P value . |
|---|---|---|---|---|---|---|
| Characteristic | ||||||
| Time to neutrophil recovery, median (range), d | 16 (0-86) | 11 (1-65) | 17 (1-100) | 17 (1-86) | 13 (0-52) | <.01∗ |
| Time to platelet recovery, median (range), d | 23 (0-98) | 18 (1-88) | 27 (1-95) | 24 (0-98) | 20 (1-98) | <.01∗ |
| Time to aGVHD, median (range), d | 34 (2-100) | 36 (5-180) | 35 (13-187) | 33 (4-210) | 35 (10-208) | .11∗ |
| Infections before day 100 | ||||||
| Bacterial infections, n (%) | .05† | |||||
| No | 1140 (55) | 120 (58) | 183 (60) | 643 (53) | 194 (52) | |
| Yes | 948 (45) | 87 (42) | 120 (39) | 560 (47) | 181 (48) | |
| Missing | 1 (0) | 0 (0) | 1 (0) | 0 (0) | 0 (0) | |
| Time to bacterial infection median (range), d | 11 (1-100) | 8 (1-90) | 11 (1-99) | 11 (1-100) | 12 (1-100) | .08∗ |
| Viral infections, n (%) | .74† | |||||
| No | 1078 (52) | 103 (50) | 157 (52) | 634 (53) | 184 (49) | |
| Yes | 1008 (48) | 104 (50) | 146 (48) | 568 (47) | 190 (51) | |
| Missing | 3 (0) | 0 (0) | 1 (0) | 1 (0) | 1 (0) | |
| Time to viral infection, median (range), d | 28 (1-100) | 27 (1-95) | 31 (1-98) | 27 (1-99) | 28 (1-100) | .35∗ |
| Fungal infections, n (%) | .25† | |||||
| No | 1994 (95) | 199 (96) | 296 (97) | 1145 (95) | 354 (94) | |
| Yes | 91 (4) | 8 (4) | 7 (2) | 57 (5) | 19 (5) | |
| Missing | 4 (0) | 0 (0) | 1 (0) | 1 (0) | 2 (1) | |
| Time to fungal infection, median (range), d | 28 (1-98) | 33 (5-80) | 20 (8-54) | 22 (1-98) | 32 (2-78) | .63∗ |
| Any infection, n (%) | .27† | |||||
| No | 653 (31) | 63 (30) | 111 (37) | 377 (31) | 102 (27) | |
| Yes | 1435 (69) | 144 (70) | 193 (63) | 825 (69) | 273 (73) | |
| Missing | 1 (0) | 0 (0) | 0 (0) | 1 (0) | 0 (0) | |
| Time to any infection, median (range), d | 15 (1-99) | 14 (1-85) | 14 (1-99) | 15 (1-98) | 17 (1-96) | .74∗ |
| Outcomes | ||||||
| Cumulative incidence of grade 2 to 4 aGVHD at 100 days, % (95% CI) | 37.7 (35-40.5) | 27.8 (20.1-36.2) | 28.2 (21.8-35.2) | 44.6 (41-48.4) | 28.8 (22.9-35) | <.001‡ |
| Cumulative incidence of grade 3 to 4 aGVHD at 100 days, % (95% CI) | 10.6 (8.9-12.4) | 8.4 (4.1-14.1) | 6.3 (3.2-10.4) | 12.6 (10.2-15.1) | 8.9 (5.4-13) | .002‡ |