Clinical data: microbiome characteristics and IECT outcomes
Disease . | CAR product . | Level . | Bacteria . | Sample size . | Country . | Outcome or association . | Ref . |
---|---|---|---|---|---|---|---|
ALL NHL | 1928z Axi-cel Tisa-cel CTL019 Brexu-cel | Phylum Class Order Family Genera Species | Bacteroidetes Clostridia Bacteroidia Bacteroidiales Rumminococcaceae Bacteroidaceae Bacteroides Ruminococcus Faecalibacterium Akkermansia Faecalibacterium prausnitzii Ruminococcus bromii | 48 | United States | D 100 CR | 90 |
Class Genera Species | Clostridia Ruminococcus Faecalibacterium Faecalibacterium prausnitzii | No toxicity | |||||
NHL | Axi-cel Tisa-cel Liso-cel | Genera | Roseburia Bifidobacterium Lactobacillus Eubacterium | 116 | United States Germany | Non- or “low-risk” antibiotic exposure∗ | 91 |
Species | Bifidobacterium longum Eubacterium eligens Parabacteroides merdae | Alive at 6 mo | |||||
Species | Bacteroides eggerthii Ruminococcus lactaris Eubacterium spp. CAG 180 Akkermansia muciniphila Erysipelatoclostridium ramosum | CR based on deterministic ML model | |||||
Species | Lachnospira pectinoschiza Akkermansia muciniphila | Higher CD3 and CD4 T-cell levels | |||||
MM | BCMA CAR-T | Genera | Bifidobacterium Prevotella Sutterella Oscillospira Paraprevotella Collinsella Faecalibacterium Roseburia Ruminococcus | 43 | China | CR | 93 |
NHL | Not specified | Genera | Faecalibacterium Bifidobacterium Ruminococcus | 12 | |||
ALL NHL | 1928z Axi-cel Tisa-cel CTL019 Brexu-cel | Order Family | Veillonellales Veillonellaceae | 48 | United States | D 100 non-CR | 90 |
NHL | Axi-cel Tisa-cel Liso-cel | Species | Prevotella Veillonella Enterococcus | 116 | United States Germany | “High-risk” antibiotic exposure∗ | 91 |
Species | Bacteroides stercoris | Nonresponse based on deterministic ML model | |||||
Species | Bacteroides uniformis Bacteroides ovatus Blautia spp. Faecalibacterium prausnitzii | Lower CD3 and CD8 T-cell levels | |||||
ALL | Not specified | Genera | Bifidobacterium Roseburia Collinsella | 23 | China | Nonresponse | 93 |
MM | BCMA CAR-T | Genera | Bifidobacterium Leuconostoc | 43 | Severe CRS |
Disease . | CAR product . | Level . | Bacteria . | Sample size . | Country . | Outcome or association . | Ref . |
---|---|---|---|---|---|---|---|
ALL NHL | 1928z Axi-cel Tisa-cel CTL019 Brexu-cel | Phylum Class Order Family Genera Species | Bacteroidetes Clostridia Bacteroidia Bacteroidiales Rumminococcaceae Bacteroidaceae Bacteroides Ruminococcus Faecalibacterium Akkermansia Faecalibacterium prausnitzii Ruminococcus bromii | 48 | United States | D 100 CR | 90 |
Class Genera Species | Clostridia Ruminococcus Faecalibacterium Faecalibacterium prausnitzii | No toxicity | |||||
NHL | Axi-cel Tisa-cel Liso-cel | Genera | Roseburia Bifidobacterium Lactobacillus Eubacterium | 116 | United States Germany | Non- or “low-risk” antibiotic exposure∗ | 91 |
Species | Bifidobacterium longum Eubacterium eligens Parabacteroides merdae | Alive at 6 mo | |||||
Species | Bacteroides eggerthii Ruminococcus lactaris Eubacterium spp. CAG 180 Akkermansia muciniphila Erysipelatoclostridium ramosum | CR based on deterministic ML model | |||||
Species | Lachnospira pectinoschiza Akkermansia muciniphila | Higher CD3 and CD4 T-cell levels | |||||
MM | BCMA CAR-T | Genera | Bifidobacterium Prevotella Sutterella Oscillospira Paraprevotella Collinsella Faecalibacterium Roseburia Ruminococcus | 43 | China | CR | 93 |
NHL | Not specified | Genera | Faecalibacterium Bifidobacterium Ruminococcus | 12 | |||
ALL NHL | 1928z Axi-cel Tisa-cel CTL019 Brexu-cel | Order Family | Veillonellales Veillonellaceae | 48 | United States | D 100 non-CR | 90 |
NHL | Axi-cel Tisa-cel Liso-cel | Species | Prevotella Veillonella Enterococcus | 116 | United States Germany | “High-risk” antibiotic exposure∗ | 91 |
Species | Bacteroides stercoris | Nonresponse based on deterministic ML model | |||||
Species | Bacteroides uniformis Bacteroides ovatus Blautia spp. Faecalibacterium prausnitzii | Lower CD3 and CD8 T-cell levels | |||||
ALL | Not specified | Genera | Bifidobacterium Roseburia Collinsella | 23 | China | Nonresponse | 93 |
MM | BCMA CAR-T | Genera | Bifidobacterium Leuconostoc | 43 | Severe CRS |
ALL, acute lymphoblastic leukemia; axi-cel; axicabtagene ciloleucel; brexu-cel, brexucabtagene autoleucel; liso-cel, lisocabtagene maraleucel; MM, multiple myeloma; tisa-cel, tisagenlecleucel.
“High-risk” antibiotics defined by study as meropenem, cefepime, ceftazidime, and piperacillin-tazobactam. “Low-risk” antibiotic exposure defined by study as exposure to any antibiotic not in the “high-risk” group.91