Table 3.

Multivariable analysis by donor group in the PTCy cohort

End pointsMSD vs MUDP (Raw)P (Bonferroni)MSD vs haploP (Raw)P (Bonferroni)MSD vs MMUD
HR/OR (95% CI)
P (Raw)P (Bonferroni)
HR/OR (95% CI)HR/OR (95% CI)
OS  1.20 (1.03-1.41) .019 .096 1.02 (0.88-1.18) .781 1.00 (0.83-1.21) .979 
DFS  1.21 (1.05-1.40) .01 .048 1.04 (0.90-1.19) .61 1.07 (0.90-1.28) .446 
NRM  1.00 (0.77-1.30) .986 0.68 (0.53-0.88) .003 .014 0.74 (0.54-1.01) .055 .164 
Relapse  1.29 (1.08-1.53) .004 .02 1.30 (1.10-1.54) .003 .015 1.26 (1.01-1.56) .038 .153 
Grade 2-4 aGVHD  0.92 (0.73-1.16) .49 0.88 (0.70-1.11) .281 1.02 (0.76-1.35) .917 
Grade 3-4 aGVHD  1.55 (1.06-2.27) .024 .141 1.30 (0.90-1.87) .16 .638 1.46 (0.90-2.37) .123 .615 
Chronic GVHD  1.09 (0.89-1.32) .408 0.92 (0.76-1.11) .375 0.85 (0.68-1.08) .178 .712 
End pointsMSD vs MUDP (Raw)P (Bonferroni)MSD vs haploP (Raw)P (Bonferroni)MSD vs MMUD
HR/OR (95% CI)
P (Raw)P (Bonferroni)
HR/OR (95% CI)HR/OR (95% CI)
OS  1.20 (1.03-1.41) .019 .096 1.02 (0.88-1.18) .781 1.00 (0.83-1.21) .979 
DFS  1.21 (1.05-1.40) .01 .048 1.04 (0.90-1.19) .61 1.07 (0.90-1.28) .446 
NRM  1.00 (0.77-1.30) .986 0.68 (0.53-0.88) .003 .014 0.74 (0.54-1.01) .055 .164 
Relapse  1.29 (1.08-1.53) .004 .02 1.30 (1.10-1.54) .003 .015 1.26 (1.01-1.56) .038 .153 
Grade 2-4 aGVHD  0.92 (0.73-1.16) .49 0.88 (0.70-1.11) .281 1.02 (0.76-1.35) .917 
Grade 3-4 aGVHD  1.55 (1.06-2.27) .024 .141 1.30 (0.90-1.87) .16 .638 1.46 (0.90-2.37) .123 .615 
Chronic GVHD  1.09 (0.89-1.32) .408 0.92 (0.76-1.11) .375 0.85 (0.68-1.08) .178 .712 

aGVHD, acute GVHD; haplo, young, haploidentical donor; MMUD, young, mismatched unrelated donor; MSD, older-aged, matched sibling donor; MUD, young, matched unrelated donor; OR, odds ratio.

Stepdown Bonferroni P value is reported to adjust for multiple comparisons in the PTCy cohort; 95% CI values are not adjusted for multiple comparisons.

HR reported for OS, DFS, NRM, relapse, and chronic GVHD.

OR reported for grade 2 to 4, and grade 3 to 4 acute GVHD.

or Create an Account

Close Modal
Close Modal